8-OHdG Inhibitors
Common 8-OHdG Inhibitors include, but are not limited to N-Acetyl-L-cysteine CAS 616-91-1, 5,7-Dihydroxy-4-methylcoumarin CAS 2107-76-8, Baicalein CAS 491-67-8, DL-α-Tocopherol CAS 10191-41-0 and Tiron CAS 149-45-1.
8-OHdG inhibitors belong to a class of compounds designed to modulate the levels of 8-hydroxy-2'-deoxyguanosine (8-OHdG), a modified nucleoside that results from the oxidation of guanine in DNA. This chemical modification can occur as a consequence of oxidative stress, DNA damage, or exposure to reactive oxygen species. Elevated levels of 8-OHdG are often associated with cellular and molecular damage, as it can lead to mutations and genomic instability. By targeting the mechanisms underlying the formation of 8-OHdG or its subsequent effects, these inhibitors aim to mitigate the harmful consequences of oxidative damage to DNA.
Research on 8-OHdG inhibitors contributes to our understanding of the intricate pathways involved in DNA repair, oxidative stress responses, and genomic stability. These inhibitors are valuable tools for probing the role of 8-OHdG in various cellular processes. By modulating the levels of 8-OHdG, these inhibitors offer insights into the complex interplay between oxidative stress and DNA damage, shedding light on strategies for maintaining DNA integrity and mitigating the harmful effects of oxidative damage on cellular function.
SEE ALSO...
Items 1 to 10 of 12 total
Display:
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
O-(Carboxymethyl)hydroxylamine hemihydrochloride | 2921-14-4 | sc-207410B sc-207410 sc-207410A | 250 mg 1 g 10 g | $54.00 $105.00 $314.00 | ||
Inhibits glycosylase activity of DNA glycosylase enzymes, which are involved in the repair of DNA damage, potentially affecting 8-OHdG levels. | ||||||
N-Acetyl-L-cysteine | 616-91-1 | sc-202232 sc-202232A sc-202232C sc-202232B | 5 g 25 g 1 kg 100 g | $33.00 $73.00 $265.00 $112.00 | 34 | |
An antioxidant that scavenges reactive oxygen species, potentially reducing oxidative stress and limiting the formation of 8-OHdG. | ||||||
5,7-Dihydroxy-4-methylcoumarin | 2107-76-8 | sc-254863 | 1 g | $89.00 | 1 | |
A compound with potential radical scavenging properties that might help reduce the formation of reactive oxygen species and 8-OHdG. | ||||||
Mito-Q | 444890-41-9 | sc-507441 | 5 mg | $284.00 | ||
A mitochondria-targeted antioxidant that may reduce oxidative stress and mitochondrial DNA damage, potentially impacting 8-OHdG levels. | ||||||
Baicalein | 491-67-8 | sc-200494 sc-200494A sc-200494B sc-200494C | 10 mg 100 mg 500 mg 1 g | $31.00 $41.00 $159.00 $286.00 | 12 | |
A flavonoid with antioxidant properties that could inhibit oxidative DNA damage and reduce the formation of 8-OHdG. | ||||||
DL-α-Tocopherol | 10191-41-0 | sc-294383 sc-294383A sc-294383B sc-294383C | 5 g 25 g 100 g 500 g | $25.00 $51.00 $122.00 $320.00 | 3 | |
An antioxidant that may prevent lipid peroxidation and DNA damage, potentially affecting the generation of 8-OHdG. | ||||||
Tiron | 149-45-1 | sc-253699 sc-253699A | 10 g 25 g | $28.00 $40.00 | 11 | |
A superoxide scavenger that may reduce oxidative stress and reactive oxygen species, potentially limiting the formation of 8-OHdG. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
A polyphenol with antioxidant properties that might reduce oxidative DNA damage and decrease 8-OHdG levels. | ||||||
Melatonin | 73-31-4 | sc-207848 sc-207848A sc-207848B sc-207848C sc-207848D sc-207848E | 1 g 5 g 25 g 100 g 250 g 1 kg | $64.00 $72.00 $214.00 $683.00 $1173.00 $3504.00 | 16 | |
A hormone with antioxidant properties that could potentially scavenge free radicals and reduce oxidative DNA damage, including 8-OHdG. | ||||||
Rutin trihydrate | 250249-75-3 | sc-204897 sc-204897A sc-204897B | 5 g 50 g 100 g | $56.00 $71.00 $124.00 | 7 | |
A flavonoid with antioxidant effects that might prevent DNA damage and reduce the formation of 8-OHdG. | ||||||