ATMIN Activators
ATMIN activators represent a diverse group of chemical compounds that serve to enhance the functional activity of ATMIN, an essential component of the cell's DNA damage response and cell cycle regulation machinery. The TrkB agonist, 7,8-Dihydroxyflavone, activates the PI3K/AKT pathway, a central route in which ATMIN plays a significant role. This activation leads to an upsurge in ATMIN activity, playing a pivotal role in DNA damage response and cell cycle regulation. Resveratrol, a SIRT1 activator, leads to the deacetylation and activation of ATM kinase, thereby enhancing the functional activity of ATMIN.
Other compounds, including Olaparib, Quercetin, and Epigallocatechin gallate (EGCG), also function as ATM kinase activators, leading to an enhancement in ATMIN's functional activity. Doxorubicin and Etoposide induce DNA damage that subsequently activates ATM kinase, which interacts with ATMIN, enhancing its functionality. Interestingly, Caffeine, an ATM kinase inhibitors, also lead to a compensatory upregulation of ATMIN, a testament to the complex feedback mechanisms at play within the cell. Autophagy inhibitor (SIRT1 inhibitor) Nicotinamide also interact with and enhance the functional activity of ATMIN via their effects on DNA damage and ATM kinase activation, respectively.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
7,8-Dihydroxyflavone | 38183-03-8 | sc-278634 | 100 mg | $52.00 | 2 | |
7,8-Dihydroxyflavone, a TrkB agonist, leads to the activation of the PI3K/AKT pathway, which ATMIN is known to be involved in. Activation of this pathway leads to enhanced functional activity of ATMIN in DNA damage response and cell cycle regulation. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol activates SIRT1, which then deacetylates and activates ATM kinase. This kinase directly interacts with ATMIN, leading to enhanced functional activity of ATMIN in DNA damage response and cell cycle regulation. | ||||||
Olaparib | 763113-22-0 | sc-302017 sc-302017A sc-302017B | 250 mg 500 mg 1 g | $210.00 $305.00 $495.00 | 10 | |
Olaparib, a PARP inhibitor, enhances the activity of ATM kinase, which directly interacts with ATMIN. This interaction enhances the functional activity of ATMIN in DNA damage response. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $110.00 $250.00 $936.00 $50.00 | 33 | |
Quercetin activates ATM kinase, which directly interacts with ATMIN. This interaction enhances the functional activity of ATMIN in DNA damage response and cell cycle regulation. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
EGCG, a known activator of ATM kinase, enhances the function of ATMIN. The activation of ATM kinase leads to enhanced functional activity of ATMIN in DNA damage response. | ||||||
Doxorubicin | 23214-92-8 | sc-280681 sc-280681A | 1 mg 5 mg | $176.00 $426.00 | 43 | |
Doxorubicin, an intercalating agent, leads to DNA damage, which stimulates ATM kinase. The activation of ATM kinase increases its interaction with ATMIN, enhancing ATMIN's function in DNA damage response. | ||||||
Etoposide (VP-16) | 33419-42-0 | sc-3512B sc-3512 sc-3512A | 10 mg 100 mg 500 mg | $51.00 $231.00 $523.00 | 63 | |
Etoposide, a topoisomerase II inhibitor, causes DNA damage that activates ATM kinase. This activation enhances the functional activity of ATMIN in DNA damage response. | ||||||
Caffeine | 58-08-2 | sc-202514 sc-202514A sc-202514B sc-202514C sc-202514D | 50 g 100 g 250 g 1 kg 5 kg | $33.00 $67.00 $97.00 $192.00 $775.00 | 13 | |
Caffeine inhibits ATM kinase, resulting in a compensatory upregulation of ATMIN, thereby enhancing its functional activity in DNA damage response. | ||||||
Nicotinamide | 98-92-0 | sc-208096 sc-208096A sc-208096B sc-208096C | 100 g 250 g 1 kg 5 kg | $44.00 $66.00 $204.00 $831.00 | 6 | |
Nicotinamide, a SIRT1 inhibitor, increases acetylation and the subsequent activation of ATM kinase. This activation enhances the functional activity of ATMIN in DNA damage response. | ||||||