Letrozole CAS: 112809-51-5
MF: C17H11N5
MW: 285.30
A CYP19 (aromatase) inhibitor.

Letrozole (CAS 112809-51-5)

Letrozole | CAS 112809-51-5 is rated 5.0 out of 5 by 1.
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Alternate Names: 4,4′-(1H-1,2,4-Triazol-1-ylmethylene)bisbenzonitrile
Application: Letrozole is a CYP19 (aromatase) inhibitor
CAS Number: 112809-51-5
Purity: >98%
Molecular Weight: 285.30
Molecular Formula: C17H11N5
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).

Letrozole acts as a nonsteroidal CYP19 (aromatase) inhibitor. It is also known to inhibit estradiol production in vitro in hamster ovarian tissue that is LH-stimulated. Letrozole has not been shown to have a significant effect on progesterone production up to 350 M. Letrazole has been shown to inhibit aldosterone production in vitro in rat adrenal tissue stimulated by ACTH. No significant effect has been seen on corticosterone production at 350 M. Letrozole has no effect on corticosterone or aldoterone levels in vivo in ACTH-treated rats.


References

Ingle JN. Oncology (Huntingt). 15:28-34 (2001). Bhatnagar AS, Hausler A, Schieweck K et al. J Steroid Biochem Mol Biol. 37:1021-7 (1990). Brodie AM. J Steroid Biochem Mol Biol. 49:281-7 (1994).

Appearance :
Crystalline powder
Physical State :
Solid
Solubility :
Soluble in water (<1 mg/ml at 25° C), DMSO (57 mg/ml at 25° C), ethanol (<5 mg/ml, partially ), chloroform, and methanol.
Storage :
Store at room temperature
Melting Point :
183-185° C
Boiling Point :
~563.5° C at 760 mmHg (Predicted)
Density :
~1.2 g/cm3 (Predicted)
Refractive Index :
n20D 1.67 (Predicted)
IC50 :
CYP19: IC50 = 0.07 nM ( MCF-7Ca); CYP19: IC50 = 0.07 nM (JEG-3 human choriocarcinoma cells); CYP19: IC50 = 0.14 nM (Dex-treated fibroblasts); CYP19: IC50 = 0.8 nM (particulate fractions of human breast cancer); CYP19: IC50 = 1.4 nM (CHO cells)
Ki Data :
CYP19: Ki= 0.02 nM (human)
pK Values :
pKb: 1.52 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
DI4957000
PubChem CID :
3902
Merck Index :
14: 5450
MDL Number :
MFCD00866241
Beilstein Registry :
6813913
SMILES :
C1=CC(=CC=C1C#N)C(C2=CC=C(C=C2)C#N)N3C=NC=N3

Download SDS (MSDS)

Certificate of Analysis

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Letrozole (CAS 112809-51-5)  Product Citations

See how others have used Letrozole (CAS 112809-51-5). Click on the entry to view the PubMed entry .

Citations 1 to 3 of 3 total

PMID: # 28949811  Quinney, SK. et al. 2017. Fetal Pediatr Pathol. 36: 400-411.

PMID: # 26713732  Ziniel, PD. et al. 2015. PLoS Negl Trop Dis. 9: e0004279.

PMID: # 21176111  Aversa, A. et al. 2011. The journal of sexual medicine. 8: 696-704.

Citations 1 to 3 of 3 total
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Rated 5 out of 5 by from Kauffman Kauffman, AS. et al. (PubMed 26203175) reported that a novel Letrozole model recapitulates both the reproductive and metabolic phenotypes of polycystic ovary syndrome in female mice. -SCBT Publication Review
Date published: 2015-04-23
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