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LY-165,163 is a selective 5-HT1A and 5-HT1D serotonin receptor antagonists.
Cohen, M.L., et al., In vitro receptor specificity of the 5-HT1A selective phenylpiperazine, LY-165,163. Life Sci. 39, 2441, (1986) Fuller, R.W., et al., Central serotonin agonist actions of LY165,163 l-(m-trifluoromethylphenyl)-4-(p-aminophenethyl) piperazine in rats. J. Pharmacol. Exp. Ther. 239, 454, (1986) Hutson, P.H., et al., Neurochemical and behavioral evidence for an agonist action of 1-[2-(4-aminophenyl) ethyl]-4-(3-trifluoromethyl-phenyl) piperazine (LY-165,163) at central 5-HT receptors. Eur. J. Pharmacol. 138, 215, (1987) Kalkman, H.O., Neumann, V., Evidence for a 5-HT1D receptor-mediated hypothermic effect of the alpha 1-adrenoceptor agonist SDZ NVI-085 in guinea-pigs. Eur. J. Pharmacol. 285, 313, (1995)
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