Anandamide is an endogenous cannabinoid (CB) ligand that binds to brain and peripheral cannabinoid receptors (CB1: Ki=52nm; CB2: Ki=1930nm) and VR1 (Ki=5.78μM), inhibits the binding of [3H]HU-243 to synaptosomal membranes (Ki=52 nM), and inhibits NF-κB activation through direct binding to IKKβ. Some other reported effects of Anandamide are: production of hypothermia and analgesia in mice, decrease in spontaneous motor activity, activation of the MAP kinase (MAPK/ERK) signalling pathway, induction of apoptosis independently of cannabinoid or vanilloid receptors, and inhibition of human breast cancer cell proliferation and migration of tumor cells and T lymphocytes.
Soluble in DMSO (~30 mg/ml), DMF (~10 mg/ml), anhydrous ethanol (5 mg/ml), PBS, pH 7.2 (~100 mg/ml), and water (<0.1 mg/ml at 25° C).
I need percentage purity of anandamide, 25 mg, catalog no.- sc-396321A
Asked by: Aquib
Thank you for your question. Each lot of this chemical comes with a lot-specific Certificate Of Analysis which typically describes the percent purity as well as the method used to determine the purity. You may request a lot-specific Certificate Of Analysis on our website. Alternatively, please contact your local distributor to inquire about the purity of our most recent lot.
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