AKR7A3 Activators
AKR7A3 activators refers to a class of chemical compounds that have the capacity to modulate the activity of the enzyme AKR7A3, a member of the aldo-keto reductase (AKR) superfamily. AKR7A3, also known as aldo-keto reductase family 7 member A3, is a cytosolic protein found in various tissues of the human body, with notably high expression levels in the liver, kidney, and lung. This enzyme plays a critical role in the detoxification and metabolism of endogenous and exogenous compounds, particularly by catalyzing the reduction of aldehydes and ketones. AKR7A3 activators are small molecules that bind to the enzyme and enhance its catalytic activity, often by stabilizing the active conformation or promoting the binding of substrates. These activators may be natural or synthetic in origin and can vary widely in their chemical structures.
Understanding the function of AKR7A3 activators is crucial in the context of xenobiotic metabolism, as this enzyme is involved in the detoxification of a broad range of potentially harmful compounds, including various environmental toxins and drugs. By enhancing the enzyme's activity, AKR7A3 activators have the potential to improve the efficiency of xenobiotic clearance and thereby mitigate their toxic effects on the body. Additionally, these compounds are of interest in research exploring the regulation of cellular redox balance, as AKR7A3 contributes to the maintenance of intracellular homeostasis by reducing reactive carbonyl species.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
NADPH tetrasodium salt | 2646-71-1 | sc-202725 sc-202725A sc-202725B sc-202725C | 25 mg 50 mg 250 mg 1 g | $46.00 $82.00 $280.00 $754.00 | 11 | |
Serves as a co-factor required for AKR7A3 enzyme activity. It directly participates in the enzyme's catalytic process, facilitating the reduction of aldehydes to alcohols. | ||||||
L-Ascorbic acid, free acid | 50-81-7 | sc-202686 | 100 g | $45.00 | 5 | |
Indirectly activates AKR7A3 by acting as an antioxidant. It reduces oxidative stress, which can influence the expression and activity of detoxifying enzymes, including AKR7A3. | ||||||
(+)-α-Tocopherol | 59-02-9 | sc-214454 sc-214454A sc-214454B | 10 g 25 g 100 g | $42.00 $61.00 $138.00 | ||
Indirectly activates AKR7A3 by acting as an antioxidant. Its antioxidant properties can impact detoxification pathways and enhance the enzyme's activity. | ||||||
Cobalt(II) chloride | 7646-79-9 | sc-252623 sc-252623A | 5 g 100 g | $63.00 $173.00 | 7 | |
Indirectly activates AKR7A3 by modulating HIF-1α (Hypoxia-inducible factor 1-alpha), which can affect the expression of detoxifying enzymes. This indirectly enhances AKR7A3 activity. | ||||||
Glutathione, reduced | 70-18-8 | sc-29094 sc-29094A | 10 g 1 kg | $76.00 $2050.00 | 8 | |
Indirectly activates AKR7A3 by providing a key substrate for the detoxification process. It supports the enzyme's role in the metabolism of aldehydes and other toxic compounds. | ||||||
5-Aza-2′-Deoxycytidine | 2353-33-5 | sc-202424 sc-202424A sc-202424B | 25 mg 100 mg 250 mg | $214.00 $316.00 $418.00 | 7 | |
Indirectly activates AKR7A3 by demethylating DNA, potentially influencing the gene regulation of the enzyme. This epigenetic modification can enhance AKR7A3 expression. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
Indirectly activates AKR7A3 by inhibiting histone deacetylases. This epigenetic modulation can affect the expression of the enzyme, enhancing its activity through changes in gene regulation. | ||||||