BI-D1870 CAS: 501437-28-1
MF: C19H23F2N5O2
MW: 391.41
A cell permeable, ATP-competitive inhibitor.

BI-D1870 (CAS 501437-28-1)

BI-D1870 | CAS 501437-28-1 is rated 5.0 out of 5 by 1.
  • y_2020, m_2, d_20, h_19
  • bvseo_bulk, prod_bvrr, vn_bulk_3.0.5
  • cp_1, bvpage1
  • co_hasreviews, tv_0, tr_1
  • loc_en_US, sid_397022, prod, sort_[SortEntry(order=SUBMISSION_TIME, direction=DESCENDING)]
  • clientName_scbt
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getAggregateRating, 149ms
  • REVIEWS, PRODUCT
5
1
4
0
3
0
2
0
1
0
Synonym: 2-[(3,5-Difluoro-4-hydroxyphenyl)amino]-7,8-dihydro-5,7-dimethyl-8-(3-methylbutyl)-6(5H)-pteridone
Application: A cell permeable, ATP-competitive inhibitor
CAS Number: 501437-28-1
Purity: ≥98%
Molecular Weight: 391.41
Molecular Formula: C19H23F2N5O2
* Refer to Certificate of Analysis for lot specific data (including water content).
Submit a review for this product and receive 15 CruzCredits

BI-D1870 is a cell permeable, ATP-competitive inhibitor of the four isoforms of ribosomal S6 kinase (p90 RSK) (IC50's at 100µM ATP: RSK1 = 31nM, RSK2 = 24nM, RSK3 = 18nM, RSK4 = 15nM). It does not significantly inhibit 10 other AGC kinases, and over 40 other protein kinases at 100X concentrations. BI-D1870 acts on the N-terminal AGC kinase domain and completely prevents PMA-induced TSC2 phosphorylation.

Physical State :
Solid
Solubility :
Soluble in DMSO (>25 mg/ml).
Storage :
Store at -20° C
IC50 :
Rsk-4: IC50 = 15 nM; Rsk-3: IC50 = 18 nM; Rsk-2: IC50 = 24 nM; Rsk-1 : IC50 = 31 nM
pK Values :
pKa: 7.68 (Predicted), pKb: 4.43 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
25023738
SMILES :
CC1C(=O)N(C2=CN=C(N=C2N1CCC(C)C)NC3=CC(=C(C(=C3)F)O)F)C

Download SDS (MSDS)

Certificate of Analysis

Adobe Acrobat Reader is required to reliably view,
print and comment on PDF documents

BI-D1870  Product Citations

See how others have used BI-D1870. Click on the entry to view the PubMed entry .

Citations 1 to 3 of 3 total

PMID: # 31152846  Teramoto, K.|Katoh, H.| et al. 2019. Cell. Signal. 62: 109329.

PMID: # 27132626  Hamaoka, Y. et al. 2016. Cell. Signal. 28: 937-45.

PMID: # 24057571  Fujiki, K. et al. 2014. Arch. Toxicol. 88: 403-14.

Citations 1 to 3 of 3 total

What is the appearance when dissolved in DMSO?

Asked by: SCchem16
Thank you for your question. This chemical, BI-D1870 (CAS 501437-28-1), can vary in color when dissolved in DMSO due to the lot to lot variation in appearance. Part per million impurities can impart color but will have no bearing on the biological activity of a particular compound.
Answered by: Chemical Support 2
Date published: 2017-04-05
  • y_2020, m_2, d_20, h_19CST
  • bvseo_bulk, prod_bvqa, vn_bulk_3.0.5
  • cp_1, bvpage1
  • co_hasquestionsanswers, tq_1
  • loc_en_US, sid_397022, prod, sort_[SortEntry(order=LAST_APPROVED_ANSWER_SUBMISSION_TIME, direction=DESCENDING)]
  • clientName_scbt
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getContent, 133ms
  • QUESTIONS, PRODUCT
Rated 5 out of 5 by from Takada et al Takada et al. (PubMed ID 26386981) found that the ribosomal S6 kinase inhibitor BI-D1870 attenuated experimental autoimmune encephalomyelitis in mice. -SCBT Publication Review
Date published: 2015-01-18
  • y_2020, m_2, d_20, h_19
  • bvseo_bulk, prod_bvrr, vn_bulk_3.0.5
  • cp_1, bvpage1
  • co_hasreviews, tv_0, tr_1
  • loc_en_US, sid_397022, prod, sort_[SortEntry(order=SUBMISSION_TIME, direction=DESCENDING)]
  • clientName_scbt
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getReviews, 9ms
  • REVIEWS, PRODUCT

Santa Cruz Biotechnology, Inc. is a world leader in the development of products for the biomedical research market. Call us Toll Free at 1-800-457-3801.
Copyright © 2007-2020 Santa Cruz Biotechnology, Inc. All Rights Reserved. "Santa Cruz Biotechnology", and the Santa Cruz Biotechnology, Inc. logo, "Santa Cruz Animal Health", "San Juan Ranch", "Supplement of Champions", the San Juan Ranch logo, "Ultracruz", "Chemcruz", "Immunocruz", "Exactacruz", and "EZ Touch" are registered trademarks of Santa Cruz Biotechnology, Inc.
All trademarks are the property of their respective owners.