4930444G20Rik Activators
Chemical activators of SEMP2L2B include a variety of compounds that influence the protein's activity through different biochemical pathways. Resveratrol, for example, can activate SEMP2L2B by enhancing the deacetylation process through SIRT1 activation, which facilitates the deSUMOylation of proteins by SEMP2L2B. Spermidine contributes to SEMP2L2B activation by inhibiting EP300, an acetyltransferase, thus promoting autophagy and potentially increasing the degradation of SUMOylated proteins. This may lead to a greater supply of substrates for SEMP2L2B. Anacardic Acid operates by inhibiting HAT activity, which can result in less acetylation and more SUMOylation of proteins, indirectly increasing the activity of SEMP2L2B by providing a larger pool of SUMOylated proteins to be processed. Oleuropein activates AMPK, which can encourage the SUMOylation process and, consequently, augment the activity of SEMP2L2B by increasing the availability of substrate proteins.
Additional chemical activators include Sulforaphane, which through Nrf2 activation, can modulate protein SUMOylation and thus support the activity of SEMP2L2B. Curcumin can activate SEMP2L2B by altering the SUMOylation status of proteins via effects on SUMO-specific proteases. Piperlongumine can raise intracellular ROS levels, which may affect SUMOylation pathways and result in the activation of SEMP2L2B. Compounds like Epigallocatechin Gallate, Quercetin, and Genistein can activate SEMP2L2B by interacting with various signaling pathways that influence protein SUMOylation. Epigallocatechin Gallate can modulate signaling pathways, while Quercetin activates PI3K/Akt signaling, and Genistein engages estrogen receptor signaling-all potentially leading to an increased SUMOylation of proteins and enhancing SEMP2L2B activity. Kaempferol and Withaferin A also play roles in the activation of SEMP2L2B; Kaempferol through its antioxidant properties, and Withaferin A by disrupting the cytoskeletal network, which can change the SUMOylation status of proteins and, in turn, activate SEMP2L2B.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Resveratrol activates sirtuin 1 (SIRT1), an enzyme that deacetylates proteins and can lead to the activation of SUMO/sentrin specific peptidase 2-like 2B (SEMP2L2B) by facilitating its deSUMOylation. | ||||||
Spermidine | 124-20-9 | sc-215900 sc-215900B sc-215900A | 1 g 25 g 5 g | $56.00 $595.00 $173.00 | ||
Spermidine can induce autophagy through inhibition of the acetyltransferase EP300, which may result in increased autophagic degradation of SUMOylated proteins, thus indirectly activating SEMP2L2B by increasing the availability of its substrates. | ||||||
Anacardic Acid | 16611-84-0 | sc-202463 sc-202463A | 5 mg 25 mg | $100.00 $200.00 | 13 | |
Anacardic Acid inhibits histone acetyltransferase (HAT) activity, which might lead to a decrease in the acetylation of proteins and an increase in SUMOylation, indirectly activating SEMP2L2B by providing more SUMOylated proteins to be processed. | ||||||
Oleuropein | 32619-42-4 | sc-286622 sc-286622A sc-286622B sc-286622C | 500 mg 1 g 10 g 100 g | $352.00 $520.00 $775.00 $6640.00 | 2 | |
Oleuropein has been shown to activate AMP-activated protein kinase (AMPK), which can promote the SUMOylation process, potentially leading to an increase in substrate proteins for SEMP2L2B, thus enhancing its activity. | ||||||
D,L-Sulforaphane | 4478-93-7 | sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D | 5 mg 10 mg 25 mg 1 g 10 g 250 mg | $150.00 $286.00 $479.00 $1299.00 $8299.00 $915.00 | 22 | |
Sulforaphane activates nuclear factor erythroid 2-related factor 2 (Nrf2), leading to the transcription of detoxifying enzymes. Nrf2 activation can also modulate protein SUMOylation, which may increase the activity of SEMP2L2B. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
Curcumin can activate SEMP2L2B by modulating the SUMOylation status of cellular proteins through its effect on SUMO-specific proteases, although the exact mechanism is not fully understood. | ||||||
Piperlongumine | 20069-09-4 | sc-364128 | 10 mg | $107.00 | ||
Piperlongumine increases the levels of reactive oxygen species (ROS) within cells. Elevated ROS can influence signaling pathways that involve SUMOylation, thereby activating SEMP2L2B by increasing its substrate availability. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
Epigallocatechin Gallate (EGCG) can activate SEMP2L2B by influencing pathways that enhance the SUMOylation of proteins, as EGCG has been shown to modulate several signaling pathways that can affect protein SUMOylation. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $108.00 $245.00 $918.00 $49.00 | 33 | |
Quercetin activates phosphatidylinositol 3-kinases (PI3K)/Akt signaling, which is involved in the regulation of protein SUMOylation. This activation can indirectly enhance the activity of SEMP2L2B. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $26.00 $92.00 $120.00 $310.00 $500.00 $908.00 $1821.00 | 46 | |
Genistein, by activating estrogen receptor signaling, can lead to altered SUMOylation patterns in cells, thus potentially increasing the functional activation of SEMP2L2B by providing more substrates for its enzymatic activity. | ||||||