Abi-2 Inhibitors
Abi-2 inhibitors belong to a class of chemical compounds designed to target and modulate the activity of the Abi-2 protein, also known as Abl interactor 2. Abi-2 is a cytoplasmic protein that plays a pivotal role in various cellular processes, particularly in regulating cytoskeletal dynamics and cell migration. It is part of the WAVE complex, which is essential for actin polymerization and the formation of lamellipodia and filopodia, cellular structures involved in cell motility and shape changes. Abi-2 is also known to interact with multiple signaling pathways, making it a key player in cellular responses to extracellular cues. Inhibitors developed to target Abi-2 are primarily employed in molecular and cellular biology research to investigate the functional properties and regulatory mechanisms associated with this protein.
The development of Abi-2 inhibitors typically involves a combination of biochemical, biophysical, and structural approaches aimed at identifying or designing molecules that can selectively interact with Abi-2 and modulate its activity within the cellular cytoskeletal network. By inhibiting Abi-2, these compounds can disrupt its role in actin polymerization and cellular migration, influencing cellular processes dependent on cytoskeletal dynamics. Researchers use Abi-2 inhibitors to explore the intricate roles played by this protein in cellular functions, attempting to unravel its contributions to cell motility, adhesion, and responses to environmental cues. Furthermore, these inhibitors serve as valuable tools for dissecting the broader network of cellular pathways involving Abi-2 and its interactions with other regulatory proteins, contributing to our understanding of fundamental cell biology mechanisms and providing insights into avenues for further scientific exploration.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Triptolide | 38748-32-2 | sc-200122 sc-200122A | 1 mg 5 mg | $88.00 $200.00 | 13 | |
Triptolide may inhibit transcription factors and lead to reduced expression of many genes, potentially including Abi-2. | ||||||
Flavopiridol | 146426-40-6 | sc-202157 sc-202157A | 5 mg 25 mg | $78.00 $254.00 | 41 | |
Flavopiridol inhibits cyclin-dependent kinases and might suppress transcriptional elongation affecting Abi-2 gene expression. | ||||||
Betulinic Acid | 472-15-1 | sc-200132 sc-200132A | 25 mg 100 mg | $115.00 $337.00 | 3 | |
As a regulator of gene expression, betulinic acid could theoretically downregulate Abi-2 transcription in certain cell types. | ||||||
Chetomin | 1403-36-7 | sc-202535 sc-202535A | 1 mg 5 mg | $182.00 $661.00 | 10 | |
Chetomin disrupts the function of hypoxia-inducible factors which might reduce transcription of hypoxia-responsive genes like Abi-2. | ||||||
C646 | 328968-36-1 | sc-364452 sc-364452A | 10 mg 50 mg | $260.00 $925.00 | 5 | |
C646 is a p300 histone acetyltransferase inhibitor and could affect acetylation patterns, potentially reducing Abi-2 expression. | ||||||
(±)-JQ1 | 1268524-69-1 | sc-472932 sc-472932A | 5 mg 25 mg | $226.00 $846.00 | 1 | |
JQ1 inhibits BET bromodomain proteins, which could downregulate transcription factors responsible for Abi-2 expression. | ||||||
I-CBP112 | 1640282-31-0 | sc-507494 | 25 mg | $400.00 | ||
This compound is designed to inhibit CBP/p300 and may reduce the expression of proteins like Abi-2 at the transcriptional level. | ||||||
MS-275 | 209783-80-2 | sc-279455 sc-279455A sc-279455B | 1 mg 5 mg 25 mg | $24.00 $88.00 $208.00 | 24 | |
MS-275 is a histone deacetylase inhibitor and might modulate chromatin structure, potentially decreasing Abi-2 expression. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $108.00 $245.00 $918.00 $49.00 | 33 | |
Quercetin has been shown to influence gene expression patterns and might theoretically downregulate Abi-2 transcription. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Sirolimus inhibits mTOR and could have downstream effects on protein synthesis, possibly affecting Abi-2 expression indirectly. | ||||||