Aspartoacylase-3 Activators
Aspartoacylase-3 (ACY3) is a protein that is encoded by the ACY3 gene in humans. This protein is predicted to have aminoacylase activity, implying a role in the hydrolysis of acylated amino acids, thus releasing free amino acids and their corresponding acyl groups. While the precise biological function of ACY3 remains a topic of ongoing research, it's known to be located in extracellular exosomes, tiny vesicles that cells use to communicate with each other, suggesting a role in intercellular communication or the transport of substances between cells. The ACY3 protein is expressed in several tissues, with a bias towards the kidney and duodenum, indicating that it might play a more prominent role in these tissues.
The expression of the ACY3 gene, like that of any gene, can be influenced by a variety of factors, including certain chemical compounds. Some compounds have the ability to upregulate or increase the expression of specific genes by interacting with the cell's transcription machinery, the system that cells use to transcribe DNA into RNA, which is then translated into proteins. For instance, chemicals such as retinoic acid, a metabolite of vitamin A, can bind to nuclear receptors and stimulate gene transcription. Similarly, dexamethasone, a glucocorticoid receptor agonist, can bind to glucocorticoid receptors and stimulate the transcription of certain genes. Other compounds, like 5-azacytidine and trichostatin A, can influence gene expression by changing the methylation or acetylation status of DNA and histones, respectively. Yet other compounds, like forskolin, sodium butyrate, and sodium phenylbutyrate, can interact with cellular signaling pathways to stimulate gene transcription. Finally, certain phytochemicals, like curcumin, genistein, resveratrol, sulforaphane, and epigallocatechin gallate (EGCG), can interact with transcription factors to stimulate gene transcription.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Retinoic acid, a metabolite of vitamin A, could potentially bind to nuclear receptors, such as retinoic acid receptors (RARs), leading to the formation of complexes that directly stimulate ACY3 gene transcription. | ||||||
Dexamethasone | 50-02-2 | sc-29059 sc-29059B sc-29059A | 100 mg 1 g 5 g | $91.00 $139.00 $374.00 | 36 | |
Dexamethasone, as a glucocorticoid receptor agonist, may bind to glucocorticoid receptors, causing a conformational change that allows the receptor to translocate into the nucleus and directly stimulate the transcription of the ACY3 gene. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
5-Azacytidine, by inhibiting DNA methyltransferase, can cause hypomethylation of DNA which might potentially lead to the increased transcription of genes, including ACY3. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $152.00 $479.00 $632.00 $1223.00 $2132.00 | 33 | |
Trichostatin A, as a histone deacetylase inhibitor, could potentially increase the acetylation status of histones associated with the ACY3 gene, leading to a more transcriptionally permissive state and increased expression of ACY3. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $31.00 $47.00 $84.00 $222.00 | 19 | |
Sodium Butyrate, as a short-chain fatty acid, could potentially increase the acetylation of histones associated with the ACY3 gene, leading to more transcriptionally active chromatin and thus, increasing ACY3 expression. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin, by activating adenylate cyclase, increases cAMP levels and PKA activity, which could phosphorylate transcription factors that stimulate the transcription of the ACY3 gene. | ||||||
Sodium phenylbutyrate | 1716-12-7 | sc-200652 sc-200652A sc-200652B sc-200652C sc-200652D | 1 g 10 g 100 g 1 kg 10 kg | $77.00 $166.00 $622.00 $5004.00 $32783.00 | 43 | |
Sodium Phenylbutyrate, through its histone deacetylase inhibition activity, could potentially lead to increased acetylation of histones associated with the ACY3 gene, promoting a more transcriptionally active state and upregulating ACY3. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Curcumin could potentially interact with transcription factors, altering their ability to bind to the ACY3 promoter region and thus, stimulating the transcription and subsequent expression of ACY3. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $45.00 $164.00 $200.00 $402.00 $575.00 $981.00 $2031.00 | 46 | |
Genistein, as a phytoestrogen, could potentially bind to estrogen receptors, forming complexes that directly stimulate the transcription of estrogen-responsive genes, possibly including ACY3. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol may interact with various transcription factors, potentially altering their binding to the ACY3 promoter region and stimulating the transcription of the ACY3 gene. | ||||||