ASB-13 Inhibitors
ASB-13 inhibitors refer to a class of chemical compounds that specifically target and inhibit the activity of ASB-13, an adaptor protein that is part of the Ankyrin repeat and SOCS box (ASB) family. These proteins are involved in a variety of intracellular processes, primarily related to the regulation of protein degradation via the ubiquitin-proteasome system. ASB-13 contains ankyrin repeats, which are structural motifs that mediate protein-protein interactions, and a SOCS box, which facilitates the recruitment of ubiquitin ligases. Through this mechanism, ASB-13 helps tag certain proteins for degradation. Inhibitors of ASB-13 disrupt this process, thereby influencing the stability and abundance of proteins regulated by this pathway.
Inhibition of ASB-13 can lead to a modulation of various cellular processes, such as protein turnover, signaling pathways, and cell cycle regulation. These inhibitors are of significant interest in the study of intracellular signaling networks and cellular homeostasis. By preventing ASB-13 from binding to its target proteins or interfering with its ability to recruit ubiquitin ligases, researchers can better understand the role of ASB-13 in cellular regulation. Furthermore, the selective inhibition of ASB-13 can offer valuable insights into the complex interplay between protein degradation pathways and other cellular mechanisms, providing a tool for studying how cells maintain protein quality control and respond to different environmental stimuli.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
This compound could hypothetically decrease ASB-13 expression by demethylating its gene promoter, leading to a loosening of the chromatin structure and an increase in its accessibility to transcriptional repressors. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
Trichostatin A might downregulate ASB-13 expression by inhibiting histone deacetylase activity, resulting in hyperacetylated histones and a subsequent recruitment of transcriptional repressors to the ASB-13 gene locus. | ||||||
Mithramycin A | 18378-89-7 | sc-200909 | 1 mg | $54.00 | 6 | |
By binding to G-C-rich DNA sequences in the promoter of ASB-13, Mithramycin A could obstruct the binding of essential transcriptional activators, thereby reducing its transcriptional initiation and lowering ASB-13 expression. | ||||||
Suberoylanilide Hydroxamic Acid | 149647-78-9 | sc-220139 sc-220139A | 100 mg 500 mg | $130.00 $270.00 | 37 | |
Suberoylanilide Hydroxamic Acid may cause a downregulation of ASB-13 by inhibiting histone deacetylase, which would lead to an increase in the acetylation of histones associated with the ASB-13 gene, potentially allowing binding of repressor proteins. | ||||||
RG 108 | 48208-26-0 | sc-204235 sc-204235A | 10 mg 50 mg | $128.00 $505.00 | 2 | |
RG 108 might reduce ASB-13 expression by inhibiting DNA methyltransferases, thereby decreasing the methylation levels at the ASB-13 gene promoter and allowing the binding of transcriptional repressors. | ||||||
5-Aza-2′-Deoxycytidine | 2353-33-5 | sc-202424 sc-202424A sc-202424B | 25 mg 100 mg 250 mg | $214.00 $316.00 $418.00 | 7 | |
5-Aza-2′-Deoxycytidine could lead to a reduction in ASB-13 expression levels by demethylating CpG islands within the ASB-13 promoter, reducing the affinity for methyl-CpG-binding domain proteins that encourage transcriptional silencing. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
Retinoic acid may decrease the expression of ASB-13 through retinoic acid receptor-mediated repression, which could repress transcription by recruiting co-repressors to the ASB-13 gene promoter. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY 294002 could downregulate ASB-13 expression by inhibiting the phosphoinositide 3-kinases (PI3K) pathway, which might lead to decreased activity of transcription factors that drive ASB-13 gene expression. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
By inhibiting the mammalian target of rapamycin (mTOR) pathway, rapamycin could decrease global protein synthesis rates, including the translation of ASB-13 mRNA into protein, thus reducing ASB-13 levels. | ||||||
D,L-Sulforaphane | 4478-93-7 | sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D | 5 mg 10 mg 25 mg 1 g 10 g 250 mg | $150.00 $286.00 $479.00 $1299.00 $8299.00 $915.00 | 22 | |
DL-Sulforaphane might downregulate ASB-13 expression by activating the transcription factor Nrf2, which could then initiate the transcription of genes involved in cellular defense mechanisms, diverting the cellular machinery away from ASB-13 expression. | ||||||