Molecular structure of Tiron, CAS Number: 149-45-1
Tiron (CAS 149-45-1)
See product citations (11)
Alternate Names:
4,5-Dihydroxy-1,3-benzenedisulfonic acid disodium salt
Application:
Tiron is an indicator for complexometry
CAS Number:
149-45-1
Molecular Weight:
332.22
Molecular Formula:
C6H4O8S2•2Na
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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Tiron is a compound that is in analytical chemistry and biochemistry due to its chelating properties and ability to scavenge free radicals. It is frequently in studies focused on oxidative stress and the antioxidant capacity of various systems, where Tiron′s efficacy in capturing reactive oxygen species is of particular interest. Tiron is utilized in the examination of transition metal catalysis, as it can form stable complexes with metals, affecting their reactivity and solubility. In environmental chemistry, Tiron is applied to understand the mobilization and remediation of heavy metals in soil and water. It also serves as a model compound in the study of the photochemical behavior of organic substances under UV radiation due to its ability to absorb light and generate radicals.
Tiron (CAS 149-45-1) References
- Heme oxygenase-mediated vasodilation involves vascular smooth muscle cell hyperpolarization. | Naik, JS. and Walker, BR. 2003. Am J Physiol Heart Circ Physiol. 285: H220-8. PMID: 12637349
- Endothelial NO Synthase (eNOS) phosphorylation regulates coronary diameter during ischemia-reperfusion in association with oxidative stress. | Hoshino, S., et al. 2005. Free Radic Res. 39: 481-9. PMID: 16036323
- Hypertension increases contractile responses to hydrogen peroxide in resistance arteries through increased thromboxane A2, Ca2+, and superoxide anion levels. | García-Redondo, AB., et al. 2009. J Pharmacol Exp Ther. 328: 19-27. PMID: 18818375
- The late Na+ current (INa) inhibitor ranolazine attenuates effects of palmitoyl-L-carnitine to increase late INa and cause ventricular diastolic dysfunction. | Wu, Y., et al. 2009. J Pharmacol Exp Ther. 330: 550-7. PMID: 19403851
- Brain-derived neurotrophic factor in cigarette smoke-induced airway hyperreactivity. | Sathish, V., et al. 2013. Am J Respir Cell Mol Biol. 48: 431-8. PMID: 23258230
- Synthesis, characterization, and anticancer activity of ruthenium(II)-β-carboline complex. | Chen, Y., et al. 2013. Eur J Med Chem. 70: 120-9. PMID: 24141202
- Excess iodide induces an acute inhibition of the sodium/iodide symporter in thyroid male rat cells by increasing reactive oxygen species. | Arriagada, AA., et al. 2015. Endocrinology. 156: 1540-51. PMID: 25594695
- Antioxidant nitroxides protect hepatic cells from oxidative stress-induced cell death. | Shinto, S., et al. 2018. J Clin Biochem Nutr. 62: 132-138. PMID: 29610552
- Lipoic Acid and Progesterone Alone or in Combination Ameliorate Retinal Degeneration in an Experimental Model of Hereditary Retinal Degeneration. | Ramírez-Lamelas, DT., et al. 2018. Front Pharmacol. 9: 469. PMID: 29867476
- Copper bis-Dipyridoquinoxaline Is a Potent DNA Intercalator that Induces Superoxide-Mediated Cleavage via the Minor Groove. | Molphy, Z., et al. 2019. Molecules. 24: PMID: 31779066
- Hardness and Indentation Fracture Toughness of Slip Cast Alumina and Alumina-Zirconia Ceramics. | Žmak, I., et al. 2019. Materials (Basel). 13: PMID: 31888013
- The Role of the Reactive Species Involved in the Photocatalytic Degradation of HDPE Microplastics Using C,N-TiO2 Powders. | Vital-Grappin, AD., et al. 2021. Polymers (Basel). 13: PMID: 33805116
- Synthesis, structure and the Hirshfeld surface analysis of three novel metal-tiron coordination complexes. | Tiwari, RK., et al. 2021. RSC Adv. 11: 10767-10776. PMID: 35423596
- Caspase Inhibition Modulates Monocyte-Derived Macrophage Polarization in Damaged Tissues. | Solier, S., et al. 2023. Int J Mol Sci. 24: PMID: 36835566
- NADH oxidoreductase is a major source of superoxide anion in bovine coronary artery endothelium. | Mohazzab, KM., et al. 1994. Am J Physiol. 266: H2568-72. PMID: 8024019
Inhibitor of:
8-OHdG, ABCB7, PYROXD1, Romo1, and VAT1L.Activator of:
ACAD-9, cadherin-18, DUOX2, FRP1, ISCA1, Mel13, Mox1, NDUFA11, NDUFB7, OSGIN2, and UQCRC2.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Tiron, 10 g | sc-253699 | 10 g | $29.00 | |||
Tiron, 25 g | sc-253699A | 25 g | $41.00 |