ANKIB1 Activators
ANKIB1 Activators encompass a spectrum of chemical compounds that bolster ANKIB1's activity through precise cellular signaling cascades. Forskolin, by stimulating adenylate cyclase, bolsters intracellular cAMP, which in turn activates PKA. PKA is known to phosphorylate substrates, potentially including ANKIB1, thereby modulating its interaction with binding partners and enhancing its role within cellular pathways. Similarly, 8-Br-cAMP, a cAMP analog, and Isoproterenol, a β-adrenergic agonist, escalate cAMP levels, subsequently activating PKA which may amplify ANKIB1's functions in cytoskeletal organization and signal transduction. Dibutyryl cAMP operates in an analogous fashion, enhancing PKA activity and possibly ANKIB1's function. Ionomycin and A23187, both calcium ionophores, increase intracellular calcium, which may activate calcium-dependent kinases that can phosphorylate and elevate ANKIB1's activity, affecting processes tied to calcium signaling. Thapsigargin furthers this by upping cytosolic calcium via SERCA pump inhibition, potentially enhancing ANKIB1 activity through calcium-dependent kinase pathways.
The activity of ANKIB1 is further influenced by compounds that modulate various signaling mechanisms. Insulin, through PI3K/Akt pathway activation, and Epidermal Growth Factor (EGF), via EGFR tyrosine kinase, could augment ANKIB1 activity by affecting its protein-protein interactions, thus impacting processes such as glucose metabolism or cell growth. Phorbol 12-myristate 13-acetate (PMA) activates PKC, which could indirectly enhance ANKIB1 activity through phosphorylation, influencing its role in membrane dynamics or cytoskeletal arrangements. IBMX, through inhibition of phosphodiesterases, raises cAMP and cGMP levels, which activate PKA and PKG, potentially enhancing ANKIB1's activity by affecting the phosphorylation state of ANKIB1 or its associated proteins. Lastly, Okadaic Acid, by inhibiting protein phosphatases PP1 and PP2A, may lead to a net increase in the phosphorylation of proteins within the cell, including ANKIB1 or its interacting partners, thereby potentiating ANKIB1's role in cellular signaling pathways. Collectively, these ANKIB1 Activators, through targeted modulation of signaling pathways, facilitate the elevation of ANKIB1-mediated cellular functions without the need for upregulating its expression or direct activation.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin activates adenylate cyclase, increasing intracellular cAMP levels. Elevated cAMP activates PKA, which may then phosphorylate and enhance the activity of ANKIB1 by modulating its interaction with binding partners or substrates within the cell, thus influencing the cellular pathways ANKIB1 is involved in. | ||||||
8-Bromo-cAMP | 76939-46-3 | sc-201564 sc-201564A | 10 mg 50 mg | $97.00 $224.00 | 30 | |
8-Bromoadenosine 3',5'-cyclic monophosphate (8-Br-cAMP) is a cell-permeable cAMP analog that activates PKA. PKA can then phosphorylate and enhance ANKIB1 activity similarly to Forskolin, by affecting its role in cytoskeletal organization and protein-protein interactions. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $76.00 $265.00 | 80 | |
Ionomycin is a calcium ionophore that increases intracellular calcium levels. The elevation of calcium can activate calcium-dependent protein kinases, which may potentially enhance ANKIB1 activity if ANKIB1 is a substrate of such kinases, thereby affecting its function in cellular signaling pathways associated with calcium signaling. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
PMA activates protein kinase C (PKC), which could enhance ANKIB1 activity through PKC-mediated phosphorylation if ANKIB1 is among its substrates. This phosphorylation could influence ANKIB1’s role in cellular processes like membrane trafficking or cytoskeletal organization. | ||||||
Insulin | 11061-68-0 | sc-29062 sc-29062A sc-29062B | 100 mg 1 g 10 g | $153.00 $1224.00 $12239.00 | 82 | |
Insulin activates the PI3K/Akt signaling pathway. Activation of this pathway could enhance the activity of ANKIB1 if ANKIB1 is involved in downstream signaling, possibly by affecting its interaction with other proteins and thus playing a role in processes like glucose uptake or glycogen synthesis. | ||||||
Dibutyryl-cAMP | 16980-89-5 | sc-201567 sc-201567A sc-201567B sc-201567C | 20 mg 100 mg 500 mg 10 g | $45.00 $130.00 $480.00 $4450.00 | 74 | |
Dibutyryl cAMP is another cell-permeable analog of cAMP that activates PKA. By increasing PKA activity, ANKIB1 activity could be enhanced if it is phosphorylated by PKA or if PKA modifies the activity of proteins that interact with ANKIB1, potentially affecting its role in signal transduction. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $54.00 $128.00 $199.00 $311.00 | 23 | |
A23187 is a calcium ionophore that, like Ionomycin, raises intracellular calcium levels. Elevated calcium can activate calmodulin-dependent kinases, potentially enhancing ANKIB1 activity by affecting its phosphorylation state or interactions with other proteins, thus influencing calcium-dependent cellular functions. | ||||||
Isoproterenol Hydrochloride | 51-30-9 | sc-202188 sc-202188A | 100 mg 500 mg | $27.00 $37.00 | 5 | |
Isoproterenol is a β-adrenergic agonist that increases intracellular levels of cAMP, leading to PKA activation. PKA-mediated phosphorylation could enhance ANKIB1 activity by modulating its cellular functions, such as its involvement in cellular signaling pathways related to adrenergic receptors. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $159.00 $315.00 $598.00 | 34 | |
IBMX is a non-specific inhibitor of phosphodiesterases, which prevents the breakdown of cAMP and cGMP, leading to their accumulation and the activation of their respective pathways. This can enhance the activity of ANKIB1 by increasing PKA or PKG activity, which may phosphorylate ANKIB1 or alter its interactions with other signaling proteins. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $94.00 $349.00 | 114 | |
Thapsigargin is a SERCA pump inhibitor that increases cytosolic calcium concentration. The resulting activation of calcium-dependent kinases could enhance ANKIB1 activity by influencing its phosphorylation or the phosphorylation of proteins that interact with ANKIB1, affecting its role in calcium signaling pathways. | ||||||