Abca8a Activators
Chemical activators of ATP-binding cassette, sub-family A member 8a can induce its function through various biochemical pathways. A23187 and Ionomycin serve as calcium ionophores that facilitate the import of calcium ions into the cell. This increase in intracellular calcium concentration can activate downstream kinases, such as calcium-dependent protein kinases, which in turn can phosphorylate ATP-binding cassette, sub-family A member 8a, enhancing its ATPase activity. Similarly, Thapsigargin disrupts calcium homeostasis by inhibiting the SERCA pump, leading to a rise in cytosolic calcium levels, which may also result in the activation of kinases that phosphorylate ATP-binding cassette, sub-family A member 8a.
Other chemicals manipulate signaling pathways to activate ATP-binding cassette, sub-family A member 8a via phosphorylation. Phorbol 12-myristate 13-acetate (PMA) and Prostratin are known to activate protein kinase C (PKC), which can then phosphorylate ATP-binding cassette, sub-family A member 8a. Forskolin, by stimulating adenylyl cyclase, increases the production of cAMP, which activates protein kinase A (PKA). PKA can then phosphorylate and activate ATP-binding cassette, sub-family A member 8a. Analogously, cell-permeable cAMP analogs like 8-Bromo-cAMP and Dibutyryl-cAMP also raise intracellular cAMP levels, leading to PKA activation. Phosphorylation by PKA promotes the activation of ATP-binding cassette, sub-family A member 8a. Furthermore, Okadaic acid and Calyculin A inhibit protein phosphatases such as PP1 and PP2A, prolonging the phosphorylated state of proteins, including ATP-binding cassette, sub-family A member 8a, thus sustaining its activation. Fusicoccin's mechanism involves stabilizing interactions between 14-3-3 proteins and kinases, which may lead to phosphorylation and activation of ATP-binding cassette, sub-family A member 8a. Lastly, Brefeldin A disrupts the Golgi apparatus, which can affect the localization and function of ATP-binding cassette, sub-family A member 8a, contributing to its activation state.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $55.00 $131.00 $203.00 $317.00 | 23 | |
A23187 acts as an ionophore that specifically transports calcium ions across membranes. The influx of calcium ions can activate downstream calcium-dependent protein kinases that, in turn, could activate ATP-binding cassette, sub-family A member 8a by phosphorylation or by inducing conformational changes that enhance its ATPase activity. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $78.00 $270.00 | 80 | |
Ionomycin is another calcium ionophore that elevates intracellular calcium levels. Elevated calcium can activate calmodulin-dependent kinase, which may phosphorylate and activate ATP-binding cassette, sub-family A member 8a. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
PMA activates protein kinase C (PKC), which is known to phosphorylate a wide array of proteins. PKC-mediated phosphorylation can lead to the functional activation of ATP-binding cassette, sub-family A member 8a by enhancing its ATPase activity. | ||||||
8-Bromo-cAMP | 76939-46-3 | sc-201564 sc-201564A | 10 mg 50 mg | $126.00 $328.00 | 30 | |
As a cell-permeable cAMP analog, 8-Bromo-cAMP can activate PKA. Activation of PKA may lead to the phosphorylation and functional activation of ATP-binding cassette, sub-family A member 8a. | ||||||
Dibutyryl-cAMP | 16980-89-5 | sc-201567 sc-201567A sc-201567B sc-201567C | 20 mg 100 mg 500 mg 10 g | $47.00 $136.00 $492.00 $4552.00 | 74 | |
Another cAMP analog, Dibutyryl-cAMP activates PKA. PKA activation may promote the phosphorylation and functional activation of ATP-binding cassette, sub-family A member 8a. | ||||||
Okadaic Acid | 78111-17-8 | sc-3513 sc-3513A sc-3513B | 25 µg 100 µg 1 mg | $291.00 $530.00 $1800.00 | 78 | |
Okadaic acid inhibits protein phosphatases PP1 and PP2A, leading to increased phosphorylation levels of cellular proteins. This inhibition may result in sustained phosphorylation and activation of ATP-binding cassette, sub-family A member 8a. | ||||||
Calyculin A | 101932-71-2 | sc-24000 sc-24000A | 10 µg 100 µg | $163.00 $800.00 | 59 | |
Calyculin A, like okadaic acid, is a potent inhibitor of protein phosphatases. By preventing dephosphorylation, it can contribute to the activation of ATP-binding cassette, sub-family A member 8a. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $136.00 $446.00 | 114 | |
Thapsigargin inhibits the SERCA pump leading to increased cytosolic calcium, which can activate calcium-dependent kinases that might phosphorylate and activate ATP-binding cassette, sub-family A member 8a. | ||||||
Prostratin | 60857-08-1 | sc-203422 sc-203422A | 1 mg 5 mg | $141.00 $541.00 | 24 | |
Prostratin activates PKC, which can phosphorylate and activate ATP-binding cassette, sub-family A member 8a, enhancing its function. | ||||||
Fusicoccin | 20108-30-9 | sc-200754 sc-200754A sc-200754B | 1 mg 5 mg 10 mg | $416.00 $2081.00 $4162.00 | 7 | |
Fusicoccin stabilizes the interaction between 14-3-3 proteins and their target proteins, which may include kinases that phosphorylate and activate ATP-binding cassette, sub-family A member 8a. | ||||||