Molecular structure of GSK-3 Inhibitor XVI, CAS Number: 252917-06-9
GSK-3 Inhibitor XVI (CAS 252917-06-9)
See product citations (4)
Alternate Names:
GSK-3 Inhibitor XVI is also known as CHIR99021.
Application:
GSK-3 Inhibitor XVI is a compound that acts as potent, ATP-competitive & highly selective GSK-3 inhibitor.
CAS Number:
252917-06-9
Purity:
≥98%
Molecular Weight:
465.34
Molecular Formula:
C22H18Cl2N8
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
GSK-3 Inhibitor XVI is a cell-permeable aminopyrimidine compound that acts as potent, ATP-competitive, and highly selective GSK-3 inhibitor (IC50 = 10 and 6.7 nM against GSK-3α and GSK-3β, respectively). GSK-3 Inhibitor XVI exhibits little to no activity toward 46 other enzymes (IC50 >8.8 µM against 20 kinases and Ki ≥5 μM against 23 non-kinase enzymes) and shows only weak binding to 22 pharmacologically relevant receptors (Kd ~4 μM). GSK-3 Inhibitor XVI is bioavailable via oral ingestion and has shown to improve in vivo glucose metabolism in both murine and rat type 2 diabetes models.
GSK-3 Inhibitor XVI (CAS 252917-06-9) References
- GSK-3β is essential for physiological electric field-directed Golgi polarization and optimal electrotaxis. | Cao, L., et al. 2011. Cell Mol Life Sci. 68: 3081-93. PMID: 21207103
- Chromatin PTEN is involved in DNA damage response partly through regulating Rad52 sumoylation. | Choi, BH., et al. 2013. Cell Cycle. 12: 3442-7. PMID: 24047694
- Analysis of Wnt signalling dynamics during colon crypt development in 3D culture. | Tan, CW., et al. 2015. Sci Rep. 5: 11036. PMID: 26087250
- Phosphorylation of the chromatin remodeling factor DPF3a induces cardiac hypertrophy through releasing HEY repressors from DNA. | Cui, H., et al. 2016. Nucleic Acids Res. 44: 2538-53. PMID: 26582913
- Positive cross talk between protein kinase D and β-catenin in intestinal epithelial cells: impact on β-catenin nuclear localization and phosphorylation at Ser552. | Wang, J., et al. 2016. Am J Physiol Cell Physiol. 310: C542-57. PMID: 26739494
- Zeb1-Hdac2-eNOS circuitry identifies early cardiovascular precursors in naive mouse embryonic stem cells. | Cencioni, C., et al. 2018. Nat Commun. 9: 1281. PMID: 29599503
- Derivation and molecular characterization of pancreatic differentiated MODY1-iPSCs. | Braverman-Gross, C., et al. 2018. Stem Cell Res. 31: 16-26. PMID: 29990710
- Mitotic chromosome binding predicts transcription factor properties in interphase. | Raccaud, M., et al. 2019. Nat Commun. 10: 487. PMID: 30700703
- A KO mouse model for the lncRNA Lhx1os produces motor neuron alterations and locomotor impairment. | Pellegrini, F., et al. 2023. iScience. 26: 105891. PMID: 36647387
Inhibitor of:
αPIX, δ-catenin, 2410066E13Rik, 2610208M17Rik, 4933403O03Rik, AFAP-1L2, ALS2CR4, Ameloblastin, AP-2ε, ARMC7, ARX, ASCL5, ATF-5, BC061212, BHLHA9, brachyury 2, BRSK1, BVES, C030037F17Rik, C030039L03Rik, C130079G13Rik, C1orf80, C230072F16Rik, C2orf48, C78339, CASZ1, CCDC89, CLASP (Cytoplasmic Linker Associated Protein), CREG2, Cypt6, CYYR1, D630037F22Rik, D6Mm5e, D830030K20Rik, Daf2, DAPLE, DBX2, DCC, DDX12, Dlx-5, DMRT2, DPPA2, E130120F12Rik, EG237300, EG626456, EG627352, EMX (Empty Spiracles Homeobox), ESC, FAM48B2, FBXW26, FGD1, FHL-2, follistatin, Forkhead box N (FOXN), FOXB2, FOXC2, FOXD4, FOXD4L2, FOXD4L6, FOXN1, FREM2, Freud-1, Gas7, GBX2, GCK, GCP5, GPRC5B, GSK-3 alpha, GSKIP, Hairless, HB9, HOP-1, HoxA1, HoxC11, HoxD4, HR, IFFO2, JTB, Krüppel-like factor (KLF), LGR6, LMX1B, LZTFL1, MATH-2, MDFIC, MINK1, Morc4, MREG, musculin, MycN, Myosin XVI, N-cadherin, NanogNB, nArgBP2, NBPF, Nkx-2.5, Nkx-6.3, Olfr477, Olfr482, Olfr483, Olfr484, Olfr553, Olfr554, Olfr555, Olfr556, Olfr557, Olfr648, OLIG3, OR6P1, OSR2, Otolin-1, OTTMUSG00000011339, OTTMUSG00000011350, P1 Adhesion, PCDH9_Pcdh9, PCDHB1, PCDHB2, PCDHGA10, PERQ1, PIG-T, Pitx2, Pitx3, POD-1, POPX1, PTF1, Rab 39A, RBFOX3/NeuN, Rex-1, RFLAT-1, Rho F, Rhox3c, RIA1, Ripply1, SEBOX, Six2, SOX (SRY-box transcription factor), Sox-22, Sox19, TBC1D10B, TBX1, TBX20, TBX6, TCF23, Tctex1, Teneurin-3, TNIK, UNCX, VSX1, WDPCP, X11γ, YSK1, ZBTB5, Zic3, ZNF205, ZNF206, ZNF597, ZNF687, ZNF853, ZNRF1, and ZSCAN2.Activator of:
4931431F19Rik, 6330545A04Rik, ADP ribosylation factor (ARF), AIDA, AP1GBP1, ArgBP2, Armadillo (β-catenin), ASCL3, ASCL4, BAF155, BAF170, BAR-1, Barx2, BLOS1, BMP-3, BMP-9, brachyury, C030048H21Rik, C130039O16Rik, C17orf83, C230078M14Rik, casein kinase Iγ1, Chibby, CMV pp65, Collapsin response mediator protein (CRMP), Conductin, CRIM1, Crumbs, CUG-BP2, D230039L06Rik, D630045J12Rik, D6Mm5e, D930020B18Rik, dishevelled, Diversin, DIXDC1, Dkk-2, Dkk-3, Dynein Light Chain, E-cadherin, E130309D02Rik, EG435337, EG626215, engrailed, ephrin-B2, Evx-1, eyes absent, FAM83D, FGF-18, Flamingo, FLJ13231, FOXD4, fringe, frizzled-1, frizzled-2, frizzled-3, frizzled-6, frizzled-8, frizzled-9, FXR2, glycogen synthase 1, GOLGA6A-D, GPR177, HES1, HES5, HRT3, ICAT, IFT172, IFT46, IL-5, IL-7, INTU, IRX4, ITM2A, KIAA1737, Kinectin 1, Kremen-1, Kremen-2, L1TD1, LEF-1, Lefty-1, Lefty-A, Lefty-B, LGR4, LHX2, LHX4, LI-cadherin, LIN-31, Lipocalin-8, Liprin α1, LRG-47, LRP5, LRRC29, LRRC36, LRRC37A, Ly-6G, Manic Fringe, MEF-2C, Mesogenin 1, MESP2, MFSD6, Mxi1, Myosin Vc, Nanog, Neurotrypsin, NKD2, Nkx-2.2, nudel, Nup214, Oct-3/4, oskar, Paraxis, Pax-6, Peg1, plexin-A4, POU3F3 (Brn-1), Prickle1, Prickle4, Pygopus 1, R-Spondin, R-Spondin2, R-Spondin4, RAI15, Ribosomal Protein L11, SAP 14_SF3B14, Septin 6, SHOX2A, Six3, Snf5, Sox-17, Sox-2, Sox-7, Sp5, SPT5, SSEA-1, SSEA-4, TCF-1, TCF-4, TCL-6, TIGD7, TLE2, TMEM46, TSHZ1, TTBK2, UTF1, Vangl1, Vangl2, vezatin, VRTN, WDR5, Wingless, Wnt-1, Wnt-10b, Wnt-11, Wnt-14, Wnt-14b, Wnt-15, Wnt-16, Wnt-2b, Wnt-5a, Wnt-6, Wnt-8b, XRN1, ZC3HDC3, ZNF236, ZNF281, ZNF643, and ZSWIM6.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
GSK-3 Inhibitor XVI, 5 mg | sc-221691 | 5 mg | $153.00 | |||
GSK-3 Inhibitor XVI, 25 mg | sc-221691A | 25 mg | $520.00 |