Molecular structure of N-Arachidonoyl-L-serine, CAS Number: 187224-29-9
N-Arachidonoyl-L-serine (CAS 187224-29-9)
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Alternate Names:
N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-L-serine
Application:
N-Arachidonoyl-L-serine is an endocannabinoid-like compound and CB1/CB2 agonist
CAS Number:
187224-29-9
Purity:
≥98%
Molecular Weight:
391.54
Molecular Formula:
C23H37NO4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Endocannabinoid-like brain constituent with similar biological profile like abnormal cannabidiol. Binds weakly to CB1 and CB2 receptors and TRPV1. Produces endothelium-dependent vasodilation. Increases phosphorylation of Akt and mitogen-activated protein.
N-Arachidonoyl-L-serine (CAS 187224-29-9) References
- N-arachidonoyl L-serine, an endocannabinoid-like brain constituent with vasodilatory properties. | Milman, G., et al. 2006. Proc Natl Acad Sci U S A. 103: 2428-33. PMID: 16467152
- Inhibition of human neutrophil chemotaxis by endogenous cannabinoids and phytocannabinoids: evidence for a site distinct from CB1 and CB2. | McHugh, D., et al. 2008. Mol Pharmacol. 73: 441-50. PMID: 17965195
- Nitric oxide synthase inhibition promotes endothelium-dependent vasodilatation and the antihypertensive effect of L-serine. | Mishra, RC., et al. 2008. Hypertension. 51: 791-6. PMID: 18212272
- N-arachidonoyl L-serine, a putative endocannabinoid, alters the activation of N-type Ca2+ channels in sympathetic neurons. | Guo, J., et al. 2008. J Neurophysiol. 100: 1147-51. PMID: 18234973
- The endogenous brain constituent N-arachidonoyl L-serine is an activator of large conductance Ca2+-activated K+ channels. | Godlewski, G., et al. 2009. J Pharmacol Exp Ther. 328: 351-61. PMID: 18923087
- Receptors for acylethanolamides-GPR55 and GPR119. | Godlewski, G., et al. 2009. Prostaglandins Other Lipid Mediat. 89: 105-11. PMID: 19615459
- N-arachidonoyl-L-serine is neuroprotective after traumatic brain injury by reducing apoptosis. | Cohen-Yeshurun, A., et al. 2011. J Cereb Blood Flow Metab. 31: 1768-77. PMID: 21505478
- Molecular sites for the positive allosteric modulation of glycine receptors by endocannabinoids. | Yévenes, GE. and Zeilhofer, HU. 2011. PLoS One. 6: e23886. PMID: 21901142
- N-arachidonoyl-L-serine (AraS) possesses proneurogenic properties in vitro and in vivo after traumatic brain injury. | Cohen-Yeshurun, A., et al. 2013. J Cereb Blood Flow Metab. 33: 1242-50. PMID: 23695434
- Cross-modulation and molecular interaction at the Cav3.3 protein between the endogenous lipids and the T-type calcium channel antagonist TTA-A2. | Cazade, M., et al. 2014. Mol Pharmacol. 85: 218-25. PMID: 24214826
- Palmitoyl Serine: An Endogenous Neuroprotective Endocannabinoid-Like Entity After Traumatic Brain Injury. | Mann, A., et al. 2015. J Neuroimmune Pharmacol. 10: 356-63. PMID: 25721934
- Effect of N-arachidonoyl-l-serine on human cerebromicrovascular endothelium. | Kino, T., et al. 2016. Biochem Biophys Rep. 8: 254-260. PMID: 28955964
- N-Acyl Amino Acids (Elmiric Acids): Endogenous Signaling Molecules with Therapeutic Potential. | Burstein, SH. 2018. Mol Pharmacol. 93: 228-238. PMID: 29138268
- Combining endocannabinoids with retigabine for enhanced M-channel effect and improved KV7 subtype selectivity. | Larsson, JE., et al. 2020. J Gen Physiol. 152: PMID: 32365171
- Effects of Cannabidiol and Delta-9-Tetrahydrocannabinol on Plasma Endocannabinoid Levels in Healthy Volunteers: A Randomized Double-Blind Four-Arm Crossover Study. | Chester, LA., et al. 2022. Cannabis Cannabinoid Res.. PMID: 36493386
Activator of:
CB1, and CB2.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
N-Arachidonoyl-L-serine, 10 mg | sc-202718 | 10 mg | $230.00 |