Molecular structure of GSK 650394, CAS Number: 890842-28-1
GSK 650394 (CAS 890842-28-1)
See product citations (8)
Alternate Names:
2-Cyclopentyl-4-(5-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl-benzoic acid
Application:
GSK 650394 is an SGK1 inhibitor used in prostate cancer research
CAS Number:
890842-28-1
Molecular Weight:
382.45
Molecular Formula:
C25H22N2O2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
GSK 650394 is a compound of interest in biochemical research due to its role as an inhibitor of SGK1, a serine/threonine kinase involved in cellular stress response pathways. This compound is used in studies investigating the regulation of ion channels and transporters, as SGK1 is known to modulate their activity. GSK 650394 aids researchers in dissecting the signaling cascades that contribute to the maintenance of cellular homeostasis and the adaptive responses to environmental changes. Moreover, the compound is utilized in the exploration of SGK1′s function in cell proliferation and survival, with an emphasis on elucidating the molecular mechanisms underlying these processes.
GSK 650394 (CAS 890842-28-1) References
- Spinal SGK1/GRASP-1/Rab4 is involved in complete Freund's adjuvant-induced inflammatory pain via regulating dorsal horn GluR1-containing AMPA receptor trafficking in rats. | Peng, HY., et al. 2012. Pain. 153: 2380-2392. PMID: 22980744
- Serum- and glucocorticoid-regulated kinase 1 is required for nuclear export of the ribonucleoprotein of influenza A virus. | Alamares-Sapuay, JG., et al. 2013. J Virol. 87: 6020-6. PMID: 23487453
- Spinal serum-inducible and glucocorticoid-inducible kinase 1 mediates neuropathic pain via kalirin and downstream PSD-95-dependent NR2B phosphorylation in rats. | Peng, HY., et al. 2013. J Neurosci. 33: 5227-40. PMID: 23516288
- Use of LC-MS/MS and Bayes' theorem to identify protein kinases that phosphorylate aquaporin-2 at Ser256. | Bradford, D., et al. 2014. Am J Physiol Cell Physiol. 307: C123-39. PMID: 24598363
- Aldosterone Upregulates Transient Receptor Potential Melastatin 7 (TRPM7). | Valinsky, WC., et al. 2016. J Biol Chem. 291: 20163-72. PMID: 27466368
- P38 Kinase, SGK1 and NF-κB Dependent Up-Regulation of Na+/Ca2+ Exchanger Expression and Activity Following TGFß1 Treatment of Megakaryocytes. | Al-Maghout, T., et al. 2017. Cell Physiol Biochem. 42: 2169-2181. PMID: 28813704
- Spinal Serum- and Glucocorticoid-Regulated Kinase 1 (SGK1) Signaling Contributes to Morphine-Induced Analgesic Tolerance in Rats. | Xiao, L., et al. 2019. Neuroscience. 413: 206-218. PMID: 31220544
- Vasopressin-stimulated ORAI1 expression and store-operated Ca2+ entry in aortic smooth muscle cells. | Zhu, X., et al. 2021. J Mol Med (Berl). 99: 373-382. PMID: 33409552
- Identifying SARS-CoV-2 antiviral compounds by screening for small molecule inhibitors of nsp12/7/8 RNA-dependent RNA polymerase. | Bertolin, AP., et al. 2021. Biochem J. 478: 2425-2443. PMID: 34198323
- Requirement of Na+/H+ Exchanger NHE1 for Vasopressin-Induced Osteogenic Signaling and Calcification in Human Aortic Smooth Muscle Cells. | Zhu, X., et al. 2022. Kidney Blood Press Res. 47: 399-409. PMID: 35339998
- GSK 650394 Inhibits Osteoclasts Differentiation and Prevents Bone Loss via Promoting the Activities of Antioxidant Enzymes In Vitro and In Vivo. | Jin, LY., et al. 2022. Oxid Med Cell Longev. 2022: 3458560. PMID: 36164394
- Hepatocyte SGK1 activated by hepatic ischemia-reperfusion promotes the recurrence of liver metastasis via IL-6/STAT3. | Li, X., et al. 2023. J Transl Med. 21: 121. PMID: 36788538
Inhibitor of:
9130008F23Rik, Cypt4, Cypt6, Esp34, Esp36, Etohi1, FOXP3, GATA-3, LOC100039995, LRRC10B, MKS1, OXSR1, SGK, SGK2, TAPT1, TBC1D1, USP18, WNK4, and WWC3.Activator of:
BEAN, LURAP1L, MBNL1, PIPK I α, R-Spondin3, Rad17, and SGK3.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
GSK 650394, 10 mg | sc-361201 | 10 mg | $187.00 | |||
GSK 650394, 50 mg | sc-361201A | 50 mg | $769.00 |