ATMIN Inhibitors
Chemical inhibitors of ATMIN can function through various mechanisms to impede the protein's activity within cellular processes, particularly those associated with DNA damage response. KU-60019, CP-466722, and KU-55933 are ATM kinase inhibitors that, by inhibiting ATM kinase, can indirectly inhibit ATMIN. Since ATMIN operates as a cofactor for ATM, these inhibitors compromise ATMIN's recruitment and stabilization, which are critical for its role in orchestrating the cell's response to DNA damage. Chloroquine and 3-Methyladenine disrupt autophagy, with which ATMIN is associated. Chloroquine impairs lysosomal acidification, whereas 3-Methyladenine inhibits class III PI3K, which is necessary for the initiation of autophagy. This interference reduces the participation of ATMIN in autophagic processes, thereby inhibiting its function.
Further indirect inhibition of ATMIN is achieved through compounds affecting upstream elements of the ATM signaling pathway. LY294002 and Wortmannin are PI3K inhibitors that diminish ATM signaling, thus leading to a reduction in ATMIN's activity as a cofactor in this pathway. Mirin targets the Mre11 complex, which collaborates with ATM and ATMIN in DNA repair, and its inhibition hampers ATMIN's role in this complex. NU7441 and VE-821, inhibitors of DNA-PK and ATR respectively, affect the broader DNA damage response in which ATMIN is implicated; by curbing the activities of these kinases, the compounds indirectly impede ATMIN's functional involvement. CGK733, by inhibiting both ATM and ATR kinases, broadly suppresses the DNA damage response network, thereby limiting the functional capacity of ATMIN within these pathways.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
KU 60019 | 925701-46-8 | sc-363284 sc-363284A | 10 mg 50 mg | $248.00 $1035.00 | 1 | |
KU-60019 is an ATM kinase inhibitor which can indirectly inhibit ATMIN, as ATMIN functions as a cofactor for ATM. Inhibition of ATM kinase activity can therefore reduce the functional recruitment of ATMIN to sites of DNA damage. | ||||||
ATM Kinase Inhibitor | 587871-26-9 | sc-202963 | 2 mg | $110.00 | 28 | |
KU-55933 is an inhibitor of the ATM kinase, which may reduce the phosphorylation of ATMIN-dependent substrates, thereby indirectly reducing ATMIN's functional participation in cell cycle checkpoints and DNA repair. | ||||||
Chloroquine | 54-05-7 | sc-507304 | 250 mg | $69.00 | 2 | |
Chloroquine impairs lysosomal function and autophagy, a process with which ATMIN has been associated. Inhibition of autophagy can indirectly reduce ATMIN's role in this cellular pathway. | ||||||
Autophagy Inhibitor, 3-MA | 5142-23-4 | sc-205596 sc-205596A | 50 mg 500 mg | $65.00 $261.00 | 113 | |
3-Methyladenine is an inhibitor of class III PI3K, involved in the initiation of autophagy, and can thereby indirectly reduce ATMIN's involvement in autophagic processes. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
LY294002 inhibits PI3K, which is upstream of ATM kinase signaling. By inhibiting PI3K, this compound can indirectly inhibit ATMIN functions linked to the ATM signaling pathway. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $67.00 $223.00 $425.00 | 97 | |
Wortmannin is a PI3K inhibitor that can affect the ATM signaling pathway. By inhibiting PI3K, this compound can reduce ATMIN activity indirectly, as ATMIN is a cofactor in the ATM signaling pathway. | ||||||
NU 7441 | 503468-95-9 | sc-208107 | 5 mg | $357.00 | 10 | |
NU7441 is a DNA-PK inhibitor and since DNA-PK and ATM are part of the same DNA damage response pathway, inhibition of DNA-PK can lead to a reduction in ATM signaling and consequently ATMIN function. | ||||||
VE 821 | 1232410-49-9 | sc-475878 | 10 mg | $360.00 | ||
VE-821 is an ATR inhibitor, and while ATR is distinct from ATM, both are involved in overlapping DNA damage response pathways. Inhibition of ATR can indirectly inhibit ATMIN by modulating the shared DNA damage response. | ||||||
ATM/ATR Kinase Inhibitor Inhibitor | 905973-89-9 | sc-202964 | 5 mg | $106.00 | 8 | |
CGK733 inhibits ATM and ATR kinases, thereby indirectly inhibiting ATMIN by affecting the overall ATM and ATR kinase-mediated DNA damage response in which ATMIN participates. | ||||||