Letrozole acts as a nonsteroidal CYP19 (aromatase) inhibitor. It is also known to inhibit estradiol production in vitro in hamster ovarian tissue that is LH-stimulated. Letrozole has not been shown to have a significant effect on progesterone production up to 350 M. Letrazole has been shown to inhibit aldosterone production in vitro in rat adrenal tissue stimulated by ACTH. No significant effect has been seen on corticosterone production at 350 M. Letrozole has no effect on corticosterone or aldoterone levels in vivo in ACTH-treated rats.
Ingle JN. Oncology (Huntingt). 15:28-34 (2001). Bhatnagar AS, Hausler A, Schieweck K et al. J Steroid Biochem Mol Biol. 37:1021-7 (1990). Brodie AM. J Steroid Biochem Mol Biol. 49:281-7 (1994).
Soluble in water (<1 mg/ml at 25° C), DMSO (57 mg/ml at 25° C), ethanol (<5 mg/ml, partially ), chloroform, and methanol.
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KauffmanKauffman, AS. et al. (PubMed 26203175) reported that a novel Letrozole model recapitulates both the reproductive and metabolic phenotypes of polycystic ovary syndrome in female mice. -SCBT Publication Review
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