Molecular structure of MDA 19, CAS Number: 1048973-47-2
MDA 19 (CAS 1048973-47-2)
Alternate Names:
(2Z)-2-(1-hexyl-1,2-dihydro-2-oxo-3H-indol-3-ylidene)hydrazide benzoic acid
Application:
MDA 19 is a selective human peripheral cannabinoid CB2 receptor agonist
CAS Number:
1048973-47-2
Molecular Weight:
349.4
Molecular Formula:
C21H23N3O2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
MDA 19 is a selective agonist of the human peripheral cannabinoid CB2 receptor, with an EC50 for activation (63.4 nM) that is 14-fold lower than that for CB1 activation (EC50 = 867 nM). Surprisingly, it acts as an inverse agonist at the rat CB2 receptor in cell-based functional assays.
MDA 19 (CAS 1048973-47-2) References
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- Effects of caffeic acid phenethyl ester and alpha-tocopherol on reperfusion injury in rat brain. | Irmak, MK., et al. 2003. Cell Biochem Funct. 21: 283-9. PMID: 12910483
- Design and synthesis of a novel series of N-alkyl isatin acylhydrazone derivatives that act as selective cannabinoid receptor 2 agonists for the treatment of neuropathic pain. | Diaz, P., et al. 2008. J Med Chem. 51: 4932-47. PMID: 18666769
- Pharmacological characterization of a novel cannabinoid ligand, MDA19, for treatment of neuropathic pain. | Xu, JJ., et al. 2010. Anesth Analg. 111: 99-109. PMID: 20522703
- The Central Role of Glia in Pathological Pain and the Potential of Targeting the Cannabinoid 2 Receptor for Pain Relief. | Wilkerson, JL. and Milligan, ED. 2011. ISRN Anesthesiol. 2011: PMID: 22442754
- Alterations in endocannabinoid tone following chemotherapy-induced peripheral neuropathy: effects of endocannabinoid deactivation inhibitors targeting fatty-acid amide hydrolase and monoacylglycerol lipase in comparison to reference analgesics following cisplatin treatment. | Guindon, J., et al. 2013. Pharmacol Res. 67: 94-109. PMID: 23127915
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- Anti-tumoral potential of MDA19 in human osteosarcoma via suppressing PI3K/Akt/mTOR signaling pathway. | Liu, B., et al. 2018. Biosci Rep. 38: PMID: 30442873
- MDA-19 Suppresses Progression of Melanoma Via Inhibiting the PI3K/Akt Pathway. | Dang, N., et al. 2018. Open Med (Wars). 13: 416-424. PMID: 30613786
- MDA19, a novel CB2 agonist, inhibits hepatocellular carcinoma partly through inactivation of AKT signaling pathway. | Rao, M., et al. 2019. Biol Direct. 14: 9. PMID: 31053086
- The inhibition of MARK2 suppresses cisplatin resistance of osteosarcoma stem cells by regulating DNA damage and repair. | Xu, L., et al. 2020. J Bone Oncol. 23: 100290. PMID: 32368441
- Cannabinoid receptor activation potential of the next generation, generic ban evading OXIZID synthetic cannabinoid receptor agonists. | Deventer, MH., et al. 2022. Drug Test Anal. 14: 1565-1575. PMID: 35560866
- The mystery behind the apprehensions of the selective cannabinoid receptor type-2 agonist BZO-HEXOXIZID (MDA-19) as a drug of abuse. | de Araujo, KRG., et al. 2023. Forensic Toxicol. 41: 142-150. PMID: 36652069
Activator of:
CB1, and CB2.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
MDA 19, 1 mg | sc-358804 | 1 mg | $29.00 | |||
MDA 19, 5 mg | sc-358804A | 5 mg | $124.00 |