Date published: 2025-12-14

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CARP Inhibitors

The protein CARP, also known as Cardiac Ankyrin Repeat Protein, is primarily found in cardiac and skeletal muscle tissues, where it plays essential roles in muscle development, function, and regulation. CARP belongs to the ankyrin repeat domain-containing protein family and contains multiple ankyrin repeats that are involved in protein-protein interactions and signal transduction. Functionally, CARP is implicated in various cellular processes, including myofibrillogenesis, sarcomere organization, and transcriptional regulation of muscle-specific genes. It serves as a modulator of muscle cell growth and differentiation, contributing to the maintenance of muscle structure and function. Additionally, CARP has been associated with cardiac hypertrophy and remodeling in response to pathological stimuli, highlighting its significance in cardiac physiology and pathology. Inhibition of CARP typically involves targeting its protein-protein interactions or modulating its expression levels to disrupt its function. One common mechanism of inhibition is through the use of small molecule inhibitors or RNA interference techniques to interfere with CARP's interaction with its binding partners or transcriptional regulators. By preventing these interactions, the downstream signaling pathways and cellular processes regulated by CARP can be effectively inhibited. Additionally, inhibition of CARP may also be achieved through the modulation of upstream signaling pathways or transcription factors that regulate CARP expression, thereby reducing its abundance or activity within the cell. Overall, inhibition of CARP represents a strategy for mitigating pathological conditions associated with aberrant muscle remodeling and dysfunction, particularly in the context of cardiac diseases and skeletal muscle disorders.

Items 1 to 10 of 11 total

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Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

SB 203580

152121-47-6sc-3533
sc-3533A
1 mg
5 mg
$88.00
$342.00
284
(5)

SB-203580 is a selective inhibitor of p38 MAP kinase. By specifically targeting p38 MAP kinase, it modulates the MAPK signaling pathway, indirectly influencing CARP. The inhibition of p38 MAP kinase disrupts the downstream events that contribute to CARP regulation, providing an indirect means to control CARP activity within the cell.

SP600125

129-56-6sc-200635
sc-200635A
10 mg
50 mg
$40.00
$150.00
257
(3)

SP600125 is a selective inhibitor of c-Jun N-terminal kinase (JNK). Its action on JNK influences the JNK signaling pathway, indirectly affecting CARP. The inhibition of JNK disrupts the cellular processes that regulate CARP expression, providing an indirect means to modulate CARP activity within the cell.

LY 294002

154447-36-6sc-201426
sc-201426A
5 mg
25 mg
$121.00
$392.00
148
(1)

LY294002 is a potent inhibitor of phosphoinositide 3-kinases (PI3Ks). Through its action on PI3K, it affects the PI3K/Akt signaling pathway, indirectly impacting CARP. The modulation of this pathway alters the cellular processes that contribute to CARP regulation, providing an indirect means to control CARP activity within the cell.

PD 98059

167869-21-8sc-3532
sc-3532A
1 mg
5 mg
$39.00
$90.00
212
(2)

PD98059 is a selective inhibitor of MEK1, a kinase in the MAPK/ERK signaling pathway. By inhibiting MEK1, it disrupts the MAPK pathway, indirectly influencing CARP. The inhibition of MEK1 alters the downstream events that contribute to CARP regulation, providing an indirect means to control CARP activity within the cell.

Wortmannin

19545-26-7sc-3505
sc-3505A
sc-3505B
1 mg
5 mg
20 mg
$66.00
$219.00
$417.00
97
(3)

Wortmannin is a phosphoinositide 3-kinase (PI3K) inhibitor. Through inhibition of PI3K, it influences the PI3K/Akt signaling pathway, indirectly impacting CARP. The disruption of this pathway alters the cellular processes that contribute to CARP regulation, providing an indirect means to modulate CARP activity within the cell.

SB 431542

301836-41-9sc-204265
sc-204265A
sc-204265B
1 mg
10 mg
25 mg
$80.00
$212.00
$408.00
48
(1)

SB-431542 is a selective inhibitor of the TGF-β receptor I (ALK5). By inhibiting ALK5, it disrupts the TGF-β signaling pathway, indirectly influencing CARP. The inhibition of ALK5 alters the downstream events that contribute to CARP regulation, providing an indirect means to control CARP activity within the cell.

GSK 650394

890842-28-1sc-361201
sc-361201A
10 mg
50 mg
$183.00
$754.00
8
(1)

GSK650394 is a selective inhibitor of p38α MAP kinase. Through inhibition of p38α MAP kinase, it modulates the MAPK signaling pathway, indirectly affecting CARP. The disruption of this pathway alters the downstream events that contribute to CARP regulation, providing an indirect means to modulate CARP activity within the cell.

BAY 11-7082

19542-67-7sc-200615B
sc-200615
sc-200615A
5 mg
10 mg
50 mg
$61.00
$83.00
$349.00
155
(1)

BAY 11-7082 inhibits the nuclear factor-kappa B (NF-κB) pathway. By targeting NF-κB, it modulates downstream events that indirectly influence CARP. The inhibition of NF-κB disrupts the cellular processes that contribute to CARP regulation, providing an indirect means to control CARP activity within the cell.

BIX02188

1094614-84-2sc-503854
10 mg
$380.00
(0)

BIX02188 is a selective inhibitor of MEK5, a component of the MAPK signaling pathway. By inhibiting MEK5, it disrupts the MAPK pathway, indirectly influencing CARP. The inhibition of MEK5 alters the downstream events that contribute to CARP regulation, providing an indirect means to control CARP activity within the cell.

BI-D1870

501437-28-1sc-397022
sc-397022A
1 mg
5 mg
$90.00
$275.00
12
(1)

BI-D1870 is a selective inhibitor of p90 ribosomal S6 kinase (RSK). By inhibiting RSK, it modulates the MAPK/RSK pathway, indirectly influencing CARP. The disruption of this pathway alters the downstream events that contribute to CARP regulation, providing an indirect means to modulate CARP activity within the cell.