Molecular structure of Fusicoccin, CAS Number: 20108-30-9
Fusicoccin (CAS 20108-30-9)
See product citations (7)
Application:
Fusicoccin is a toxin that complexes with 14-3-3 , causes cell hyperpolarization and is and activator of H(+)-ATPase
CAS Number:
20108-30-9
Purity:
≥90%
Molecular Weight:
680.82
Molecular Formula:
C36H56O12
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Fusicoccin, originally found in Fusicoccum amygdali Del., is shown to be an activator of H(+)-ATPase. Mechanistic studies suggest that Fusicoccin forms a complex with the 14-3-3 proteins of the ATPase and activates H+ pumping across the plasma membrane. Fusicoccin displays toxic characteristics towards cells by increasing the rate of proton extrusion, causing acidification of the surrounding of the cell and hyperpolarization of the cell. Other experiments demonstrate that the Fusicoccin toxin also induces stimulation of H2O2 production and leakage of cytochrome c from the mitochondria which results in disturbance of the electron transport chain of the mitochondrial membrane.
Fusicoccin (CAS 20108-30-9) References
- Fusicoccin signaling reveals 14-3-3 protein function as a novel step in left-right patterning during amphibian embryogenesis. | Bunney, TD., et al. 2003. Development. 130: 4847-58. PMID: 12930777
- Fusicoccin affects cytochrome c leakage and cytosolic 14-3-3 accumulation independent of H-ATPase activation. | Malerba, M., et al. 2004. Physiol Plant. 120: 386-394. PMID: 15032835
- Reactive Carbonyl Species Inhibit Blue-Light-Dependent Activation of the Plasma Membrane H+-ATPase and Stomatal Opening. | Murakami, N., et al. 2022. Plant Cell Physiol. 63: 1168-1176. PMID: 35786727
- Blocked at the Stomatal Gate, a Key Step of Wheat Stb16q-Mediated Resistance to Zymoseptoria tritici. | Battache, M., et al. 2022. Front Plant Sci. 13: 921074. PMID: 35832231
- Genome Analyses of Two Blueberry Pathogens: Diaportheamygdali CAA958 and Diaporthe eres CBS 160.32. | Hilário, S., et al. 2022. J Fungi (Basel). 8: PMID: 36012791
- Structure-activity-relationship study of semi-synthetically modified fusicoccins on their stabilization effect for 14-3-3-phospholigand interactions. | Ogino, N., et al. 2022. Bioorg Med Chem. 73: 117020. PMID: 36182801
- 14-3-3 proteins are luciferases candidate proteins from lanternfish Diaphus watasei. | Yano, D., et al. 2023. Photochem Photobiol Sci. 22: 263-277. PMID: 36197650
- Fusicoccin-A Targets Cancerous Inhibitor of Protein Phosphatase 2A by Stabilizing a C-Terminal Interaction with 14-3-3. | Brink, HJ., et al. 2022. ACS Chem Biol. 17: 2972-2978. PMID: 36255265
- Phytophthora infestans RxLR Effector PITG06478 Hijacks 14-3-3 to Suppress PMA Activity Leading to Necrotrophic Cell Death. | Seo, YE., et al. 2023. Mol Plant Microbe Interact. 36: 150-158. PMID: 36413345
- Biosensing on acid: fluorescent protein probes for low pH environments. | Bell, C., et al. 2022. J Exp Bot. 73: 7199-7203. PMID: 36478082
- Acid waters in tank bromeliads: Causes and potential consequences. | North, GB., et al. 2023. Am J Bot. 110: e16104. PMID: 36571428
- The Phytophthora capsici RxLR effector CRISIS2 triggers cell death via suppressing plasma membrane H+-ATPase in the host plant. | Seo, YE., et al. 2023. J Exp Bot. 74: 1675-1689. PMID: 36571808
- Hypoxic preconditioning promotes galvanotaxis of human dermal microvascular endothelial cells through NF-κB pathway. | Zhang, Z., et al. 2022. Heliyon. 8: e12421. PMID: 36643317
- Fusicoccin binding to its plasma membrane receptor and the activation of the plasma membrane H(+)-ATPase. IV. Fusicoccin induces the association between the plasma membrane H(+)-ATPase and the fusicoccin receptor. | Olivari, C., et al. 1998. Plant Physiol. 116: 529-37. PMID: 9489010
- The 14-3-3 proteins associate with the plant plasma membrane H(+)-ATPase to generate a fusicoccin binding complex and a fusicoccin responsive system. | Baunsgaard, L., et al. 1998. Plant J. 13: 661-71. PMID: 9681008
Inhibitor of:
14-3-3 β, 14-3-3 ε, 14-3-3 ζ, ENY2, Integrin β4, pan 14-3-3, Pma1, ZFP62, and ZFP869.Activator of:
2810008M24Rik, 2810011L19Rik, 4931408C20Rik, ABCA17, Abca8a, BC023829, CCDC30, COG5, demethylated-PP2A-C, erasin, FAM48B2, FAM75A3, FAM75C1, FAM75D4, GNL3L, GPSM3, IRGC1, KIAA0141, Mbp1, ORF67, OTTMUSG00000010173, PAK6, Pbx2, PDZK4, SPCS3, TDF, TMEM146, Tmem217, Trav13d-3, Trav13n-1, Trav14n-3, Trav16dv11, Trav4n-3, Trav5n-4, Trav6d-5, Trav7d-2, Trav8d-1, Trav9n-3, TRBV3, V-ATPase F, and WDR22.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Fusicoccin, 1 mg | sc-200754 | 1 mg | $416.00 | |||
Fusicoccin, 5 mg | sc-200754A | 5 mg | $2081.00 | |||
Fusicoccin, 10 mg | sc-200754B | 10 mg | $4162.00 |