AIDA Activators
AIDA Activators represent a unique class of chemicals designed to influence the functionality of the Axin interactor, dorsalization-associated protein (AIDA). As a pivotal component in the Wnt signaling pathway, AIDA's interaction with key cellular players, particularly Axin, determines the outcome of numerous cellular events. By targeting AIDA directly or indirectly, these activators can steer its regulatory functions, ensuring a more pronounced effect on the cascade of intracellular activities governed by the Wnt pathway.
Lithium chloride, for instance, disrupts the GSK-3β activity, a kinase that often forms complexes with Axin. This disruption can lead to the stabilization of β-catenin, indirectly promoting AIDA's function in the pathway. On the other hand, purmorphamine directly interacts with the Smoothened receptor, influencing the downstream signaling events, including those associated with AIDA. 5-Azacytidine, a DNA methyltransferase inhibitor, can modify the gene expression profile within cells, offering another avenue to modulate AIDA's role in Wnt signaling. SKL2001 directly targets β-catenin, preventing its degradation and amplifying the signaling. Given AIDA's pivotal position in these pathways, its modulation by such activators presents an avenue to influence the broader cascade of events in the Wnt pathway.
Items 1 to 10 of 11 total
Display:
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
LiCl inhibits GSK3β. When GSK3β is inhibited, it leads to the accumulation of β-catenin and activates Wnt signaling. This can indirectly affect AIDA's interaction with Axin, modulating the signaling cascade. | ||||||
SB-216763 | 280744-09-4 | sc-200646 sc-200646A | 1 mg 5 mg | $71.00 $202.00 | 18 | |
This GSK3β inhibitor promotes Wnt signaling by preventing β-catenin degradation. Enhanced Wnt signaling can modulate AIDA's interactions, given its role in the pathway. | ||||||
GSK-3 Inhibitor IX | 667463-62-9 | sc-202634 sc-202634A sc-202634B | 1 mg 10 mg 50 mg | $58.00 $188.00 $884.00 | 10 | |
GSK-3 Inhibitor IX activates the Wnt/β-catenin pathway. The amplified signaling might influence AIDA's function in the pathway cascade. | ||||||
SKL2001 | 909089-13-0 | sc-507410 | 10 mg | $123.00 | ||
By directly activating Wnt/β-catenin signaling through β-catenin stabilization, SKL2001 can potentially modulate the interactions AIDA has within this pathway. | ||||||
IWP-2 | 686770-61-6 | sc-252928 sc-252928A | 5 mg 25 mg | $96.00 $292.00 | 27 | |
By inhibiting Porcupine, IWP-2 affects Wnt secretion. Altering Wnt availability can indirectly impact the cascade in which AIDA plays a role. | ||||||
Wnt-C59 | 1243243-89-1 | sc-475634 sc-475634A sc-475634B | 5 mg 10 mg 50 mg | $214.00 $326.00 $1275.00 | 1 | |
Affecting Wnt secretion by inhibiting Porcupine, Wnt-C59 can indirectly influence the signaling dynamics where AIDA operates. | ||||||
XAV939 | 284028-89-3 | sc-296704 sc-296704A sc-296704B | 1 mg 5 mg 50 mg | $36.00 $117.00 $525.00 | 26 | |
XAV-939 stabilizes Axin. Since AIDA interacts with Axin, the chemical can indirectly alter this interaction by influencing Axin availability in the Wnt pathway. | ||||||
IWR-1-endo | 1127442-82-3 | sc-295215 sc-295215A | 5 mg 10 mg | $82.00 $135.00 | 19 | |
IWR-1 stabilizes Axin. A change in Axin dynamics, a protein AIDA interacts with, can influence AIDA's function in the signaling cascade. | ||||||
GSK-3 Inhibitor XVI | 252917-06-9 | sc-221691 sc-221691A | 5 mg 25 mg | $180.00 $610.00 | 4 | |
GSK-3 Inhibitor XVI enhances Wnt signaling. This strengthened signal can indirectly modulate AIDA's role and interactions. | ||||||
JW 55 | 664993-53-7 | sc-364517 sc-364517A | 10 mg 50 mg | $172.00 $726.00 | ||
JW55 affects the Wnt pathway by inhibiting tankyrase's PARP domain. This modulation can indirectly affect AIDA's dynamics in the pathway. | ||||||