Molecular structure of Tropicamide, CAS Number: 1508-75-4
Tropicamide (CAS 1508-75-4)
See product citations (3)
Alternate Names:
N-Ethyl-2-phenyl-N-(4-pyridylmethyl hydracrylamide; Ro 1-7683
Application:
Tropicamide is a mAChR M4 antagonist
CAS Number:
1508-75-4
Purity:
≥99%
Molecular Weight:
284.40
Molecular Formula:
C17H20N2O2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
QUICK LINKS
Ordering Information
Product Citations
Description
Technical Information
Safety Information
SDS & Certificate of Analysis
Tropicamide is a synthetic compound known for its role as a mydriatic agent, used to study pupil dilation. It functions by blocking muscarinic acetylcholine receptors, which leads to the relaxation of certain involuntary muscles. This action is useful in applications that require temporary changes in muscle tone for procedural purposes. Tropicamide′s rapid onset and short duration of action make it well-suited for applications where temporary effects are desired without prolonged impacts. Its primary mechanism involves the inhibition of receptors that typically control involuntary muscle movements.
Tropicamide (CAS 1508-75-4) References
- Subtypes of muscarinic receptors regulating gallbladder cholinergic contractions. | Parkman, HP., et al. 1999. Am J Physiol. 276: G1243-50. PMID: 10330016
- Spontaneously hypertensive rats cholinergic hyper-responsiveness: central and peripheral pharmacological mechanisms. | Lazartigues, E., et al. 1999. Br J Pharmacol. 127: 1657-65. PMID: 10455323
- The effects of topical tropicamide and systemic medetomidine, followed by atipamezole reversal, on pupil size and intraocular pressure in normal dogs. | Wallin-Håkanson, N. and Wallin-Håkanson, B. 2001. Vet Ophthalmol. 4: 3-6. PMID: 11397312
- Cycloplegic effect of 0.5% tropicamide and 0.5% phenylephrine mixed eye drops: objective assessment in Japanese schoolchildren with myopia. | Hamasaki, I., et al. 2007. Jpn J Ophthalmol. 51: 111-5. PMID: 17401620
- The muscarinic receptor antagonist tropicamide suppresses tremulous jaw movements in a rodent model of parkinsonian tremor: possible role of M4 receptors. | Betz, AJ., et al. 2007. Psychopharmacology (Berl). 194: 347-59. PMID: 17594079
- Variation in intraocular pressure following application of tropicamide in three different dog breeds. | Taylor, NR., et al. 2007. Vet Ophthalmol. 10 Suppl 1: 8-11. PMID: 17973829
- Muscarinic receptor subtypes in the alimentary tract. | Tobin, G., et al. 2009. J Physiol Pharmacol. 60: 3-21. PMID: 19439804
- Anti-inflammatory effect of the spirocyclopiperazinium compound LXM-10 in mice and rats. | Xiong, Y., et al. 2010. Eur J Pharmacol. 626: 290-6. PMID: 19836382
- [The distribution of tropicamide in the body of warm-blooded animals after its intragastric administration]. | Shormanov, VK., et al. 2016. Sud Med Ekspert. 59: 27-34. PMID: 27070036
- Ocular tolerance in rabbits after intracameral administration of a fixed combination of tropicamide, phenylephrine, and lidocaine with and without rinsing. | Nuijts, RMMA., et al. 2017. J Cataract Refract Surg. 43: 673-679. PMID: 28602331
- An UPLC-MS/MS Method for Simultaneous Determination of Tropicamide and Phenylephrine in Rabbit Ocular Tissues and Plasma. | Zhao, X., et al. 2020. J Ocul Pharmacol Ther. 36: 282-289. PMID: 32320311
- Effect of tropicamide on ocular blood flow in the rabbit. | Delgado, D., et al. 1982. Am J Optom Physiol Opt. 59: 410-2. PMID: 7102799
- The effects of tropicamide on mydriasis in young rats exhibiting a natural deficit in passive-avoidance responding. | Smith, RD., et al. 1996. Life Sci. 59: 753-60. PMID: 8761028
Inhibitor of:
AChRα1, D730048I06Rik, D930020B18Rik, E3BP, GALR2, mAChR M3, mAChR M4, Olfr381, and SMGC.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Tropicamide, 100 mg | sc-202371 | 100 mg | $32.00 |