Anastrozole CAS: 120511-73-1
MF: C17H19N5
MW: 293.37
A CYP19 (aromatase) inhibitor.

Anastrozole (CAS 120511-73-1)

Anastrozole | CAS 120511-73-1 is rated 5.0 out of 5 by 1.
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Alternate Names: α1,α1,α3,α3-Tetramethyl-5-(1H-1,2,4-triazol-1-ylmethyl)-1,3-benzenediacetonitrile; 2-[3-(2-Cyano-2-propyl)-5-(1,2,4-triazol-1-ylmethyl)phenyl]-2-methylpropiononitrile; Anastrazole; Anastrol; Arimidex; ICI-D 1033; ZD 1033
Application: Anastrozole is a CYP19 (aromatase) inhibitor
CAS Number: 120511-73-1
Purity: ≥99%
Molecular Weight: 293.37
Molecular Formula: C17H19N5
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).

Anastrozole is known to inhibit the CYP19 enzyme (aromatase, IC50 = 15 nM) that converts androgens to estrogens. Anastrozole has been seen to reversibly bind to the CYP19 enzyme through competitive inhibition.


References

Plourde, P.V., et al.: Breast Cancer Res. Treat., 30, 103 (1994), Buzdar, A.U., et al.: Cancer, 79, 730 (1997)

Physical State :
Solid
Solubility :
Soluble in chloroform, methanol, ethanol (59 mg/ml at 25° C), DMSO (59 mg/ml at 25° C), and DMF (~14 mg/ml).
Storage :
Store at -20° C
Melting Point :
81-82° C
Boiling Point :
~469.7° C at 760 mmHg (Predicted)
Density :
~1.1 g/cm3 (Predicted)
Refractive Index :
n20D 1.58 (Predicted)
IC50 :
CYP19: IC50 = 1.5 nM (human)
pK Values :
pKb: 2.62 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
RTECS :
CZ1465000
PubChem CID :
2187
MDL Number :
MFCD00866298
Beilstein Registry :
8005958
SMILES :
CC(C)(C#N)C1=CC(=CC(CN2C=NC=N2)=C1)C(C)(C)C#N

Download SDS (MSDS)

Certificate of Analysis

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Citations 1 to 1 of 1 total

PMID: # 26713732  Ziniel, PD. et al. 2015. PLoS Negl Trop Dis. 9: e0004279.

Citations 1 to 1 of 1 total
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Rated 5 out of 5 by from Relevant assays for usage as analytical standards Relevant assays for usage as analytical standards.
Date published: 2015-06-08
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