Molecular structure of L-759633, CAS Number: 174627-50-0
L-759633 (CAS 174627-50-0)
Application:
L-759633 is a high affinity and selective CB2 receptor agonist
CAS Number:
174627-50-0
Molecular Weight:
384.59
Molecular Formula:
C26H40O2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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Description
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SDS & Certificate of Analysis
L-759633 is a high affinity, selective CB2 receptor agonist (Ki values are 6.4 and 1043 nM for CB2 and CB1 receptors respectively). Potently inhibits forskolin-stimulated cAMP production via CB2 receptors expressed in CHO cells (EC50 = 8.1 nM).
L-759633 (CAS 174627-50-0) References
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- 3-(1',1'-Dimethylbutyl)-1-deoxy-delta8-THC and related compounds: synthesis of selective ligands for the CB2 receptor. | Huffman, JW., et al. 1999. Bioorg Med Chem. 7: 2905-14. PMID: 10658595
- Behavioral effects of cannabinoid agents in animals. | Chaperon, F. and Thiébot, MH. 1999. Crit Rev Neurobiol. 13: 243-81. PMID: 10803637
- The search for selective ligands for the CB2 receptor. | Huffman, JW. 2000. Curr Pharm Des. 6: 1323-37. PMID: 10903395
- Triaryl bis-sulfones as a new class of cannabinoid CB2 receptor inhibitors: identification of a lead and initial SAR studies. | Lavey, BJ., et al. 2005. Bioorg Med Chem Lett. 15: 783-6. PMID: 15664857
- Chemical modification of the naphthoyl 3-position of JWH-015: in search of a fluorescent probe to the cannabinoid CB2 receptor. | Yates, AS., et al. 2005. Bioorg Med Chem Lett. 15: 3758-62. PMID: 15993070
- Novel identified receptors on mast cells. | Migalovich-Sheikhet, H., et al. 2012. Front Immunol. 3: 238. PMID: 22876248
- Regulation of brain reward by the endocannabinoid system: a critical review of behavioral studies in animals. | Vlachou, S. and Panagis, G. 2014. Curr Pharm Des. 20: 2072-88. PMID: 23829366
- Mechanisms of human eosinophil migration induced by the combination of IL-5 and the endocannabinoid 2-arachidonoyl-glycerol. | Larose, MC., et al. 2014. J Allergy Clin Immunol. 133: 1480-2, 1482.e1-3. PMID: 24530098
- Cannabinoids as therapeutic agents in cancer: current status and future implications. | Chakravarti, B., et al. 2014. Oncotarget. 5: 5852-72. PMID: 25115386
- Cannabinoid Regulation of Brain Reward Processing with an Emphasis on the Role of CB1 Receptors: A Step Back into the Future. | Panagis, G., et al. 2014. Front Psychiatry. 5: 92. PMID: 25132823
- Metabolomic signature of spermatozoa established during holding time is responsible for differences in boar sperm freezability†. | Torres, MA., et al. 2022. Biol Reprod. 106: 213-226. PMID: 34725678
- Anti-cancer effects of selective cannabinoid agonists in pancreatic and breast cancer cells. | Turgut, NH., et al. 2022. Bratisl Lek Listy. 123: 813-821. PMID: 36254639
Activator of:
CB2.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
L-759633, 10 mg | sc-203438 | 10 mg | $187.00 |