CCDC63 Activators
CCDC63 can influence the protein's function through various signaling mechanisms. Forskolin, for instance, directly targets adenylate cyclase to increase the production of cAMP, a secondary messenger that is crucial for the activation of protein kinase A (PKA). PKA can phosphorylate various proteins, including CCDC63, which leads to its activation. Similarly, isoproterenol, functioning as a beta-adrenergic agonist, also stimulates adenylate cyclase to elevate cAMP levels, thereby activating PKA. This, in turn, can lead to the phosphorylation and subsequent activation of CCDC63. Another beta-adrenergic agonist, epinephrine, binds to adrenergic receptors and activates the same cAMP/PKA signaling cascade, which has the potential to phosphorylate and activate CCDC63. The direct application of cyclic AMP analogs, such as 3,5-Cyclic AMP and 8-Bromo-cAMP, bypasses receptor-mediated activation and directly activates PKA, which can also result in the phosphorylation and activation of CCDC63.
cAMP-dependent pathways, there are other mechanisms through which chemical activators can influence the activation of CCDC63. Phorbol 12-myristate 13-acetate (PMA) is known to activate protein kinase C (PKC), another kinase that can phosphorylate target proteins, which may include CCDC63, leading to its activation. Ionomycin, by increasing intracellular calcium levels, activates calcium-dependent kinases such as PKC, which could also target CCDC63 for phosphorylation. Anisomycin activates stress-activated protein kinases (SAPKs), which may include CCDC63 in their phosphorylation targets, particularly in response to stress stimuli. The inhibition of protein phosphatases by Okadaic Acid leads to a general increase in phosphorylation levels within the cell, which could result in the activation of CCDC63. Calmodulin, which upon binding to calcium ions, activates various protein kinases that could target CCDC63, potentially leading to its activation. Lastly, Zinc Pyrithione, acting as a zinc ionophore, can modulate cellular signaling pathways that might involve kinases capable of phosphorylating CCDC63, resulting in the protein's activation. These chemical activators, through their diverse effects on cellular signaling molecules and pathways, can orchestrate the functional activation of CCDC63.
SEE ALSO...
Items 1 to 10 of 12 total
Display:
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin activates adenylate cyclase, leading to increased levels of cAMP, a second messenger involved in the regulation of various proteins including CCDC63 by PKA-dependent phosphorylation. | ||||||
(−)-Epinephrine | 51-43-4 | sc-205674 sc-205674A sc-205674B sc-205674C sc-205674D | 1 g 5 g 10 g 100 g 1 kg | $40.00 $102.00 $197.00 $1739.00 $16325.00 | ||
Epinephrine binds to adrenergic receptors, which can trigger a cAMP/PKA signaling cascade, potentially leading to the phosphorylation and activation of CCDC63. | ||||||
Isoproterenol Hydrochloride | 51-30-9 | sc-202188 sc-202188A | 100 mg 500 mg | $27.00 $37.00 | 5 | |
Isoproterenol, a beta-adrenergic agonist, activates adenylate cyclase, increasing cAMP and activating PKA, which in turn could lead to the phosphorylation and functional activation of CCDC63. | ||||||
Adenosine 3′,5′-cyclic monophosphate | 60-92-4 | sc-217584 sc-217584A sc-217584B sc-217584C sc-217584D sc-217584E | 100 mg 250 mg 5 g 10 g 25 g 50 g | $114.00 $175.00 $260.00 $362.00 $617.00 $1127.00 | ||
3,5-cyclic AMP directly activates PKA, which may phosphorylate CCDC63, leading to its functional activation. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
PMA activates protein kinase C (PKC), which can phosphorylate target proteins, potentially including CCDC63, resulting in its activation. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $76.00 $265.00 | 80 | |
Ionomycin increases intracellular calcium levels, which can activate calcium-dependent kinases like PKC, possibly leading to the phosphorylation and activation of CCDC63. | ||||||
8-Bromo-cAMP | 76939-46-3 | sc-201564 sc-201564A | 10 mg 50 mg | $97.00 $224.00 | 30 | |
8-Bromo-cAMP is a cell-permeable cAMP analog that activates PKA, potentially leading to the phosphorylation and subsequent activation of CCDC63. | ||||||
Anisomycin | 22862-76-6 | sc-3524 sc-3524A | 5 mg 50 mg | $97.00 $254.00 | 36 | |
Anisomycin is a protein synthesis inhibitor that can activate stress-activated protein kinases (SAPKs), which might phosphorylate and activate CCDC63 as part of a stress response. | ||||||
Okadaic Acid | 78111-17-8 | sc-3513 sc-3513A sc-3513B | 25 µg 100 µg 1 mg | $285.00 $520.00 $1300.00 | 78 | |
Okadaic Acid is a potent inhibitor of protein phosphatases 1 and 2A, leading to increased phosphorylation levels of cellular proteins, which could include CCDC63, resulting in its activation. | ||||||
Calmodulin (human), (recombinant) | 73298-54-1 | sc-471287 | 1 mg | $232.00 | ||
Calmodulin, when bound to calcium, can activate various protein kinases, which may phosphorylate CCDC63, leading to its functional activation. | ||||||