Molecular structure of Chetomin, CAS Number: 1403-36-7
Chetomin (CAS 1403-36-7)
See product citations (10)
Alternate Names:
Chaetomin; NSC 289491
Application:
Chetomin is an antibacterial agent and inhibitor of HIF
CAS Number:
1403-36-7
Purity:
≥90%
Molecular Weight:
710.86
Molecular Formula:
C31H30N6O6S4
Supplemental Information:
This is as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Chetomin is reported to be an antibiotic metabolite of Chaetomium spp. which contains bacteriostatic effects on Gram-positive bacteria. Mechanistic studies suggest that Chetomin inhibits the division and separation of cells in cultures of B. fibrisolvens D1. Chetomin inhibits HIF (hypoxia-inducing factor) binding to the transcriptional coactivator p300. Chetomin disruption of HIF is believed to be done via a change in the structure of the CH1 domain of p300 which prevents interaction with HIF-1alpha and HIF-2alpha. Inhibition of this interaction has been reported to attenuate hypoxia-inducible transcription.
Chetomin (CAS 1403-36-7) References
- Immunomodulatory constituents from an Ascomycete, Chaetomium seminudum. | Fujimoto, H., et al. 2004. J Nat Prod. 67: 98-102. PMID: 14738397
- Small molecule blockade of transcriptional coactivation of the hypoxia-inducible factor pathway. | Kung, AL., et al. 2004. Cancer Cell. 6: 33-43. PMID: 15261140
- Effects of HIF-1 inhibition by chetomin on hypoxia-related transcription and radiosensitivity in HT 1080 human fibrosarcoma cells. | Staab, A., et al. 2007. BMC Cancer. 7: 213. PMID: 17999771
- HIF-1α inhibition by siRNA or chetomin in human malignant glioma cells: effects on hypoxic radioresistance and monitoring via CA9 expression. | Kessler, J., et al. 2010. BMC Cancer. 10: 605. PMID: 21050481
- Chetomin induces degradation of XIAP and enhances TRAIL sensitivity in urogenital cancer cells. | Yano, K., et al. 2011. Int J Oncol. 38: 365-74. PMID: 21165560
- Enhanced antitumor activity and mechanism of biodegradable polymeric micelles-encapsulated chetomin in both transgenic zebrafish and mouse models. | Wu, Q., et al. 2014. Nanoscale. 6: 11940-52. PMID: 25175172
- Inhibition of hypoxia-inducible factor-1 alpha radiosensitized MG-63 human osteosarcoma cells in vitro. | Jin, Z., et al. 2015. Tumori. 101: 578-84. PMID: 26350185
- Chetomin, targeting HIF-1α/p300 complex, exhibits antitumour activity in multiple myeloma. | Viziteu, E., et al. 2016. Br J Cancer. 114: 519-23. PMID: 26867162
- A new epipolythiodioxopiperazine with antibacterial and cytotoxic activities from the endophytic fungus Chaetomium sp. M336. | Yu, FX., et al. 2018. Nat Prod Res. 32: 689-694. PMID: 28602097
- Chetomin induces apoptosis in human triple-negative breast cancer cells by promoting calcium overload and mitochondrial dysfunction. | Dewangan, J., et al. 2018. Biochem Biophys Res Commun. 495: 1915-1921. PMID: 29208466
- Chetomin, a Hsp90/HIF1α pathway inhibitor, effectively targets lung cancer stem cells and non-stem cells. | Min, S., et al. 2020. Cancer Biol Ther. 21: 698-708. PMID: 32489150
- Chetomin rescues pathogenic phenotype of LRRK2 mutation in drosophila. | Chua, LL., et al. 2020. Aging (Albany NY). 12: 18561-18570. PMID: 32990658
- Mathematical description of the effect of HIF inhibition on the radiobiological response of LNCaP cells. | Azorín-Vega, EP., et al. 2022. Appl Radiat Isot. 184: 110157. PMID: 35278999
- Chetomin, a SARS-CoV-2 3C-like Protease (3CLpro) Inhibitor: In Silico Screening, Enzyme Docking, Molecular Dynamics and Pharmacokinetics Analysis. | Ibrahim, MAA., et al. 2023. Viruses. 15: PMID: 36680290
- Effects of chetomin on growth and acidic fermentation products of rumen bacteria. | Jen, WC. and Jones, GA. 1983. Can J Microbiol. 29: 1399-404. PMID: 6686488
Inhibitor of:
β-1,3-Gal-TL, 2700081O15Rik, Abi-2, APJR-1, ARGFX, Arnt 2, Basonuclin 2, BLP1, BMAL2, BTF3L2, Bystin, C13orf30, C14orf132, CDIP, CLCA, CMG1, CPA6, CPXM, CSN4, DCBLD1, Dlx-6, Dynactin p135, EG668381, FEV, FOXD4L1, FOXF1, FOXI1, FOXL1, FPGT, GalNAc-T9, GLIS1, GOLGA8B, Gvin1, H1FOO, H1T2, HID, HIF, HIF PHD3, HIF-1 alpha, HIF-3α, Histone cluster 2 H3B, hnRNP R, HNRNPA1L2, IFITM6, IL-2Rγ, ILDR2, Islet-2, Kctd12b, KRAB4, KRTAP8-2, KV4.1, L-Alkaline phosphatase, LDLRAD1, LDOC1L, LEUNIG, LHX9, LIPI, LOC100039210, LOC100039763, LOC100039799, LOC100041032, LOC642361, LOXL4, LYSMD3, MACF1-4, MATH-5, Mettl7a2-Higd1c, MGAT3, MICB, MOCS1, Msx-1, Munc13-2, Neuromedin N, NgBR, Nkx-2.4, NPDC-1, OGFR, OTP, Paired Box (PAX), Pancreasin, Pax-6, PAX9, PHD (peptidyl-proline 4-dioxygenase), PHF6, PICT-1, pki γ, PLAC8, POU6F2, PPIAL4D, PRAMEF6, Reptin 52, RFX1, Rhox1, SAPAP3, Sarcalumenin, Six4, Sox-14, SOXN, SPT20L2, Stra13, SUSD5, SWI5, TAFII-28, THTR2, Tim14, TMPRSS11D, Treacle, Trim12c, TSSC3, TTF, Twinfilin-1, UNC5H4, WBSCR19, WFDC1A, WFDC1B, YAF2, ZBED5, Zfp738, ZFP94, ZFR, Zic2, ZNF157, ZNF215, ZNF330, ZNF41, ZNF454, ZNF483, ZNF511, ZNF518, ZNF580, ZNF642, ZNF660, ZNF673, ZNF697, ZNF75, ZNF774, ZNF860, and ZPI.Activator of:
FOXE2, HIGD1B, LDHA, LDHB, and Tctex1D1.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Chetomin, 1 mg | sc-202535 | 1 mg | $186.00 | |||
Chetomin, 5 mg | sc-202535A | 5 mg | $674.00 |