BEND7 Inhibitors
BEND7 inhibitors encompass a diverse array of chemical compounds, primarily functioning through the modulation of chromatin structure and epigenetic marks. Trichostatin A, Vorinostat, SAHA, Mocetinostat, Entinostat, RGFP966, PXD101, CUDC-101, and MS-275 are all histone deacetylase (HDAC) inhibitors which work by increasing the acetylation levels of histones, a modification that leads to the relaxation of chromatin structure. Given BEND7's involvement in chromatin remodeling and gene expression regulation, these HDAC inhibitors may indirectly restrict BEND7's function. The relaxed chromatin is not the preferred substrate for BEND7 activity, which is implicated in gene silencing and chromatin compaction. Furthermore, the proteasome inhibitor MG132 could lead to the accumulation of proteins that interfere with BEND7's regulatory capabilities, while the DNA methyltransferase inhibitor 5-Azacytidine could disrupt BEND7's function by promoting DNA hypomethylation, thus altering chromatin accessibility and gene expression patterns.
Olaparib, a PARP inhibitor, targets DNA repair enzymes, thus potentially altering the context in which BEND7 operates,considering DNA repair and chromatin dynamics are interconnected. The action of these inhibitors paints a picture of a multi-faceted approach to dampening BEND7 activity: by manipulating the acetylation status of histones and the integrity of DNA repair pathways, the cellular environment becomes less conducive for BEND7 to exert its effects on chromatin. The specificity of these chemicals in targeting the enzymes that regulate epigenetic modifications ensures that the impact on BEND7 is indirect yet significant. The biochemical implications of these inhibitors suggest a concerted disruption of the epigenetic landscape, which would likely attenuate the functional activity of BEND7 as it relies on specific chromatin configurations to execute its role in gene regulation.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
HDAC inhibitor that increases acetylation levels, leading to chromatin relaxation. As BEND7 has been implicated in chromatin remodeling, its function could be indirectly inhibited by preventing the compaction of chromatin necessary for BEND7 to effectively bind DNA and regulate gene expression. | ||||||
Suberoylanilide Hydroxamic Acid | 149647-78-9 | sc-220139 sc-220139A | 100 mg 500 mg | $130.00 $270.00 | 37 | |
Another HDAC inhibitor that functions similarly to Trichostatin A. By promoting hyperacetylation of histones, Vorinostat would hinder BEND7's ability to mediate gene silencing, as open chromatin is less accessible for BEND7's regulatory functions. | ||||||
MG-132 [Z-Leu- Leu-Leu-CHO] | 133407-82-6 | sc-201270 sc-201270A sc-201270B | 5 mg 25 mg 100 mg | $56.00 $260.00 $980.00 | 163 | |
A proteasome inhibitor that prevents the degradation of ubiquitinated proteins. Since BEND7 is associated with gene expression, inhibiting proteasome activity could lead to an accumulation of regulatory proteins that may compete with or inhibit BEND7's function. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
A DNA methyltransferase inhibitor that leads to hypomethylation of DNA. BEND7, being involved in chromatin remodeling, could be affected as DNA methylation is a key epigenetic marker that modulates chromatin structure and gene expression. | ||||||
Olaparib | 763113-22-0 | sc-302017 sc-302017A sc-302017B | 250 mg 500 mg 1 g | $206.00 $299.00 $485.00 | 10 | |
PARP inhibitor that interferes with DNA repair mechanisms. By inhibiting PARP, which is involved in base-excision repair, it could inadvertently affect BEND7's role in chromatin dynamics by altering the DNA repair context in which BEND7 operates. | ||||||
Mocetinostat | 726169-73-9 | sc-364539 sc-364539B sc-364539A | 5 mg 10 mg 50 mg | $210.00 $242.00 $1434.00 | 2 | |
An HDAC inhibitor that can alter gene expression by changing the acetylation status of histones. This alteration can impede BEND7's ability to interact with chromatin and regulate gene expression effectively. | ||||||
MS-275 | 209783-80-2 | sc-279455 sc-279455A sc-279455B | 1 mg 5 mg 25 mg | $24.00 $88.00 $208.00 | 24 | |
An HDAC inhibitor that can modify the acetylation status of histones, potentially impairing BEND7's role in chromatin remodeling and gene expression regulation. | ||||||
RGFP966 | 1357389-11-7 | sc-507300 | 5 mg | $115.00 | ||
An HDAC3-specific inhibitor that by altering histone acetylation could indirectly affect the functions of BEND7 in chromatin remodeling and gene expression. | ||||||
Belinostat | 414864-00-9 | sc-269851 sc-269851A | 10 mg 100 mg | $153.00 $561.00 | ||
An HDAC inhibitor that, through hyperacetylation of histones, could potentially interfere with BEND7's ability to modify chromatin structure and regulate gene expression. | ||||||