SB 203580 CAS: 152121-47-6
MF: C21H16FN3OS
MW: 377.43

SB 203580 (CAS 152121-47-6)

  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getAggregateRating, 92ms
  • REVIEWS, PRODUCT
  • bvseo-msg: The resource to the URL or file is currently unavailable.;
SB 203580 is rated 5.0 out of 5 by 5.
loading
5
5
4
0
3
0
2
0
1
0
备用名: SB 203580 is also known as RWJ 64809.
应用; SB 203580 is a pyridinyl imidazole and specific inhibitor that suppresses p38 mediated activation of MK2.
CAS号码: 152121-47-6
纯度: ≥98%
分子量: 377.43
分子式: C21H16FN3OS
仅供科研使用。不可用于诊断或治疗。
* 参考分析证明 大量特定数据 (包括水 含量).
loading

SB 203580 is a pyridinyl imidazole which suppresses the p38 mediated activation of MAPKAP kinase-2 (MAPKAP K2 or MK2), yet does not disrupt JNK activity. Mitogen-activated protein kinases (MAPK) are a group of serine and threonine-specific kinases sensitive to cellular stress, heat shock and proinflammatory cytokines. p38 MAPK is critical for normal immune and inflammatory responses as it regulates the expression of many cytokines, transcription factors, and cell surface receptors. SB 203580 inhibits the phosphorylation of heat shock protein 27 (HSP 27). SB 203580 has been shown to induce the activation of Raf-1. SB 203580 has also been shown to prevent the activation of PKB/Akt by inhibiting phosphoinositide-dependent protein kinase 1 (PDK1). SB 203580 is a useful tool to assess the physiological roles of p38, and for deriving and maintaining embryonic stem cells.


参考文献

1. Cuenda, A., et al. 1995. FEBS Lett. 364: 229-233. PMID: 7750577

2. Saklatvala, J., et al. 1996. J. Biol. Chem. 271: 6586-6589. PMID: 8636072

3. Young, P.R., et al. 1997. J. Biol. Chem. 272: 12116-12121. PMID: 9115281

4. Clerk, A. and Sugden, P.H. 1998. FEBS Lett. 426: 93-96. PMID: 9598985

5. Hashimoto, S., et al. 1999. Biochem. Biophys. Res. Commun. 258: 443-447. PMID: 10329406

6. Kalmes, A., et al. 1999. FEBS Lett. 444: 71-74. PMID: 10037150

7. Hall-Jackson, C.A., et al. 1999. Oncogene. 18: 2047-2054. PMID: 10321729

8. Qi, X., et al. 2004. Proc. Natl. Acad. Sci. U.S.A. 101: 6027-6032. PMID: 15075392

9. Cao, W., et al. 2006. Am. J. Physiol. Gastrointest. Liver Physiol. 291: G672-G680. PMID: 16645161

物理状态 :
Solid
溶解度 :
Soluble in DMSO (50 mg/ml), aqueous buffers (Sparingly soluble), methanol, acetone, ethanol (~0.2 mg/ml), and 1:9 solution of DMF:PBS(PH 7.2) (~0.5 mg/ml).
保存 :
Store at -20° C
熔点 :
280.73° C (Predicted)
沸点 :
~615.6° C at 760 mmHg (Predicted)
密度 :
~1.4 g/cm3 (Predicted)
折射率 :
n20D 1.71
IC50 :
p38 MAP kinase : IC50 = 34 nM; IL-1 and TNF-α : IC50 = 50-100 nM (LPS-stimulated human monocytes and the human monocyte cell line THP-1); SAPK2a/p38: EC5050 = 50 nM; SAPK2b/p38β2: IC50 = 500 nM
Ki 数据 :
MAP kinase p38 alpha: Ki= 18 nM (Homo sapiens); c-Jun N-terminal kinase 3: Ki= 90 nM (Homo sapiens)
pK值 :
pKb: 9.09
仅供科研使用。不可用于诊断或治疗。
德国水公害等级 :
3
RTECS :
UT3967600
PubChem CID :
MDL 号码 :
MFCD00922198
SMILES :
CS(=O)C1=CC=C(C=C1)C2=NC(=C(N2)C3=CC=NC=C3)C4=CC=C(C=C4)F

下载SDS

分析证明书

在PDF文件上阅读,打印和批注,Adobe阅读器是必须的

SB 203580 (CAS 152121-47-6)  产品相关文献索引

看其他用户如何应用SB 203580 (CAS 152121-47-6).点击进入浏览PubMed条目 .

引用1 - 10259

PMID: # 33921748  Shi, Q.|Hu, B.|Yang, C.|Zhao, L.|Wu, J.|Qi, N.| et al. 2021. Int J Mol Sci. 22:

PMID: # 34246054  Zhang, M.|Liu, J.|Gao, R.|Hu, Y.|Lu, L.|Liu, C.|Ai, L.|Pan, J.|Tian, L.|Fan, J.| et al. 2021. Cytokine. 146: 155630.

PMID: # 33990641  Hirata, Y.|Takahashi, M.|Yamada, Y.|Matsui, R.|Inoue, A.|Ashida, R.|Noguchi, T.|Matsuzawa, A.| et al. 2021. Sci Rep. 11: 10350.

PMID: # 34070682  Mezzasoma, L.|Talesa, VN.|Costanzi, E.|Bellezza, I.| et al. 2021. Biomolecules. 11:

PMID: # 34165247  Ho, HY.|Chen, PJ.|Lo, YS.|Lin, CC.|Chuang, YC.|Hsieh, MJ.|Chen, MK.| et al. 2021. Environ Toxicol.

PMID: # 33578238  Ho, HY.|Lin, CC.|Chuang, YC.|Lo, YS.|Hsieh, MJ.|Chen, MK.| et al. 2021. Biomed Pharmacother. 137: 111362.

PMID: # 34065077  Bharath Kumar, V.|Lin, JT.|Mahalakshmi, B.|Chuang, YC.|Ho, HY.|Lin, CC.|Lo, YS.|Hsieh, MJ.|Chen, MK.| et al. 2021. Int J Mol Sci. 22:

PMID: # 33463904  Venter, C.|Myburgh, KH.|Niesler, CU.| et al. 2021. Physiol Rep. 9: e14704.

PMID: # 32999166  Hirata, Y.|Nada, Y.|Yamada, Y.|Toyama, T.|Fukunaga, K.|Hwang, GW.|Noguchi, T.|Matsuzawa, A.| et al. 2020. Biol Pharm Bull. 43: 1562-1569.

PMID: # 33101201  Kumar, VB.|Lin, SH.|Mahalakshmi, B.|Lo, YS.|Lin, CC.|Chuang, YC.|Hsieh, MJ.|Chen, MK.| et al. 2020. Front Endocrinol (Lausanne). 11: 568436.

引用1 - 10259
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getContent, 113ms
  • QUESTIONS, PRODUCT
  • bvseo-msg: The resource to the URL or file is currently unavailable.;
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getReviews, 7ms
  • REVIEWS, PRODUCT
  • bvseo-msg: The resource to the URL or file is currently unavailable.;