AKR7A3 Inhibitors
AKR7A3 inhibitors belong to a class of chemical compounds designed to selectively target and modulate the activity of the aldo-keto reductase 7A3 (AKR7A3) enzyme. AKR7A3 is a member of the aldo-keto reductase superfamily, which plays a crucial role in cellular detoxification processes. Specifically, AKR7A3 is involved in the reduction of aldehydes and ketones, contributing to the maintenance of cellular homeostasis by metabolizing a diverse range of endogenous and exogenous substrates. The inhibitors are designed to bind to the active site of AKR7A3, thereby obstructing its enzymatic activity and preventing the reduction of specific substrates.
AKR7A3 inhibitors exhibit a diverse range of chemical scaffolds, often characterized by functional groups that interact with key residues in the enzyme's active site. These inhibitors are meticulously engineered to achieve high selectivity for AKR7A3, minimizing off-target effects on other enzymes within the aldo-keto reductase superfamily. Researchers focus on optimizing the pharmacokinetic properties of these inhibitors to enhance their bioavailability and ensure efficient delivery to target tissues.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
D,L-Sulforaphane | 4478-93-7 | sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D | 5 mg 10 mg 25 mg 1 g 10 g 250 mg | $153.00 $292.00 $489.00 $1325.00 $8465.00 $933.00 | 22 | |
Interacts with Keap1, modifying cysteine residues and activating Nrf2 which can downregulate AKR7A3. | ||||||
Oltipraz | 64224-21-1 | sc-205777 sc-205777A | 500 mg 1 g | $286.00 $622.00 | ||
Modulates Nrf2 signaling, leading to altered transcription of detoxification enzymes including AKR7A3. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $110.00 $250.00 $936.00 $50.00 | 33 | |
Influences antioxidant response elements which may decrease AKR7A3 expression by modulating Nrf2 pathway. | ||||||
Dimethyl fumarate | 624-49-7 | sc-239774 | 25 g | $28.00 | 6 | |
Activates the Nrf2 pathway which has a secondary effect on the regulation of AKR7A3. | ||||||
Zinc | 7440-66-6 | sc-213177 | 100 g | $48.00 | ||
May disrupt metal ion homeostasis, indirectly affecting AKR7A3 enzyme activity. | ||||||
Disulfiram | 97-77-8 | sc-205654 sc-205654A | 50 g 100 g | $53.00 $89.00 | 7 | |
Alters the activity of aldehyde dehydrogenases which can indirectly affect AKR7A3. | ||||||
Chrysin | 480-40-0 | sc-204686 | 1 g | $38.00 | 13 | |
Has been shown to modulate Nrf2, potentially altering AKR7A3 expression. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Can influence the Nrf2 pathway and subsequently affect AKR7A3 expression. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Modulates several signaling pathways, including Nrf2, which can indirectly affect AKR7A3. | ||||||
Ellagic Acid, Dihydrate | 476-66-4 | sc-202598 sc-202598A sc-202598B sc-202598C | 500 mg 5 g 25 g 100 g | $58.00 $95.00 $245.00 $727.00 | 8 | |
Affects Nrf2 signaling pathway which may lead to altered expression of AKR7A3. | ||||||