Date published: 2025-12-10

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CB2 Activators

CB2 Activators are chemicals that either directly enhance the functional activity of CB2, a protein known to be involved in immunomodulatory functions. Most of these compounds are selective CB2 agonists, meaning they bind specifically to CB2 receptors and trigger a series of intracellular signaling events that lead to the activation of CB2. This activation can lead to the initiation of CB2's downstream effects, which are largely associated with immunomodulatory functions. Examples of these compounds include JWH-133, AM1241, HU-308, GW842166X, L-759633, and L-759656. These compounds, by binding to CB2, enhance its functional activity and so enhance the immunomodulatory roles of CB2. Other compounds like BAY 59-3074, UR-144, A-836339, AM1714, JTE-907, and LY2828360 also act by binding to CB2 and triggering intracellular signaling events that enhance the functional activity of CB2. These compounds also lead to heightened immunomodulatoryeffects associated with CB2. The binding of these compounds to CB2 triggers signaling cascades that in turn heighten the functional activity of CB2, thereby enhancing the execution of its immunomodulatory roles. The mechanisms of action by which these CB2 activators function underline the key role of CB2 in immune regulation. The selective nature of these compounds suggests specific and targeted activation of CB2, thus illustrating the critical role of CB2 in modulating immune responses.

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Items 11 to 20 of 25 total

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Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

L-759633

174627-50-0sc-203438
10 mg
$187.00
(0)

L-759633 is a selective CB2 receptor agonist. It can enhance the functional activity of CB2 by binding to the receptor, which triggers a series of signaling events leading to CB2 activation, thus enhancing the immunomodulatory roles of CB2.

Anandamide

94421-68-8sc-396321
sc-396321A
sc-396321B
sc-396321C
5 mg
25 mg
500 mg
1 g
$79.00
$215.00
$3988.00
$7660.00
2
(1)

Anandamide, an endocannabinoid, exhibits a remarkable affinity for CB2 receptors, characterized by its ability to induce allosteric modulation. This compound engages in unique hydrophobic interactions, promoting receptor activation through conformational changes. Its dynamic binding kinetics allow for transient interactions, which can fine-tune signaling cascades. Additionally, Anandamide's lipid solubility enhances its diffusion across cellular membranes, facilitating rapid bioavailability and localized effects.

Mead acid ethanolamide

169232-04-6sc-202704
sc-202704A
1 mg
10 mg
$87.00
$825.00
(0)

Mead acid ethanolamide interacts with CB2 receptors through distinct hydrophobic and electrostatic interactions, promoting receptor activation. Its unique structural features enable it to stabilize receptor conformations, influencing downstream signaling pathways. The compound's lipid nature enhances membrane permeability, allowing for efficient cellular uptake. Furthermore, its reaction kinetics suggest a propensity for rapid dissociation, which may modulate receptor sensitivity and signaling duration.

SER 601

1048038-90-9sc-296379
sc-296379A
10 mg
50 mg
$189.00
$810.00
(0)

SER 601 exhibits a unique affinity for CB2 receptors, characterized by its ability to form transient complexes that facilitate receptor conformational changes. The compound's specific steric arrangement allows for selective binding, enhancing its interaction with lipid bilayers. Its dynamic reaction kinetics indicate a balance between stability and reactivity, potentially influencing the duration of receptor engagement. Additionally, SER 601's hydrophobic characteristics contribute to its solubility in lipid-rich environments, promoting effective cellular interactions.

Arachidonamide (20:4, n-6)

85146-53-8sc-221258
sc-221258A
10 mg
50 mg
$96.00
$370.00
(0)

Arachidonamide demonstrates a distinctive interaction with CB2 receptors, primarily through its ability to modulate receptor signaling pathways. Its structural features enable it to engage in specific hydrogen bonding and hydrophobic interactions, promoting receptor activation. The compound's rapid kinetics suggest a swift onset of action, while its affinity for lipid environments enhances membrane integration. This behavior underscores its role in influencing cellular responses through nuanced receptor dynamics.

AM 1172

251908-92-6sc-202456
sc-202456A
10 mg
50 mg
$200.00
$650.00
1
(0)

AM 1172 exhibits a unique affinity for CB2 receptors, characterized by its selective binding that triggers distinct intracellular signaling cascades. The compound's structural conformation allows for effective steric interactions, facilitating receptor activation. Its lipophilic nature enhances membrane penetration, leading to rapid receptor engagement. Additionally, AM 1172's kinetic profile indicates a notable speed in receptor modulation, contributing to its dynamic influence on cellular mechanisms.

Virodhamine hydrochloride

443129-35-9sc-202853
5 mg
$131.00
(0)

Virodhamine hydrochloride demonstrates a selective interaction with CB2 receptors, engaging in unique allosteric modulation that alters receptor conformation. This compound's hydrophobic characteristics promote efficient integration into lipid bilayers, enhancing its bioavailability. Its reaction kinetics reveal a rapid onset of action, with a propensity for transient binding that influences downstream signaling pathways. The compound's distinct molecular interactions contribute to its nuanced effects on cellular activity.

CB 65

913534-05-1sc-361134
sc-361134A
10 mg
50 mg
$347.00
$969.00
(0)

CB 65 exhibits a remarkable affinity for CB2 receptors, characterized by its ability to induce conformational changes that enhance receptor signaling. Its unique structure facilitates specific hydrogen bonding and hydrophobic interactions, promoting stability within lipid environments. The compound's reaction kinetics are notable for their rapid equilibrium, allowing for swift modulation of receptor activity. Additionally, CB 65's distinct molecular interactions play a crucial role in influencing cellular responses and downstream effects.

MDA 19

1048973-47-2sc-358804
sc-358804A
1 mg
5 mg
$28.00
$122.00
(0)

MDA 19 demonstrates a unique interaction profile with CB2 receptors, marked by its capacity to stabilize receptor conformations through specific electrostatic interactions. This compound exhibits a distinctive binding affinity that alters the receptor's activation dynamics, leading to nuanced signaling pathways. Its kinetic behavior is characterized by a delayed onset of action, allowing for prolonged receptor engagement. Furthermore, MDA 19's lipophilicity enhances its membrane permeability, influencing its bioavailability and interaction with cellular components.

N-Arachidonoyl-L-serine

187224-29-9sc-202718
10 mg
$230.00
1
(0)

N-Arachidonoyl-L-serine exhibits a remarkable ability to modulate CB2 receptor activity through selective allosteric binding, which fine-tunes receptor signaling without direct competition with endogenous ligands. This compound's unique structural features facilitate specific hydrogen bonding and hydrophobic interactions, promoting distinct conformational changes in the receptor. Its dynamic reaction kinetics suggest a rapid association and slower dissociation, enhancing its functional longevity within cellular environments.