cathepsin 7 Inhibitors
Cathepsin 7 inhibitors are specialized chemical compounds that inhibit the activity of cathepsin 7, a cysteine protease enzyme belonging to the cathepsin family. These enzymes are generally involved in the degradation of proteins within the lysosomes, and cathepsin 7 specifically plays a role in processing various extracellular and intracellular proteins. By inhibiting cathepsin 7, these compounds interfere with the enzyme's ability to hydrolyze peptide bonds in its target proteins, which is a critical step in protein catabolism and turnover. Cathepsin 7 inhibitors are typically designed to bind to the enzyme's active site, where they prevent substrate access and thereby halt its proteolytic function. These inhibitors can act through different mechanisms, such as reversible or irreversible binding, depending on their chemical structure and mode of interaction with the enzyme.
Structurally, cathepsin 7 inhibitors often incorporate functional groups that interact with key residues in the enzyme's active site, particularly the cysteine residue that is central to the enzyme's catalytic mechanism. Inhibitors may be designed to mimic the enzyme's natural substrate, which allows for high specificity and effective inhibition. This binding typically involves non-covalent interactions like hydrogen bonding, van der Waals forces, or electrostatic interactions, but some inhibitors may form covalent bonds, resulting in irreversible inhibition. The design and optimization of cathepsin 7 inhibitors often rely on structural studies of the enzyme, such as X-ray crystallography or molecular modeling, which provide insights into the enzyme's active site conformation and potential binding pockets. By targeting cathepsin 7, these inhibitors serve as important tools in understanding the biological roles of this enzyme in cellular processes like protein degradation, cellular remodeling, and maintaining protein homeostasis within the lysosome.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $152.00 $479.00 $632.00 $1223.00 $2132.00 | 33 | |
Trichostatin A, a histone deacetylase inhibitor, could conceivably downregulate cathepsin 7 expression by increasing histone acetylation, thereby altering the chromatin structure at the cathepsin 7 gene locus and reducing the transcriptional activity of this gene. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
By inhibiting DNA methyltransferase, 5-Azacytidine may decrease methylation of the cathepsin 7 gene promoter, which could lead to a reduction in gene transcription and subsequent expression. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol could decrease the expression of cathepsin 7 by activating sirtuins that deacetylate histones associated with the cathepsin 7 gene promoter, leading to tighter chromatin and reduced transcriptional activity. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Curcumin may downregulate cathepsin 7 expression by inhibiting NF-κB, a transcription factor that, when activated, could otherwise enhance the transcription of genes including proteases like cathepsin 7. | ||||||
D,L-Sulforaphane | 4478-93-7 | sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D | 5 mg 10 mg 25 mg 1 g 10 g 250 mg | $153.00 $292.00 $489.00 $1325.00 $8465.00 $933.00 | 22 | |
DL-Sulforaphane could downregulate cathepsin 7 expression through the activation of Nrf2, a transcription factor that may decrease the expression of certain proteases under oxidative stress conditions. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Retinoic acid could decrease cathepsin 7 expression by binding to retinoic acid receptors that heterodimerize with retinoid X receptors, which may then bind to retinoic acid response elements in the promoter region of the cathepsin 7 gene, leading to transcriptional repression. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
Rapamycin could inhibit cathepsin 7 expression by suppressing mTOR pathway signaling, which is responsible for the transcription of several genes, including those coding for proteases, in response to growth and proliferation signals. | ||||||
Spironolactone | 52-01-7 | sc-204294 | 50 mg | $109.00 | 3 | |
Spironolactone could indirectly decrease cathepsin 7 expression by antagonizing aldosterone, which may reduce the expression of genes involved in extracellular matrix remodeling, a process that often includes proteases like cathepsin 7. | ||||||
Hydroxyurea | 127-07-1 | sc-29061 sc-29061A | 5 g 25 g | $78.00 $260.00 | 18 | |
Hydroxyurea could reduce cathepsin 7 expression by disrupting the synthesis of deoxyribonucleotides, leading to inhibition of DNA replication and repair, and thereby decreasing the transcriptional machinery available for cathepsin 7 gene expression. | ||||||
Disulfiram | 97-77-8 | sc-205654 sc-205654A | 50 g 100 g | $53.00 $89.00 | 7 | |
Disulfiram could inhibit cathepsin 7 expression by irreversibly modifying the activity of DNA-binding proteins and transcription factors that are necessary for the expression of the cathepsin 7 gene. | ||||||