CCDC169-SOHLH2 Activators
The functional activity of the CCDC169-SOHLH2 fusion protein can be influenced by a range of chemical compounds that target the distinct functionalities of the CCDC169 and SOHLH2 gene products. Retinoic acid, known for its role in gene expression and cell differentiation, might enhance the SOHLH2 component's involvement in developmental processes, aligning with its role in germ cell development. Forskolin and Dibutyryl-cAMP, through their effects on cAMP levels, could potentially modulate the CCDC169 component's function in cellular signaling and processes influenced by cAMP. Compounds like 17-AAG (Tanespimycin), an HSP90 inhibitor, and Trichostatin A, an HDAC inhibitor, may indirectly influence the stability and function of the CCDC169 component of the fusion protein, given CCDC169's coiled-coil domain structure. Curcumin, with its wide-ranging effects on cell signaling, including pathways involved in proliferation and apoptosis, could impact both CCDC169 and SOHLH2 components, influencing various cellular processes.
Genistein and LY294002, affecting tyrosine kinase and PI3K signaling pathways, respectively, might also indirectly impact the SOHLH2 component's function, particularly in pathways related to cell differentiation and development. Rapamycin, an mTOR inhibitor, could play a role in modulating cell growth and proliferation pathways, potentially affecting the functionality of both components of the fusion protein. Additionally, Spermidine and Resveratrol, known for their roles in autophagy, cellular aging, and differentiation processes, might support the SOHLH2 component's involvement in germ cell development within the fusion protein. Epigallocatechin gallate (EGCG), by modulating cell proliferation and apoptosis pathways, could also influence the functional activity of both components of the fusion protein. Together, these compounds illustrate the complexity in modulating the activity of the CCDC169-SOHLH2 fusion protein, reflecting the diverse functional aspects and regulatory mechanisms of its constituent parts.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Retinoic acid influences gene expression and is involved in cell differentiation. Given SOHLH2's role in germ cell development, retinoic acid may indirectly enhance the SOHLH2 component of the CCDC169-SOHLH2 fusion protein in developmental processes. | ||||||
17-AAG | 75747-14-7 | sc-200641 sc-200641A | 1 mg 5 mg | $67.00 $156.00 | 16 | |
17-AAG is an HSP90 inhibitor that can affect protein folding and stability. As CCDC169 is a coiled-coil domain-containing protein, 17-AAG might indirectly influence the stability and function of the CCDC169 part of the fusion protein. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Curcumin modulates various signaling pathways, including those involved in cell proliferation and apoptosis. This could indirectly affect both CCDC169 and SOHLH2 components of the fusion protein, influencing cellular processes. | ||||||
Dibutyryl-cAMP | 16980-89-5 | sc-201567 sc-201567A sc-201567B sc-201567C | 20 mg 100 mg 500 mg 10 g | $47.00 $136.00 $492.00 $4552.00 | 74 | |
Dibutyryl-cAMP, a cAMP analog, mimics the action of cAMP in cells. This could potentially enhance the function of the CCDC169 component in cAMP-dependent cellular processes that might be influenced by the fusion protein. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $45.00 $164.00 $200.00 $402.00 $575.00 $981.00 $2031.00 | 46 | |
Genistein, a tyrosine kinase inhibitor, can modulate cell signaling pathways. This could indirectly affect the SOHLH2 component of the CCDC169-SOHLH2 fusion, particularly in pathways related to cell differentiation and development. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
LY294002, a PI3K inhibitor, could influence cellular signaling pathways related to cell survival and proliferation, potentially affecting both CCDC169 and SOHLH2 components of the fusion protein. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
Rapamycin inhibits mTOR, which is involved in cell growth and proliferation. This inhibition could indirectly influence the functions of both CCDC169 and SOHLH2 components in the fusion protein, particularly in pathways related to cell growth. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $152.00 $479.00 $632.00 $1223.00 $2132.00 | 33 | |
Trichostatin A is an HDAC inhibitor, affecting gene expression and protein acetylation. This could indirectly influence the function of both CCDC169 and SOHLH2 in the fusion protein. | ||||||
Spermidine | 124-20-9 | sc-215900 sc-215900B sc-215900A | 1 g 25 g 5 g | $57.00 $607.00 $176.00 | ||
Spermidine promotes autophagy and may influence cellular aging and differentiation processes, potentially supporting the SOHLH2 component's role in germ cell development within the fusion protein. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol activates SIRT1, influencing gene expression and cellular aging processes. This could indirectly support the SOHLH2 component's role in developmental processes in the CCDC169-SOHLH2 fusion protein. | ||||||