0610037D15Rik Inhibitors
Chemical inhibitors of protein 0610037D15Rik serve as targeted agents to impede its function through various molecular pathways. Staurosporine, known for its wide-ranging kinase inhibition capabilities, can obstruct numerous kinases that are responsible for the phosphorylation and subsequent activation of 0610037D15Rik. Similarly, Bisindolylmaleimide I, by selectively inhibiting protein kinase C (PKC), can prevent the activation of 0610037D15Rik if PKC is implicated in its phosphorylation. Other inhibitors like LY294002 and Wortmannin zero in on phosphoinositide 3-kinases (PI3K), blocking the PI3K pathway and potentially halting the activation signals that lead to the functional state of 0610037D15Rik. These inhibitors collectively function by disrupting the upstream signaling events that are crucial for the activation of 0610037D15Rik.
In addition to these, PD98059 and U0126, both MEK inhibitors, can impede the MAPK/ERK pathway, a key signaling route that may be involved in the phosphorylation of 0610037D15Rik. By preventing the activation of ERK, these inhibitors can impede the downstream phosphorylation events. SP600125 and SB203580 target the stress-activated MAPK pathways, with SP600125 inhibiting the c-Jun N-terminal kinase (JNK) and SB203580 targeting the p38 MAP kinase. The inhibition of these kinases can lead to a decrease in 0610037D15Rik activity if JNK or p38 MAPK are involved in its activation. NF449 inhibits the Gs-alpha subunit of G-proteins, potentially reducing the production of cyclic AMP, a molecule that can be essential for the activation of various proteins, including 0610037D15Rik. Go6983 and Ro-31-8220, also PKC inhibitors, can further ensure the blockade of PKC-mediated phosphorylation of 0610037D15Rik. Lastly, Rapamycin, an mTOR inhibitor, can suppress the mTOR signaling pathway, which may also play a role in the activation of 0610037D15Rik, thus preventing its functional activity within the cell.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $150.00 $388.00 | 113 | |
Staurosporine is a non-selective kinase inhibitor which can inhibit a broad spectrum of kinases that might phosphorylate 0610037D15Rik, leading to its functional inhibition by preventing its activation. | ||||||
Bisindolylmaleimide I (GF 109203X) | 133052-90-1 | sc-24003A sc-24003 | 1 mg 5 mg | $103.00 $237.00 | 36 | |
Bisindolylmaleimide I is a specific protein kinase C inhibitor. By inhibiting PKC, it can prevent the phosphorylation of 0610037D15Rik if PKC is directly responsible for the activation of 0610037D15Rik. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 is a specific inhibitor of PI3K. It can impede the PI3K pathway, which might be responsible for activation signals leading to the functional state of 0610037D15Rik, thereby inhibiting its function. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
PD98059 is a MEK inhibitor which can inhibit the MAPK/ERK pathway. By preventing ERK's activation, it could inhibit downstream proteins like 0610037D15Rik by preventing their phosphorylation and subsequent activation. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $63.00 $241.00 | 136 | |
U0126 is another MEK inhibitor which can prevent the activation of the MAPK/ERK pathway. It could inhibit the phosphorylation of 0610037D15Rik, assuming that the ERK pathway is involved in the regulation or activation of 0610037D15Rik. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
SP600125 is an inhibitor of c-Jun N-terminal kinase (JNK), part of the stress-activated MAPK pathways. If JNK is involved in the activation of 0610037D15Rik, inhibiting JNK can lead to functional inhibition of 0610037D15Rik. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
SB203580 is a p38 MAP kinase inhibitor which can inhibit the p38 MAPK pathway. If 0610037D15Rik is regulated or activated by p38 MAPK, inhibition of this kinase can result in functional inhibition of 0610037D15Rik. | ||||||
NF449 | 627034-85-9 | sc-478179 sc-478179A sc-478179B | 10 mg 25 mg 100 mg | $199.00 $460.00 $1479.00 | 1 | |
NF449 is a potent and selective inhibitor of the Gs-alpha subunit of G-proteins. By preventing G-protein-mediated signal transduction, it could inhibit the production of cyclic AMP, which may be necessary for the activation of downstream proteins such as 0610037D15Rik, thus inhibiting its function. | ||||||
Gö 6983 | 133053-19-7 | sc-203432 sc-203432A sc-203432B | 1 mg 5 mg 10 mg | $103.00 $293.00 $465.00 | 15 | |
Go6983 is a protein kinase C inhibitor. It can inhibit multiple isoforms of PKC, which could be responsible for the phosphorylation and activation of 0610037D15Rik, resulting in its functional inhibition. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
Wortmannin is a PI3K inhibitor. By inhibiting PI3K, it could prevent the production of PIP3 and subsequent activation of AKT, which might be responsible for the phosphorylation and functional activation of 0610037D15Rik, thus inhibiting its function. | ||||||