8-OHdG Activators
Common 8-OHdG Activators include, but are not limited to Hydrogen Peroxide CAS 7722-84-1, Benzo[a]pyrene CAS 50-32-8, Iron CAS 7439-89-6, Arsenic(III) oxide CAS 1327-53-3 and Acrylamide CAS 79-06-1.
8-OHdG activators is a group of chemical compounds that have the capacity to interact with and influence the levels of 8-hydroxy-2'-deoxyguanosine (8-OHdG) in biological systems. 8-OHdG is a modified form of deoxyguanosine, one of the four basic building blocks of DNA. It is produced when DNA is exposed to oxidative stress, a condition characterized by an excess of reactive oxygen species (ROS) or free radicals. These ROS can damage DNA, leading to various mutations.
The activation of 8-OHdG, or its increase in cellular or tissue samples, is often used as a marker for oxidative DNA damage. It can be detected through various laboratory techniques, such as mass spectrometry and immunoassays. 8-OHdG activators are compounds that may influence the production or accumulation of 8-OHdG in biological systems. It's important to note that these activators are commonly used as research tools to investigate the role of oxidative DNA damage in various biological processes. Understanding how these activators affect 8-OHdG levels can provide valuable insights into the mechanisms of DNA damage and repair, which are fundamental to cellular health and the development of strategies to mitigate the impact of oxidative stress.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Hydrogen Peroxide | 7722-84-1 | sc-203336 sc-203336A sc-203336B | 100 ml 500 ml 3.8 L | $30.00 $60.00 $93.00 | 27 | |
A direct source of ROS that can cause DNA damage and increase 8-OHdG levels. | ||||||
Benzo[a]pyrene | 50-32-8 | sc-257130 | 1 g | $439.00 | 4 | |
A polycyclic aromatic hydrocarbon that can induce oxidative stress and increase 8-OHdG levels. | ||||||
Iron | 7439-89-6 | sc-215190 sc-215190A | 500 g 2 kg | $68.00 $176.00 | ||
Excess iron can catalyze the Fenton reaction, producing ROS and increasing 8-OHdG levels. | ||||||
Arsenic(III) oxide | 1327-53-3 | sc-210837 sc-210837A | 250 g 1 kg | $87.00 $224.00 | ||
Can induce oxidative stress and elevate 8-OHdG levels. | ||||||
Paraquat chloride | 1910-42-5 | sc-257968 | 250 mg | $149.00 | 7 | |
A herbicide that induces ROS production, leading to oxidative DNA damage and increased 8-OHdG. | ||||||
Acrylamide Solution, 40% | 79-06-1 | sc-3721 | 1 L | $98.00 | ||
Can induce oxidative stress, leading to increased 8-OHdG levels. | ||||||
Doxorubicin | 23214-92-8 | sc-280681 sc-280681A | 1 mg 5 mg | $173.00 $418.00 | 43 | |
An anticancer suggested compound that can induce ROS production, leading to oxidative DNA damage. | ||||||
Cisplatin | 15663-27-1 | sc-200896 sc-200896A | 100 mg 500 mg | $76.00 $216.00 | 101 | |
While primarily a DNA cross-linking agent, it can also induce oxidative stress and increase 8-OHdG levels. | ||||||
Rotenone | 83-79-4 | sc-203242 sc-203242A | 1 g 5 g | $89.00 $254.00 | 41 | |
An inhibitor of mitochondrial complex I, it can increase ROS production and 8-OHdG levels. | ||||||