Date published: 2025-12-10

1-800-457-3801

SCBT Portrait Logo
Seach Input

CB2 Activators

CB2 Activators are chemicals that either directly enhance the functional activity of CB2, a protein known to be involved in immunomodulatory functions. Most of these compounds are selective CB2 agonists, meaning they bind specifically to CB2 receptors and trigger a series of intracellular signaling events that lead to the activation of CB2. This activation can lead to the initiation of CB2's downstream effects, which are largely associated with immunomodulatory functions. Examples of these compounds include JWH-133, AM1241, HU-308, GW842166X, L-759633, and L-759656. These compounds, by binding to CB2, enhance its functional activity and so enhance the immunomodulatory roles of CB2. Other compounds like BAY 59-3074, UR-144, A-836339, AM1714, JTE-907, and LY2828360 also act by binding to CB2 and triggering intracellular signaling events that enhance the functional activity of CB2. These compounds also lead to heightened immunomodulatoryeffects associated with CB2. The binding of these compounds to CB2 triggers signaling cascades that in turn heighten the functional activity of CB2, thereby enhancing the execution of its immunomodulatory roles. The mechanisms of action by which these CB2 activators function underline the key role of CB2 in immune regulation. The selective nature of these compounds suggests specific and targeted activation of CB2, thus illustrating the critical role of CB2 in modulating immune responses.

SEE ALSO...

Items 21 to 25 of 25 total

Display:

Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

Palmitoyl Ethanolamide-d4

1159908-45-8sc-224199
sc-224199A
100 µg
500 µg
$29.00
$130.00
(0)

Palmitoyl Ethanolamide-d4 is characterized by its unique ability to engage with the CB2 receptor through a distinct mechanism of action. Its deuterated structure enhances stability and alters interaction dynamics, allowing for precise modulation of receptor conformations. This compound exhibits a unique affinity profile, promoting selective receptor activation while minimizing off-target effects. The kinetic behavior indicates a balanced rate of binding and unbinding, contributing to its prolonged presence in biological systems.

JTE 907

282089-49-0sc-203616
sc-203616A
10 mg
50 mg
$283.00
$1100.00
(0)

JTE-907 is a selective CB2 inverse agonist. At lower concentrations, it can act as a partial agonist and enhance the functional activity of CB2 by binding to the receptor and triggering intracellular signaling events, thus enhancing CB2's immunomodulatory effects.

Arachidonoyl 2′-fluoroethylamide

166100-37-4sc-202469
5 mg
$200.00
(0)

Arachidonoyl 2'-fluoroethylamide exhibits a remarkable selectivity for the CB2 receptor, driven by its unique fluorinated ethylamide moiety. This modification enhances lipophilicity, facilitating deeper membrane penetration and altering receptor binding kinetics. The compound's interactions promote specific conformational changes in the receptor, leading to distinct signaling pathways. Its stability in biological environments allows for sustained engagement, influencing downstream effects with precision.

Dihomo-γ-linolenylethanolamide

150314-34-4sc-202137
5 mg
$55.00
(0)

Dihomo-γ-linolenylethanolamide is characterized by its unique structural features that enhance its affinity for the CB2 receptor. The compound's elongated carbon chain facilitates unique hydrophobic interactions, promoting effective receptor engagement. Its ability to modulate receptor conformations leads to selective activation of signaling cascades. Additionally, the compound's stability in lipid environments supports prolonged receptor interaction, influencing cellular responses with specificity and efficiency.

Yangonin

500-62-9sc-205889
sc-205889A
5 mg
10 mg
$268.00
$510.00
1
(0)

Yangonin exhibits a distinctive molecular architecture that allows it to selectively bind to the CB2 receptor, primarily through its aromatic ring system, which enhances π-π stacking interactions. This compound's unique stereochemistry contributes to its ability to induce specific conformational changes in the receptor, activating downstream signaling pathways. Furthermore, Yangonin's lipophilic nature aids in its membrane permeability, facilitating rapid cellular uptake and interaction with lipid rafts, thereby influencing receptor dynamics and cellular signaling.