CARP Activators
The protein CARP, or Cardiac Ankyrin Repeat Protein, is a key regulator of muscle development and function, primarily expressed in cardiac and skeletal muscle tissues. CARP is characterized by its ankyrin repeat domains, which mediate protein-protein interactions essential for signal transduction and cellular processes. Functionally, CARP plays crucial roles in myofibrillogenesis, sarcomere organization, and transcriptional regulation of muscle-specific genes. Its involvement in these processes contributes to the maintenance of muscle structure and function, ensuring proper muscle contraction and force generation. Additionally, CARP has been implicated in cardiac hypertrophy and remodeling, suggesting its significance in cardiac physiology and pathology.
Activation of CARP typically involves various signaling pathways and transcriptional regulators that modulate its expression and activity. One common mechanism of activation is through the activation of upstream signaling cascades, such as the MAPK/ERK pathway or the calcineurin-NFAT pathway, which subsequently induce the expression of CARP gene through transcription factors like MEF2 and GATA4. Additionally, mechanical stretch or stress stimuli, often experienced during muscle development or cardiac remodeling, can activate CARP expression through mechanotransduction pathways, including integrin signaling and cytoskeletal remodeling. Furthermore, growth factors and cytokines, such as insulin-like growth factor 1 (IGF-1) and transforming growth factor-beta (TGF-β), have been shown to induce CARP expression and promote its activation in muscle cells. Overall, the activation of CARP is tightly regulated by multiple signaling pathways and stimuli, reflecting its importance in muscle biology and its role in physiological and pathological conditions.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
PMA (Phorbol 12-myristate 13-acetate) is a potent activator of protein kinase C (PKC). Its activation of PKC influences downstream events that directly impact CARP. By activating PKC, PMA modulates cellular processes that contribute to CARP activation within the cell. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin activates adenylate cyclase, leading to increased cAMP levels. Elevated cAMP directly influences CARP by modulating downstream events within the cAMP/PKA signaling pathway. The activation of this pathway promotes CARP activation within the cell. | ||||||
Calyculin A | 101932-71-2 | sc-24000 sc-24000A | 10 µg 100 µg | $160.00 $750.00 | 59 | |
Calyculin A is a protein phosphatase inhibitor that activates kinases such as MAPK. Through the activation of MAPK, Calyculin A directly influences CARP. The heightened MAPK activity alters the downstream events that contribute to CARP activation within the cell. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Resveratrol activates SIRT1, a NAD-dependent deacetylase. SIRT1 activation directly influences CARP by modulating cellular processes regulated by SIRT1. The activation of SIRT1 promotes CARP activation within the cell. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $54.00 $128.00 $199.00 $311.00 | 23 | |
A23187 is a calcium ionophore that increases intracellular calcium levels. Elevated calcium levels directly influence CARP by modulating downstream events within the calcium signaling pathway. The activation of this pathway promotes CARP activation within the cell. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $94.00 $349.00 | 114 | |
Thapsigargin is an inhibitor of sarco/endoplasmic reticulum Ca2+-ATPase (SERCA), leading to increased intracellular calcium levels. Elevated calcium levels directly influence CARP by modulating downstream events within the calcium signaling pathway. The activation of this pathway promotes CARP activation within the cell. | ||||||
A-769662 | 844499-71-4 | sc-203790 sc-203790A sc-203790B sc-203790C sc-203790D | 10 mg 50 mg 100 mg 500 mg 1 g | $180.00 $726.00 $1055.00 $3350.00 $5200.00 | 23 | |
A769662 is an AMP-activated protein kinase (AMPK) activator. Its activation of AMPK directly influences CARP by modulating downstream events within the AMPK signaling pathway. The activation of this pathway promotes CARP activation within the cell. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
5-Azacytidine is a DNA methyltransferase inhibitor. Its inhibition of DNA methyltransferases leads to altered DNA methylation patterns, directly influencing CARP. Changes in DNA methylation status alter the cellular processes that contribute to CARP activation within the cell. | ||||||
FTY720 | 162359-56-0 | sc-202161 sc-202161A sc-202161B | 1 mg 5 mg 25 mg | $32.00 $75.00 $118.00 | 14 | |
FTY720 is a sphingosine-1-phosphate (S1P) receptor modulator. By influencing S1P receptors, FTY720 directly activates CARP. The modulation of S1P receptors alters cellular processes that contribute to CARP activation within the cell. | ||||||
GSK-3 Inhibitor IX | 667463-62-9 | sc-202634 sc-202634A sc-202634B | 1 mg 10 mg 50 mg | $57.00 $184.00 $867.00 | 10 | |
GSK-3 Inhibitor IX (BIO) activates the Wnt pathway. Through activation of Wnt signaling, BIO directly influences CARP. The activated Wnt pathway alters cellular processes that contribute to CARP activation within the cell. | ||||||