BRCC2 Inhibitors
BRCC2 inhibitors encompass a diverse array of compounds that can indirectly affect the activity of BRCC2, a protein involved in the crucial cellular process of DNA repair. Bisphenol A, acting as an endocrine disruptor, can bind to estrogen receptors, leading to a cascade of effects that include the dysregulation of signaling pathways critical for maintaining the activity of DNA repair proteins. This can result in the diminished function of BRCC2, as the normal hormonal balance necessary for its optimal activity is disrupted. Triclosan and phthalates, through their ability to interfere with lipid metabolism and hormone activity, can perturb the cellular environment in a way that may decrease the availability of cofactors or alter membrane dynamics critical for BRCC2's role in the DNA damage response.
Heavy metals such as lead, arsenic, cadmium, and mercury represent another class of compounds that can indirectly inhibit BRCC2. These metals can interfere with the enzyme's activity by displacing metal co-factors or binding to critical thiol groups, leading to a loss of structural integrity or an increase in oxidative stress, which can damage proteins and inhibit their functions. For BRCC2, the precise alignment and interaction with other proteins and DNA structures areessential for its role in DNA repair, and heavy metals can disrupt this delicate arrangement. Organic pollutants like PCBs and DDE induce oxidative stress and disrupt hormonal signaling, processes which BRCC2's function is closely associated with. The oxidative stress can lead to protein damage, while the hormonal disruption can result in altered gene expression patterns, both leading to reduced BRCC2 activity.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Bisphenol A | 80-05-7 | sc-391751 sc-391751A | 100 mg 10 g | $300.00 $490.00 | 5 | |
Bisphenol A is an endocrine disruptor that mimics estrogen and can interfere with the estrogen receptor pathway. When the pathway is disrupted, it may lead to alterations in the signaling mechanisms that control the expression and activity of BRCC2, as hormone signaling can be tightly linked with DNA repair processes in which BRCC2 is involved. | ||||||
Triclosan | 3380-34-5 | sc-220326 sc-220326A | 10 g 100 g | $141.00 $408.00 | ||
Triclosan is an antimicrobial agent that can disrupt lipid metabolism and alter cell membrane structure and function. This disruption can affect the localization and function of BRCC2, which may need to interact with lipid rafts for proper DNA repair activity. | ||||||
Bis(2-ethylhexyl) phthalate | 117-81-7 | sc-254975 | 1 g | $57.00 | 2 | |
Phthalates are plasticizers that can interfere with hormone systems, especially those regulating androgen and estrogen. By altering hormone levels, they can indirectly influence the stability and function of proteins like BRCC2 that are involved in DNA repair mechanisms sensitive to hormonal regulation. | ||||||
Lead | 7439-92-1 | sc-250236 | 2 kg | $104.00 | ||
Lead interferes with various enzymes by displacing essential metal ions needed as cofactors. BRCC2, as part of a larger complex involved in DNA repair, may require metal ions for proper structure and function, and lead could diminish its activity by disrupting these metal ion-dependent configurations. | ||||||
Arsenic sponge | 7440-38-2 | sc-278710 | 25 g | $236.00 | ||
Arsenic can bind to proteins at sulfhydryl groups, potentially altering their conformation. For BRCC2, which participates in complex protein interactions for DNA repair, such conformational changes can inhibit its ability to properly engage in those interactions, thereby decreasing its functional activity. | ||||||
Acrylamide Solution, 40% | 79-06-1 | sc-3721 | 1 L | $100.00 | ||
Acrylamide can form adducts with proteins, which can alter their structure and function. If such adducts form on BRCC2 or its interacting partners, this can lead to decreased DNA repair activity of the protein. | ||||||
Atrazine | 1912-24-9 | sc-210846 | 5 g | $165.00 | 1 | |
Atrazine is an herbicide known to disrupt endocrine function, particularly affecting the signaling pathways of estrogen. This disruption can indirectly lead to the inhibition of BRCC2, as the hormone signaling pathways can influence DNA repair processes. | ||||||