BRCC2 Activators
BRCC2 can engage in diverse mechanisms to enhance its role in the maintenance of genomic stability. Resveratrol, for instance, activates sirtuins such as SIRT1, which are implicated in the longevity and DNA repair pathways. The activation of SIRT1 by resveratrol can lead to the enhancement of DNA repair mechanisms where BRCC2 is a key player. Similarly, Spermidine can initiate autophagy, a cellular recycling process that clears damaged cellular components, thereby facilitating a more efficient DNA repair process that BRCC2 is involved in. AMP-activated protein kinase (AMPK) activators, such as AICAR and metformin, can also play a role in the activation of BRCC2 by triggering AMPK, which then influences various downstream targets involved in DNA repair.
Compounds like Curcumin, Epigallocatechin gallate (EGCG), and Quercetin can modulate different signaling pathways and kinase activities, supporting the role of BRCC2 in DNA damage response. Curcumin, for example, can modulate the activity of proteins associated with DNA repair, which may affect BRCC2 function. EGCG, a catechin found in green tea, influences several signaling pathways, including those related to DNA repair, and can support BRCC2 activity in repairing DNA damage. Sulforaphane, by activating the NRF2 pathway, helps to regulate the expression of antioxidant proteins that guard against oxidative damage, indirectly enhancing BRCC2's function in repairing DNA damage. NAD+ precursors like Nicotinamide mononucleotide (NMN) can increase the levels of NAD+, necessary for sirtuins and PARPs, which are involved in DNA repair, thus potentially enhancing BRCC2 activation. SRT1720, as a specific activator of SIRT1, could lead to activation of DNA repair functions where BRCC2 is involved. Piperlongumine, by increasing intracellular reactive oxygen species, can enhance DNA damage responses that may activate BRCC2's role in the DNA repair pathways. These chemical activators, through various cellular mechanisms, can support the activation of BRCC2, contributing to its role in DNA repair and genomic stability.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol activates sirtuins, particularly SIRT1, which can enhance the repair of damaged DNA. BRCC2's function includes DNA repair, and by activating SIRT1, resveratrol indirectly supports the activation of the DNA repair function that BRCC2 is involved in. | ||||||
Spermidine | 124-20-9 | sc-215900 sc-215900B sc-215900A | 1 g 25 g 5 g | $57.00 $607.00 $176.00 | ||
Spermidine promotes autophagy and has been shown to enhance DNA repair mechanisms. Autophagy can remove damaged cellular components, paving the way for more efficient DNA repair processes in which BRCC2 is actively involved. | ||||||
AICAR | 2627-69-2 | sc-200659 sc-200659A sc-200659B | 50 mg 250 mg 1 g | $65.00 $280.00 $400.00 | 48 | |
AICAR activates AMPK, which in turn can activate downstream targets involved in cellular repair and survival pathways, including those associated with the DNA repair functions of BRCC2. | ||||||
Olaparib | 763113-22-0 | sc-302017 sc-302017A sc-302017B | 250 mg 500 mg 1 g | $210.00 $305.00 $495.00 | 10 | |
Although typically a PARP inhibitor, Olaparib has been shown to induce synthetic lethality in BRCA2-deficient cancers, which indirectly implies its role in DNA repair pathways where BRCC2 is also active. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Curcumin has been reported to enhance DNA repair by modulating the activity of various proteins involved in this pathway, potentially leading to the functional activation of BRCC2 as it participates in the DNA damage response. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
EGCG has been shown to influence several signaling pathways, including those related to DNA repair, and could support the activation of BRCC2's role in the repair of DNA damage. | ||||||
D,L-Sulforaphane | 4478-93-7 | sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D | 5 mg 10 mg 25 mg 1 g 10 g 250 mg | $153.00 $292.00 $489.00 $1325.00 $8465.00 $933.00 | 22 | |
Sulforaphane activates NRF2, a transcription factor that regulates the expression of antioxidant proteins that protect against oxidative damage. This could indirectly enhance the activity of BRCC2 in repairing DNA damage caused by oxidative stress. | ||||||
Metformin | 657-24-9 | sc-507370 | 10 mg | $79.00 | 2 | |
Metformin activates AMPK, which is involved in cellular metabolism and DNA repair mechanisms, potentially leading to the activation of BRCC2 in its role in DNA damage repair. | ||||||
β-Nicotinamide mononucleotide | 1094-61-7 | sc-212376 sc-212376A sc-212376B sc-212376C sc-212376D | 25 mg 100 mg 1 g 2 g 5 g | $110.00 $150.00 $220.00 $300.00 $600.00 | 4 | |
NMN increases the levels of NAD+, which is essential for the activity of sirtuins and PARPs, both involved in DNA repair. Elevated NAD+ levels could therefore enhance the activation of BRCC2 in DNA repair processes. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $110.00 $250.00 $936.00 $50.00 | 33 | |
Quercetin has been observed to modulate kinase activity and protect against DNA damage, which may involve the activation of proteins such as BRCC2 that are crucial for DNA damage response and repair. | ||||||