CCDC40 Activators
CCDC40, a coiled-coil domain-containing protein designated as a molecular ruler complex subunit, stands at the forefront of orchestrating crucial cellular processes associated with motile cilia function. Its fundamental role is indispensable for the proper assembly of inner dynein arms and dynein regulatory complexes, mechanisms that intricately control the coordinated beating of cilia. This intricate regulation is pivotal in determining the correct left-right axis formation, essential for various physiological processes. The significance of CCDC40 is underscored by its direct link to ciliary dyskinesia type 15, a disorder arising from mutations in this gene, leading to defects in cilia motility.
The activation of CCDC40 involves a multifaceted interplay of cellular mechanisms influenced by various chemical modulators. These modulators, whether direct or indirect, play a crucial role in fine-tuning the intricate processes associated with the assembly of inner dynein arms and dynein regulatory complexes. Indirect activators, such as histone deacetylase inhibitors like Trichostatin A, may modulate chromatin structure, potentially influencing transcriptional regulation of CCDC40 and promoting inner dynein arm assembly for improved ciliary motility. Other indirect activators, like AMP-activated protein kinase (AMPK) activators such as A769662, may modulate AMPK signaling pathways, indirectly supporting inner dynein arm assembly and enhancing ciliary motility. These mechanisms collectively showcase the dynamic nature of CCDC40 activation, revealing a finely tuned network of biochemical and cellular pathways that govern its crucial function in maintaining proper cilia motility and left-right axis formation.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $152.00 $479.00 $632.00 $1223.00 $2132.00 | 33 | |
Trichostatin A, a histone deacetylase inhibitor, modulates chromatin structure, potentially influencing transcriptional regulation of CCDC40 and promoting inner dynein arm assembly for improved ciliary motility. | ||||||
SB 431542 | 301836-41-9 | sc-204265 sc-204265A sc-204265B | 1 mg 10 mg 25 mg | $82.00 $216.00 $416.00 | 48 | |
SB431542, a TGF-β receptor inhibitor, indirectly activates CCDC40 by blocking TGF-β signaling. This redirection of signaling pathways may support inner dynein arm assembly, crucial for correct ciliary beat formation. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $67.00 $223.00 $425.00 | 97 | |
Wortmannin enhances CCDC40 function by inhibiting PI3K, potentially influencing signaling pathways that positively regulate the assembly of inner dynein arms, essential for correct ciliary beat coordination. | ||||||
Valproic Acid | 99-66-1 | sc-213144 | 10 g | $87.00 | 9 | |
Valproic Acid, a histone deacetylase inhibitor, may modulate chromatin structure, potentially influencing CCDC40 transcriptional regulation and promoting inner dynein arm assembly for improved ciliary motility. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $90.00 $349.00 | 284 | |
SB203580, a p38 MAPK inhibitor, indirectly activates CCDC40 by influencing cellular pathways that positively regulate inner dynein arm assembly, essential for correct left-right axis formation and ciliary beat control. | ||||||
A-769662 | 844499-71-4 | sc-203790 sc-203790A sc-203790B sc-203790C sc-203790D | 10 mg 50 mg 100 mg 500 mg 1 g | $184.00 $741.00 $1076.00 $3417.00 $5304.00 | 23 | |
A769662, an AMP-activated protein kinase (AMPK) activator, may indirectly enhance CCDC40 function by modulating AMPK signaling pathways, potentially supporting inner dynein arm assembly and ciliary motility. | ||||||
Y-27632, free base | 146986-50-7 | sc-3536 sc-3536A | 5 mg 50 mg | $186.00 $707.00 | 88 | |
Y-27632, a Rho kinase inhibitor, may indirectly activate CCDC40 by influencing cytoskeletal dynamics. This modulation may positively impact the assembly of inner dynein arms, crucial for correct ciliary beat coordination. | ||||||
2-APB | 524-95-8 | sc-201487 sc-201487A | 20 mg 100 mg | $28.00 $53.00 | 37 | |
2-Aminoethoxydiphenyl borate (2-APB) may indirectly enhance CCDC40 function by modulating calcium channels, potentially supporting signaling pathways involved in cilia motility regulation and inner dynein arm assembly. | ||||||
PD173074 | 219580-11-7 | sc-202610 sc-202610A sc-202610B | 1 mg 5 mg 50 mg | $47.00 $143.00 $680.00 | 16 | |
PD173074, a FGFR inhibitor, may indirectly activate CCDC40 by influencing FGFR signaling pathways. This modulation may support inner dynein arm assembly, crucial for correct left-right axis formation and ciliary beat control. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
All-trans retinoic acid (ATRA) may enhance CCDC40 function by activating retinoic acid receptors, potentially influencing transcriptional regulation and promoting inner dynein arm assembly for improved ciliary motility. | ||||||