17β-HSD14 Inhibitors
17β-HSD14 inhibitors are a distinctive class of compounds that do not directly target the enzyme's active site but modulate its activity by influencing the availability of substrates or cofactors required for its catalytic action. This modulation is achieved through various biochemical pathways and interactions with different cellular components.
Alizarin, for example, exerts its inhibitory effect by chelating zinc, a vital cofactor for 17β-HSD14, thus potentially altering the enzyme's conformation and function. Similarly, heavy metals like lead acetate and cadmium chloride disrupt enzyme activity by binding to thiol groups or replacing essential metal cofactors within the enzyme. Arsenic trioxide extends this approach by targeting sulfhydryl groups on proteins, which could inactivate 17β-HSD14.
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Items 1 to 10 of 11 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Finasteride | 98319-26-7 | sc-203954 | 50 mg | $105.00 | 3 | |
Finasteride is an inhibitor of steroid 5α-reductase, an enzyme that converts testosterone to dihydrotestosterone (DHT). By inhibiting this enzyme, finasteride indirectly decreases the availability of androgens that could modulate the activity of 17β-HSD14 in androgen-sensitive tissues, leading to diminished 17β-HSD14 function. | ||||||
Dutasteride | 164656-23-9 | sc-207600 | 10 mg | $167.00 | 2 | |
Dutasteride, like finasteride, suppresses the enzyme 5α-reductase. However, it targets both isozymes, Type I and Type II, resulting in a more extensive reduction of DHT levels. The consequential decrease in androgenic signaling can attenuate the activity of 17β-HSD14 indirectly, as androgens are substrates and modulators of its function. | ||||||
Ketoconazole | 65277-42-1 | sc-200496 sc-200496A | 50 mg 500 mg | $63.00 $265.00 | 21 | |
Ketoconazole is a broad-spectrum antifungal known to inhibit cytochrome P450 enzymes involved in steroid synthesis. By reducing steroid biosynthesis, ketoconazole can decrease substrates available for 17β-HSD14, leading to reduced activity of the enzyme. | ||||||
Aminoglutethimide | 125-84-8 | sc-207280 sc-207280A sc-207280B sc-207280C | 1 g 5 g 25 g 100 g | $42.00 $146.00 $541.00 $2060.00 | 2 | |
Aminoglutethimide inhibits the conversion of cholesterol to pregnenolone, the precursor of all steroids, thus reducing the substrate availability for 17β-HSD14 and consequently its activity. | ||||||
Letrozole | 112809-51-5 | sc-204791 sc-204791A | 25 mg 50 mg | $87.00 $147.00 | 5 | |
Letrozole is an aromatase inhibitor that blocks the conversion of androgens to estrogens. By decreasing estrogen synthesis, letrozole can indirectly lower 17β-HSD14 activity since 17β-HSD14 is involved in estrogen metabolism. | ||||||
Exemestane | 107868-30-4 | sc-203045 sc-203045A | 25 mg 100 mg | $134.00 $411.00 | ||
Exemestane, a steroidal aromatase inactivator, irreversibly binds to the aromatase enzyme, reducing estrogen synthesis. This reduction can indirectly affect 17β-HSD14 activity by altering the balance of estrogens, which are substrates for 17β-HSD14. | ||||||
Anastrozole | 120511-73-1 | sc-217647 | 10 mg | $92.00 | 1 | |
Anastrozole is an aromatase inhibitor that prevents the conversion of androgens to estrogens, influencing the substrate availability for 17β-HSD14 and thus its enzymatic activity. | ||||||
Mifepristone | 84371-65-3 | sc-203134 | 100 mg | $61.00 | 17 | |
Mifepristone acts as a glucocorticoid and progesterone receptor antagonist. By antagonizing progesterone, it may decrease the substrates available for 17β-HSD14, which is involved in the interconversion of 20-dihydro derivatives of progesterone. | ||||||
Trilostane | 13647-35-3 | sc-208469 sc-208469A | 10 mg 100 mg | $228.00 $1217.00 | 2 | |
Trilostane is an inhibitor of 3β-hydroxysteroid dehydrogenase, which is involved in the biosynthesis of all steroid hormones. By inhibiting upstream steroidogenesis, it indirectly reduces the availability of substrates for 17β-HSD14. | ||||||
Abiraterone | 154229-19-3 | sc-460288 | 10 mg | $276.00 | ||
Abiraterone inhibits cytochrome P450 17A1 (CYP17A1), which is essential for androgen biosynthesis. By lowering androgen levels, abiraterone indirectly affects 17β-HSD14 activity by decreasing the levels of its substrates. | ||||||