BEND7 Activators
BEND7 Activators comprise a range of chemical compounds that indirectly enhance the functional activity of BEND7 through diverse signaling pathways. Forskolin and Isoproterenol, by increasing intracellular cAMP levels, indirectly promote BEND7's function by activating protein kinase A, which may phosphorylate proteins that regulate BEND7's role in chromatin organization and gene expression. Additionally, PMA, as an activator of protein kinase C, might induce phosphorylation events that enhance BEND7's cellular functions, while Ionomycin and A23187, by raising intracellular calcium levels, activate calcium-dependent pathways, potentially leading to the activation of factors that interact with BEND7. The chromatin state is crucial for BEND7's access to DNA, and Trichostatin A, by inhibiting histone deacetylases, may improve BEND7's chromatin interactions, whereas 5-Azacytidine may enhance BEND7's function by inducing gene expression changes through DNA hypomethylation.
The activity of BEND7 is further influenced by compounds that modulate various kinase pathways. LY294002, by inhibiting PI3K, indirectly affects AKT signaling, which could alter the regulation of factors that modulate BEND7's activity. SB431542, a TGF-β receptor blocker, can shift signaling dynamics, potentially favoring BEND7's role in gene expression and differentiation. PD98059 disrupts the MAPK/ERK pathway, which may result in an enhancement of BEND7's gene regulatory functions due to changes in phosphorylation patterns of transcriptional regulators. Furthermore, SNAP, through the release of nitric oxide, activates guanylyl cyclase, increasing cGMP levels and activating PKG, potentially affecting BEND7's signaling-related functions. Epigallocatechin gallate (EGCG) selectively inhibits protein kinases which could lead to a signaling environment that supports BEND7's involvement in DNA repair and apoptosis. Collectively, these activators contribute to the enhancement of BEND7's functional activity by influencing a network of signaling pathways and cellular processes without necessitating direct activation or increased expression of BEND7 itself.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin directly stimulates adenylyl cyclase, increasing intracellular cAMP levels. Elevated cAMP activates PKA, which can phosphorylate a variety of targets that may include transcription factors directly involved in the expression and functional activity of BEND7. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
PMA is a diacylglycerol analog that activates protein kinase C (PKC). PKC activation can lead to phosphorylation events that alter protein-protein interactions and functional activities, potentially enhancing BEND7's role in chromatin organization. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $76.00 $265.00 | 80 | |
Ionomycin is a calcium ionophore that increases intracellular calcium levels, activating calcium-dependent signaling pathways. These pathways may lead to the phosphorylation of regulatory proteins that interact with BEND7, enhancing its cellular function. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
5-Azacytidine inhibits DNA methyltransferases, leading to hypomethylation of DNA. This can result in the upregulation of genes and the subsequent activation of signaling pathways that can indirectly enhance BEND7's function in gene expression regulation. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 is a PI3K inhibitor that can lead to changes in downstream signaling pathways, such as the AKT pathway, potentially affecting the regulation of factors that modulate BEND7's activity in cellular processes. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
Trichostatin A is a histone deacetylase inhibitor which can lead to a more relaxed chromatin state and potentially enhance the accessibility of BEND7 to its chromatin targets. | ||||||
SB 431542 | 301836-41-9 | sc-204265 sc-204265A sc-204265B | 1 mg 10 mg 25 mg | $80.00 $212.00 $408.00 | 48 | |
SB431542 is an inhibitor of the TGF-β receptor, which may shift the balance of cellular signaling pathways, indirectly enhancing BEND7's role in the regulation of gene expression and cellular differentiation. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
PD98059 is an inhibitor of MEK, which is part of the MAPK/ERK pathway. Inhibition of this pathway may alter the phosphorylation status of transcriptional regulators that could enhance the activity of BEND7 in gene regulation. | ||||||
(±)-S-Nitroso-N-acetylpenicillamine | 79032-48-7 | sc-200319B sc-200319 sc-200319A | 10 mg 20 mg 100 mg | $73.00 $112.00 $367.00 | 18 | |
SNAP releases nitric oxide (NO) which can activate guanylyl cyclase, leading to increased cGMP and activation of PKG. PKG can phosphorylate various substrates that might affect BEND7's function in cellular signaling. | ||||||
Isoproterenol Hydrochloride | 51-30-9 | sc-202188 sc-202188A | 100 mg 500 mg | $27.00 $37.00 | 5 | |
Isoproterenol is a β-adrenergic agonist that can increase cAMP levels, similarly to Forskolin, thus activating PKA and potentially enhancing BEND7's activity through phosphorylation of associated regulatory proteins. | ||||||