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BI-D1870 is a cell permeable, ATP-competitive inhibitor of the four isoforms of ribosomal S6 kinase (p90 RSK) (IC50's at 100µM ATP: RSK1 = 31nM, RSK2 = 24nM, RSK3 = 18nM, RSK4 = 15nM). It does not significantly inhibit 10 other AGC kinases, and over 40 other protein kinases at 100X concentrations. BI-D1870 acts on the N-terminal AGC kinase domain and completely prevents PMA-induced TSC2 phosphorylation.
See how others have used BI-D1870. Click on the entry to view the PubMed entry .
PMID: # 31152846 Teramoto, K.|Katoh, H.| et al. 2019. Cell. Signal. 62: 109329.
PMID: # 27132626 Hamaoka, Y. et al. 2016. Cell. Signal. 28: 937-45.
PMID: # 24057571 Fujiki, K. et al. 2014. Arch. Toxicol. 88: 403-14.
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