Nimodipine CAS: 66085-59-4
MF: C21H26N2O7
MW: 418.45
An L-type calcium channel protein inhibitor.

Nimodipine (CAS 66085-59-4)

Nimodipine | CAS 66085-59-4 is rated 5.0 out of 5 by 1.
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Application: Nimodipine is an L-type calcium channel protein inhibitor
CAS Number: 66085-59-4
Purity: ≥98%
Molecular Weight: 418.45
Molecular Formula: C21H26N2O7
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).

Nimodipine is an L-type calcium channel protein inhibitor. Nimodipine is an inhibitor of Mdr.


References

1. Auer, L.M. 1981. Arzneimittelforschung. 3: 1423-1425. PMID: 7197947
2. Dolin, S.J., et al. 1988. Eur. J. Pharmacol. 152: 19-27. PMID: 2463174
3. Triggle, D.J., et al. 1989. Trends Pharmacol. Sci. 10: 507-511. PMID: 2694544
4. Izquierdo, I., et al. 1990. Trends Pharmacol. Sci. 11: 309-310. PMID: 2203191
5. McCarthy, R.T., et al. 1992. J. Neurosci. 12: 2225-2234. PMID: 1318957
6. Fisher, M. and Grotta, J. 1993. Drugs. 46: 961-975. PMID: 7510613
7. Formenti, A., et al. 1993. Neuroreport. 5: 145-147. PMID: 8111001
8. Kappelle, A.C., et al. 1994. Br. J. Pharmacol. 111: 887-893. PMID: 8019766
9. Batuecas, A., et al. 1998. Eur. J. Pharmacol. 350: 141-150. PMID: 9696401

Appearance :
Crystalline
Physical State :
Solid
Solubility :
Soluble in methanol (62.5 mg/ml), DMSO (25 mg/ml), dioxane, water (24.3 mg/L) at 25° C, and ethanol (10 mM). Insoluble in 2-hydroxypropyl-b-cyclodextrin.
Storage :
Store at 4° C
Melting Point :
208.59° C (Predicted)
Boiling Point :
~534.8° C at 760 mmHg (Predicted)
Density :
~1.2 g/cm3 (Predicted)
Refractive Index :
n20D 1.54
IC50 :
LLC-MK2 (Kidney cells): IC50 = 96190 nM (Macaca mulatta); Trypanosoma cruzi: IC50 = 32310 nM; Leishmania major: IC50 = 31040 nM; Leishmania chagasi: IC50 = 21620 nM; Leishmania braziliensis: IC50 = 42800 nM; Cavia porcellus: IC50 = 14.9 nM (Cavia porcellus); Leishmania amazonensis: IC50 = 128.16 µM; Transient receptor potential cation channel subfamily A member 1: EC5050 = 800 nM (Mus musculus)
Ki Data :
Adenosine A3 receptor: Ki= 8470 nM (human); Adenosine A1 recepto: Ki= 20100 nM (Rattus norvegicus); Adenosine A2a receptor: Ki= 44300 nM (Rattus norvegicus)
pK Values :
pKa: 0, pKb: 2.77
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
1
RTECS :
US7975500
PubChem CID :
4497
Merck Index :
14: 6551
MDL Number :
MFCD00153848
EC Number :
266-127-0
Beilstein Registry :
459792
SMILES :
CC1=C(C(C(=C(N1)C)C(=O)OC(C)C)C2=CC(=CC=C2)[N+](=O)[O-])C(=O)OCCOC

Download SDS (MSDS)

Certificate of Analysis

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Rated 5 out of 5 by from Vaseghi G; et al Vaseghi G; et al. (PubMed ID: 26339259) determined that pre-treatment with Nimodipine decreased the corticosterone concentration in both brain and blood, thus preventing memory loss in naloxone-induced morphine withdrawl mice. -SCBT Publication Review
Date published: 2015-05-17
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