Aspartoacylase-3 Antibody (A-5): sc-393862
- Aspartoacylase-3 Antibody (A-5) is a mouse monoclonal IgG2b κ Aspartoacylase-3 antibody provided at 200 µg/ml
- specific for an epitope mapping between amino acids 82-113 within an internal region of Aspartoacylase-3 of human origin
- Aspartoacylase-3 Antibody (A-5) is recommended for detection of Aspartoacylase-3 of mouse, rat and human origin by WB, IP, IF and ELISA
- Anti-Aspartoacylase-3 Antibody (A-5) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP, m-IgG2b BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for Aspartoacylase-3 Antibody (A-5) for WB applications. These reagents are now offered in bundles with Aspartoacylase-3 Antibody (A-5) (see ordering information below).
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Aspartoacylase-3 Antibody (A-5) is a mouse monoclonal IgG2b kappa light chain antibody that detects Aspartoacylase-3 of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Aspartoacylase-3 (A-5) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Aspartoacylase-3, also known as aminoacylase-3, is a 319 amino acid protein primarily expressed in proximal tubules of the kidney, where Aspartoacylase-3 plays a crucial role in deacetylating mercapturic acids, contributing to renal detoxification processes. Aspartoacylase-3 localizes in the cytoplasm of S2 and S3 proximal tubules, and appears in the apical domain of S1 proximal tubules, underscoring Aspartoacylase-3′s importance in renal physiology and potential implications in kidney-related disorders. Aspartoacylase-3 is also expressed at lower levels in stomach, testis, heart, brain, lung, and liver, and may function as a core binding protein for Hepatitis C virus, linking Aspartoacylase-3 to viral pathogenesis. The gene encoding Aspartoacylase-3 is located on human chromosome 11, a region associated with various genetic disorders, including Jervell and Lange-Nielsen syndrome and Niemann-Pick disease, highlighting Aspartoacylase-3′s potential relevance in both health and disease contexts.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
Aspartoacylase-3 Antibody (A-5) References:
- Hereditary angioedema. Long-term follow-up of 88 patients. Experience of the Argentine Allergy and Immunology Institute. | Fabiani, JE., et al. 2000. Allergol Immunopathol (Madr). 28: 267-71. PMID: 11270087
- Smith-Lemli-Opitz syndrome and the DHCR7 gene. | Jira, PE., et al. 2003. Ann Hum Genet. 67: 269-80. PMID: 12914579
- Structural characterization, tissue distribution, and functional expression of murine aminoacylase III. | Pushkin, A., et al. 2004. Am J Physiol Cell Physiol. 286: C848-56. PMID: 14656720
- The pathogenesis and treatment of acid sphingomyelinase-deficient Niemann-Pick disease. | Schuchman, EH. 2007. J Inherit Metab Dis. 30: 654-63. PMID: 17632693
- Chromosomal microarray mapping suggests a role for BSX and Neurogranin in neurocognitive and behavioral defects in the 11q terminal deletion disorder (Jacobsen syndrome). | Coldren, CD., et al. 2009. Neurogenetics. 10: 89-95. PMID: 18855024
- An intronic mutation leading to incomplete skipping of exon-2 in KCNQ1 rescues hearing in Jervell and Lange-Nielsen syndrome. | Bhuiyan, ZA., et al. 2008. Prog Biophys Mol Biol. 98: 319-27. PMID: 19027783
- Identification of a novel protein binding to hepatitis C virus core protein. | Chen, YR., et al. 2009. J Gastroenterol Hepatol. 24: 1300-4. PMID: 19486448
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Aspartoacylase-3 Antibody (A-5) | sc-393862 | 200 µg/ml | $322.00 | |||
Aspartoacylase-3 Antibody (A-5): m-IgG Fc BP-HRP Bundle | sc-530610 | 200 µg Ab; 10 µg BP | $361.00 | |||
Aspartoacylase-3 Antibody (A-5): m-IgGκ BP-HRP Bundle | sc-524124 | 200 µg Ab, 40 µg BP | $361.00 | |||
Aspartoacylase-3 Antibody (A-5): m-IgG2b BP-HRP Bundle | sc-550203 | 200 µg Ab; 10 µg BP | $361.00 | |||
Aspartoacylase-3 Antibody (A-5) AC | sc-393862 AC | 500 µg/ml, 25% agarose | $424.00 | |||
Aspartoacylase-3 Antibody (A-5) HRP | sc-393862 HRP | 200 µg/ml | $322.00 | |||
Aspartoacylase-3 Antibody (A-5) FITC | sc-393862 FITC | 200 µg/ml | $336.00 | |||
Aspartoacylase-3 Antibody (A-5) PE | sc-393862 PE | 200 µg/ml | $349.00 | |||
Aspartoacylase-3 Antibody (A-5) Alexa Fluor® 488 | sc-393862 AF488 | 200 µg/ml | $364.00 | |||
Aspartoacylase-3 Antibody (A-5) Alexa Fluor® 546 | sc-393862 AF546 | 200 µg/ml | $364.00 | |||
Aspartoacylase-3 Antibody (A-5) Alexa Fluor® 594 | sc-393862 AF594 | 200 µg/ml | $364.00 | |||
Aspartoacylase-3 Antibody (A-5) Alexa Fluor® 647 | sc-393862 AF647 | 200 µg/ml | $364.00 | |||
Aspartoacylase-3 Antibody (A-5) Alexa Fluor® 680 | sc-393862 AF680 | 200 µg/ml | $364.00 | |||
Aspartoacylase-3 Antibody (A-5) Alexa Fluor® 790 | sc-393862 AF790 | 200 µg/ml | $364.00 | |||
Aspartoacylase-3 (A-5) Neutralizing Peptide | sc-393862 P | 100 µg/0.5 ml | $69.00 |