0610037D15Rik Activators
RAI1 Activators encompass a diverse set of chemical compounds that indirectly amplify the functional activity of RAI1 through distinct signaling pathways and cellular processes. Phorbol 12-myristate 13-acetate (PMA) and Forskolin work by activating PKC and increasing cAMP levels respectively, both of which can lead to the phosphorylation and subsequent enhancement of RAI1's nuclear functions. In a similar vein, Ionomycin raises intracellular calcium levels, potentially activating kinases that can phosphorylate and thus enhance RAI1's activity in gene regulation. Epigallocatechin gallate and Lithium chloride contribute to RAI1 activation by inhibiting protein kinases that may act as negative regulators, while Spermidine promotes autophagy which could indirectly augment RAI1's efficacy by modulating the turnover of interacting proteins.
These mechanisms collectively suggest a multi-faceted approach to enhancing RAI1's role within the cell. 5-Azacytidine and Sodium butyrate, by inhibiting DNA methyltransferases and histone deacetylases respectively, lead to a more transcriptionally active chromatin state, which could enhance the ability of RAI1 to regulate gene expression effectively. Similarly, Trichostatin A, by preventing histone deacetylation, and Retinoic acid, through activation of retinoic acid receptors, may both improve the transcriptional regulatory functions of RAI1. Oleic acid, by altering membrane dynamics, might impact signaling pathways that modulate RAI1 activity. Curcumin, by its broad-spectrum modulation of signaling pathways, including those affecting transcription factors, could enhance the regulatory capacity of RAI1. These activators, through their targeted biochemical actions, facilitate the potentiation of RAI1's role in cellular processes without directly increasing its expression or acting through general pathways.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
PMA activates protein kinase C (PKC), which can lead to the phosphorylation of RAI1, enhancing its activity within the nucleus. PKC-mediated phosphorylation often results in changes in protein function, localization, and protein-protein interactions. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $76.00 $265.00 | 80 | |
Ionomycin is a calcium ionophore that raises intracellular calcium levels, thereby activating calcium-dependent kinases that could phosphorylate RAI1, potentially enhancing its activity in the regulation of gene expression. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
5-Azacytidine, a DNA methyltransferase inhibitor, can lead to decreased methylation of DNA, which might indirectly enhance RAI1's role in chromatin remodeling, as hypomethylated DNA is typically more transcriptionally active. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
Trichostatin A is an inhibitor of histone deacetylases (HDACs). By preventing deacetylation, it may lead to a more open chromatin structure, potentially enhancing the ability of RAI1 to regulate gene expression. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
Retinoic acid activates retinoic acid receptors (RARs) which can interact with RAI1, potentially enhancing its transcriptional regulatory functions due to the modification of chromatin structure and recruitment of coactivators. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
Epigallocatechin gallate is known to inhibit several protein kinases. By inhibiting kinases that may serve as negative regulators of RAI1, its activity in gene regulation could be indirectly enhanced. | ||||||
Spermidine | 124-20-9 | sc-215900 sc-215900B sc-215900A | 1 g 25 g 5 g | $56.00 $595.00 $173.00 | ||
Spermidine can induce autophagy and may enhance RAI1 activity by modulating the turnover of proteins that interact with or regulate RAI1, thus indirectly increasing its functional capacity in the cell. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Lithium chloride inhibits GSK-3β, a kinase that can phosphorylate transcription factors. Inhibition of GSK-3β may lead to enhanced activity of RAI1 by stabilizing proteins that interact with or positively regulate RAI1's function. | ||||||
Oleic Acid | 112-80-1 | sc-200797C sc-200797 sc-200797A sc-200797B | 1 g 10 g 100 g 250 g | $36.00 $102.00 $569.00 $1173.00 | 10 | |
Oleic acid can alter membrane lipid composition and fluidity, potentially affecting the localization and function of membrane-associated proteins that could modulate RAI1 activity indirectly by affecting signal transduction pathways. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
Curcumin can modulate various signaling pathways, including those that affect transcription factors. By influencing these pathways, curcumin may indirectly enhance RAI1's activity by affecting the transcriptional regulation of genes RAI1 is involved with. | ||||||