Axin Activators
Axin activators belong to a class of molecules that target the Axin protein, a crucial component in the Wnt/β-catenin signaling pathway. The Wnt/β-catenin signaling pathway is an ancient and evolutionarily conserved pathway that plays a critical role in the regulation of cellular processes including cell fate determination, proliferation, migration, and apoptosis. Axin functions as a scaffold protein, assembling a complex of proteins including GSK-3β, APC, and β-catenin. The formation of this complex leads to the phosphorylation and subsequent degradation of β-catenin. In the absence of a Wnt signal, the constant degradation of β-catenin prevents it from translocating to the nucleus and initiating transcription of target genes. Axin, therefore, serves as a negative regulator of the Wnt/β-catenin pathway by facilitating the breakdown of β-catenin.
Axin activators, as the name suggests, amplify the activity of the Axin protein. This increased activity enhances the assembly and stabilization of the Axin-centered protein complex, leading to more efficient β-catenin degradation. Since the level of β-catenin in the cell is tightly regulated, molecules that can activate Axin offer a mechanistic intervention point for modulating the Wnt/β-catenin signaling pathway. The specificity of Axin activators for the Axin protein means that these compounds can fine-tune the pathway's activity without affecting other components. This precision can lead to a more targeted and potentially less disruptive modulation of Wnt/β-catenin signaling compared to interventions that act at other points in the pathway.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
Retinoic acid, a vitamin A derivative, is known to modulate Wnt signaling. It may increase the expression of Axin, thus acting as a negative regulator of the pathway. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Lithium chloride inhibits GSK3β activity. Its use can lead to the stabilization and accumulation of β-catenin. This can feedback to upregulate Axin expression as a balancing mechanism. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $108.00 $245.00 $918.00 $49.00 | 33 | |
Quercetin, a flavonoid, has been demonstrated to influence Wnt signaling components, and it may upregulate Axin expression as part of its modulation of the pathway. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
EGCG, found in green tea, can influence the Wnt signaling pathway. It may enhance Axin expression, contributing to its regulatory effects. | ||||||
Sulindac | 38194-50-2 | sc-202823 sc-202823A sc-202823B | 1 g 5 g 10 g | $31.00 $84.00 $147.00 | 3 | |
Sulindac is a compound (NSAID) that can influence Wnt signaling. It may upregulate Axin expression, adding to its potential pathway modulation. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
Curcumin, a component of turmeric, has been shown to modulate Wnt signaling. It may enhance the expression of Axin, contributing to its potential regulatory effects. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Resveratrol, found in grapes, can influence the Wnt signaling pathway. It may elevate Axin expression, which is part of its mechanism in modulating this pathway. | ||||||
Indirubin | 479-41-4 | sc-201531 sc-201531A | 5 mg 25 mg | $112.00 $515.00 | 4 | |
Indirubin, a component of Chinese traditional medicine, can inhibit GSK3β. It may upregulate Axin expression as part of its effect on the Wnt signaling pathway. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
5-Azacytidine, a DNA methyltransferase inhibitor, may influence the epigenetic regulation of genes. It can potentially elevate Axin expression, affecting the Wnt pathway. | ||||||
Berberine | 2086-83-1 | sc-507337 | 250 mg | $90.00 | 1 | |
Berberine, an isoquinoline alkaloid, has been shown to have effects on the Wnt signaling pathway. It may boost Axin expression as part of its modulation mechanism. | ||||||