C19orf77 Activators
C19orf77 employ various intracellular signaling pathways to modulate the activity of this protein. Forskolin is known to directly stimulate adenylyl cyclase, which catalyzes the conversion of ATP to cAMP, a secondary messenger that activates protein kinase A (PKA). Upon activation, PKA can phosphorylate target proteins, including C19orf77, if it serves as a substrate for this kinase, leading to changes in its activity. Similarly, IBMX functions by inhibiting phosphodiesterases, enzymes that degrade cAMP. By preventing cAMP breakdown, IBMX indirectly sustains the activation of PKA, which may then continue to phosphorylate and affect the activity of C19orf77. Dibutyryl-cAMP, a synthetic analog of cAMP, is capable of diffusing into cells and directly activating PKA, bypassing the need for upstream activators like Forskolin and thus providing a more direct means of promoting C19orf77 activity via phosphorylation.
The activation of C19orf77 can also occur through pathways that do not directly involve cAMP. PMA, for example, activates protein kinase C (PKC), another family of serine/threonine-specific protein kinases. PKC may then phosphorylate C19orf77 if it is among its substrates. Ionomycin increases intracellular calcium levels, which can activate a range of calcium-dependent kinases capable of modifying C19orf77. Epinephrine, which binds to adrenergic receptors, can also elevate intracellular cAMP levels, thus activating PKA and influencing C19orf77 activity. Insulin triggers the PI3K/AKT pathway, where AKT kinase could phosphorylate C19orf77 if it is involved in this signaling cascade. Anisomycin activates stress-activated protein kinases, such as JNK, which may target C19orf77 for phosphorylation. Inhibitors of protein phosphatases like Okadaic Acid and Calyculin A can increase the phosphorylation state of proteins, including C19orf77, by preventing their dephosphorylation. Retinoic Acid affects gene expression and subsequent protein modifications, which may alter kinase or phosphatase activity concerning C19orf77. Lastly, Zinc Pyrithione can modulate signal transduction pathways, which may influence the activation state of C19orf77 through various kinases or by engaging in metalloprotein interactions.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $260.00 $350.00 $500.00 | 34 | |
Isobutylmethylxanthine (IBMX) inhibits phosphodiesterases, preventing the breakdown of cAMP, thus potentially resulting in the activation of C19orf77 through the cAMP/PKA pathway. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
Phorbol 12-myristate 13-acetate (PMA) activates protein kinase C (PKC) which may lead to the phosphorylation and activation of C19orf77 if it is a substrate for PKC. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $78.00 $270.00 | 80 | |
Ionomycin is a calcium ionophore which increases intracellular calcium levels, potentially activating calcium-dependent kinases that may phosphorylate and activate C19orf77. | ||||||
(−)-Epinephrine | 51-43-4 | sc-205674 sc-205674A sc-205674B sc-205674C sc-205674D | 1 g 5 g 10 g 100 g 1 kg | $41.00 $104.00 $201.00 $1774.00 $16500.00 | ||
Epinephrine activates adrenergic receptors which can lead to activation of adenylyl cyclase and subsequent cAMP production, potentially resulting in activation of C19orf77 through the cAMP/PKA pathway. | ||||||
Insulin | 11061-68-0 | sc-29062 sc-29062A sc-29062B | 100 mg 1 g 10 g | $156.00 $1248.00 $12508.00 | 82 | |
Insulin activates the PI3K/AKT signaling pathway, which can lead to the activation of downstream proteins; C19orf77 could be activated as part of this signaling cascade if it is a downstream effector of AKT. | ||||||
Dibutyryl-cAMP | 16980-89-5 | sc-201567 sc-201567A sc-201567B sc-201567C | 20 mg 100 mg 500 mg 10 g | $47.00 $136.00 $492.00 $4552.00 | 74 | |
Dibutyryl-cAMP is a cell-permeable cAMP analog that activates PKA, potentially leading to the phosphorylation and activation of C19orf77 if it is a substrate for PKA. | ||||||
Anisomycin | 22862-76-6 | sc-3524 sc-3524A | 5 mg 50 mg | $99.00 $259.00 | 36 | |
Anisomycin activates stress-activated protein kinases like JNK, which could lead to the activation of C19orf77 through phosphorylation if C19orf77 is part of the JNK signaling pathway. | ||||||
Okadaic Acid | 78111-17-8 | sc-3513 sc-3513A sc-3513B | 25 µg 100 µg 1 mg | $291.00 $530.00 $1800.00 | 78 | |
Okadaic acid is an inhibitor of protein phosphatases 1 and 2A, leading to increased phosphorylation levels of proteins; C19orf77 could be activated due to reduced dephosphorylation. | ||||||
Calyculin A | 101932-71-2 | sc-24000 sc-24000A | 10 µg 100 µg | $163.00 $800.00 | 59 | |
Calyculin A, like okadaic acid, inhibits protein phosphatases, potentially resulting in the activation of C19orf77 through sustained phosphorylation. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Retinoic acid can influence gene expression and subsequent protein modification processes; it might play a role in the post-translational modification that activates C19orf77 through altered kinase or phosphatase activity related to protein turnover. | ||||||