Molecular structure of Exemestane, CAS Number: 107868-30-4
Exemestane (CAS 107868-30-4)
Alternate Names:
6-Methyleneandrosta-1,4-diene-3,17-dione
Application:
Exemestane is a CYP19 (aromatase) inhibitor
CAS Number:
107868-30-4
Molecular Weight:
296.40
Molecular Formula:
C20H24O2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Exemestane is a compound extensively studied in the field of enzyme inhibition, specifically focusing on the aromatase enzyme. Researchers are interested in exemestane for its ability to bind to the aromatase enzyme′s active site, thereby inhibiting its action. This mechanism is explored to understand the broader implications of enzyme inhibition in various biochemical pathways. In the field of biochemistry, exemestane is also used as a tool to study steroid biosynthesis and the role of aromatase in the conversion of androgens to estrogens. Additionally, exemestane is of interest in the development of assays for measuring aromatase activity in various tissues and in vitro systems. The compound′s effects on lipid metabolism are another avenue of research, as exemestane may influence lipid biosynthesis pathways.
Exemestane (CAS 107868-30-4) References
- Exemestane-induced corneal epithelial changes. | Papathanassiou, M., et al. 2010. Cutan Ocul Toxicol. 29: 209-11. PMID: 20470238
- Exemestane for primary prevention of breast cancer in postmenopausal women. | Zhang, Y., et al. 2012. Am J Health Syst Pharm. 69: 1384-8. PMID: 22855103
- Uptake of exemestane chemoprevention in postmenopausal women at increased risk for breast cancer. | Aktas, B., et al. 2016. Eur J Cancer Prev. 25: 3-8. PMID: 25642790
- Triggering of Suicidal Erythrocyte Death by Exemestane. | Al Mamun Bhuyan, A., et al. 2017. Cell Physiol Biochem. 42: 1-12. PMID: 28535537
- Exemestane loaded alginate nanoparticles for cancer treatment: Formulation and in vitro evaluation. | Jayapal, JJ. and Dhanaraj, S. 2017. Int J Biol Macromol. 105: 416-421. PMID: 28711612
- Effect of Aromatase Inhibition (Exemestane) on Urine Concentration of Osteoprotegerin in Healthy Postmenopausal Women. | Garcia, AP., et al. 2020. J Clin Pharmacol. 60: 209-217. PMID: 31535401
- Preclinical evaluation of exemestane as a novel chemotherapy for gastric cancer. | Yang, JC., et al. 2019. J Cell Mol Med. 23: 7417-7426. PMID: 31557413
- Methylome Variation Predicts Exemestane Resistance in Advanced ER+ Breast Cancer. | Liu, XR., et al. 2020. Technol Cancer Res Treat. 19: 1533033819896331. PMID: 32129154
- A case of exemestane induced pseudocellulitis. | Xue Ting, O., et al. 2020. Dermatol Ther. 33: e13428. PMID: 32301203
- Exemestane induced cholestatic liver injury - A case report. | Fritzsche, D., et al. 2021. J Oncol Pharm Pract. 27: 1029-1032. PMID: 32951520
- Thermoresponsive liquid crystalline formulation of Exemestane: Design and structural characterization. | Shah, V., et al. 2021. Colloids Surf B Biointerfaces. 202: 111683. PMID: 33721804
- Sapanisertib Plus Exemestane or Fulvestrant in Women with Hormone Receptor-Positive/HER2-Negative Advanced or Metastatic Breast Cancer. | Lim, B., et al. 2021. Clin Cancer Res. 27: 3329-3338. PMID: 33820779
- Insights on the interaction mechanism of exemestane to three digestive enzymes by multi-spectroscopy and molecular docking. | Huang, Y., et al. 2021. Int J Biol Macromol. 187: 54-65. PMID: 34274402
- A simple UPLC-MS/MS assay with a core-shell column for the determination of exemestane in human plasma for clinical application. | Ishii, T., et al. 2022. Eur J Mass Spectrom (Chichester). 28: 94-103. PMID: 36128912
- Effects of tamoxifen and exemestane on cognitive function in postmenopausal patients with breast cancer. | Lee Meeuw Kjoe, PR., et al. 2023. JNCI Cancer Spectr. 7: PMID: 37004168
Inhibitor of:
11β-HSD2, 17-β Estradiol, 17-β Estradiol 6, 17β-HSD11, 17β-HSD14, 17β-HSD2, 17β-HSD3, 17β-HSD6, 17β-HSD7, 3β-HSD3, 3β-HSD4, 3β-HSD5, Abp ε, AKR1D1, AV320801, C4orf30, Choriogonadotropin Holo c2, Choriogonadotropin Holo c3, CYP19, CYP26, Cyp3a41b, EEIG1, EG434676, EG545948, EG639025, ER, ER alpha, Estriol, Fdx1, FSHα, GCDFP-15, Gm694, Gonadotropin α, GREB1, Gros1, KLHL38, LDLRAD1, LOC100039517, LRP16, mPRε, NOBOX, Olr707, Olr727, Plfr, Rhox2, SAF-B2, StARD5, TEX30, TRIM47, TSARG6, Vmn2r23, ZP1, and ZP2.Activator of:
17β-HSD, 17β-HSD14, and SHBG.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Exemestane, 25 mg | sc-203045 | 25 mg | $134.00 | |||
Exemestane, 100 mg | sc-203045A | 100 mg | $411.00 |