C2CD4D Activators
C2 calcium dependent domain containing 4D (C2CD4D) Activators comprise a class of compounds designed to indirectly enhance the activity of C2CD4D through the modulation of intracellular calcium levels. For instance, calmodulin inhibitors such as W-7 can prevent calmodulin from binding calcium, thereby potentially increasing free calcium within the cell which can activate C2CD4D. Similarly, nifedipine and verapamil block L-type calcium channels, leading to a buildup of intracellular calcium, which in turn can enhance the activation of C2CD4D by providing more calcium ions for its calcium-dependent domain. Ryanodine and caffeine exert their effects by modulating the ryanodine receptor, which controls the release of calcium from the sarcoplasmic reticulum. By stimulating this release, these compounds increase the levels of calcium available for C2CD4D activation. Thapsigargin and cyclopiazonic acid, by inhibiting the SERCA pump, lead to increased cytosolic calcium that can bind to and enhance the activity of C2CD4D.
Bay K 8644, as an L-type calcium channelagonist, directly increases calcium influx, thereby enhancing C2CD4D activity due to the increased availability of calcium ions for binding. SKF-96365, while initially inhibiting receptor-mediated calcium entry, can induce alternative cellular mechanisms to increase calcium levels, which can then activate C2CD4D. The calcium ionophore A23187 directly increases intracellular calcium by transporting ions across the cell membrane, thus enhancing the activity of C2CD4D. Nimodipine, although similar in function to other calcium channel blockers, specifically increases intracellular calcium levels, which in turn can enhance C2CD4D activity by providing calcium ions for its activation.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
W-7 | 61714-27-0 | sc-201501 sc-201501A sc-201501B | 50 mg 100 mg 1 g | $166.00 $306.00 $1675.00 | 18 | |
W-7 binds to calmodulin, inhibiting its interaction with various signaling molecules. Since C2CD4D is calcium-dependent, this inhibition can enhance the availability of calcium, thus indirectly increasing C2CD4D activation due to higher intracellular calcium concentrations. | ||||||
Nifedipine | 21829-25-4 | sc-3589 sc-3589A | 1 g 5 g | $59.00 $173.00 | 15 | |
Nifedipine blocks voltage-dependent L-type calcium channels, which can lead to an accumulation of intracellular calcium. This accumulation can enhance C2CD4D activity, as the protein's function is dependent on calcium levels. | ||||||
Ryanodine | 15662-33-6 | sc-201523 sc-201523A | 1 mg 5 mg | $223.00 $799.00 | 19 | |
Ryanodine binds to and modulates the ryanodine receptor, which can result in increased release of calcium from the sarcoplasmic reticulum. This increase in calcium can enhance the activity of C2CD4D by providing more calcium to bind to its calcium-dependent domain. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $136.00 $446.00 | 114 | |
Thapsigargin inhibits the sarcoplasmic/endoplasmic reticulum Ca2+ ATPase (SERCA) pump, leading to elevated cytosolic calcium levels. This elevation can enhance C2CD4D activity by increasing calcium availability for its calcium-dependent domain. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $55.00 $131.00 $203.00 $317.00 | 23 | |
A23187 is a calcium ionophore that increases intracellular calcium by forming pores in the cell membrane. Elevated intracellular calcium can enhance C2CD4D activity, as it relies on calcium for its function. | ||||||
(±)-Bay K 8644 | 71145-03-4 | sc-203324 sc-203324A sc-203324B | 1 mg 5 mg 50 mg | $84.00 $196.00 $817.00 | ||
Bay K 8644 acts as an L-type calcium channel agonist, increasing calcium influx. This influx can enhance C2CD4D activity due to the increased intracellular calcium that can bind to C2CD4D's calcium-dependent domain. | ||||||
SK&F 96365 | 130495-35-1 | sc-201475 sc-201475B sc-201475A sc-201475C | 5 mg 10 mg 25 mg 50 mg | $103.00 $158.00 $397.00 $656.00 | 2 | |
SKF-96365 inhibits receptor-mediated calcium entry, which can result in compensatory mechanisms that increase intracellular calcium levels. This increase can enhance C2CD4D activity as the protein is calcium-dependent. | ||||||
Cyclopiazonic Acid | 18172-33-3 | sc-201510 sc-201510A | 10 mg 50 mg | $176.00 $624.00 | 3 | |
Cyclopiazonic acid inhibits the SERCA pump, causing an increase in cytosolic calcium levels. The increase in available calcium can enhance C2CD4D activity by binding to its calcium-dependent domain. | ||||||
Caffeine | 58-08-2 | sc-202514 sc-202514A sc-202514B sc-202514C sc-202514D | 50 g 100 g 250 g 1 kg 5 kg | $33.00 $67.00 $97.00 $192.00 $775.00 | 13 | |
Caffeine stimulates the ryanodine receptor, leading to increased calcium release from intracellular stores. This elevated calcium can enhance C2CD4D function by interacting with its calcium-dependent domain. | ||||||
Nimodipine | 66085-59-4 | sc-201464 sc-201464A | 100 mg 1 g | $61.00 $307.00 | 2 | |
Nimodipine is an L-type calcium channel blocker that can lead to increased intracellular calcium levels. The elevated calcium can enhance the activity of C2CD4D through its interaction with the protein's calcium-dependent domain. | ||||||