Amisulpride CAS: 71675-85-9
MF: C17H27N3O4S
MW: 369.48
Amisulpride is a selective D2DR and D3DR inhibitor.

Amisulpride (CAS 71675-85-9)

Amisulpride | CAS 71675-85-9 is rated 5.0 out of 5 by 1.
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Alternate Names: 4-Amino-N-[(1-ethyl-2-pyrrolidinyl)methyl]-5-(ethylsulf onyl)-2-benzamide DAN 2163
Application: Amisulpride is a selective D2DR and D3DR inhibitor
CAS Number: 71675-85-9
Purity: ≥99%
Molecular Weight: 369.48
Molecular Formula: C17H27N3O4S
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).
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Amisulpride is a selective, potent D2DR and D3DR inhibitor. (Ki values are 2.8 and 3.2 nM respectively for human D2DR and D3DR and > 1000 nM for human D1DR, D4DR and D5DR.) Amisulpride exhibits selectivity for presynaptic dopamine autoreceptors at low doses and blocks postsynaptic D2DR/D3DR at higher doses. Amisulpride interacts with limbic D2-like receptors . Amisulpride is an atypical antipsychotic/antischizophrenic agent with limited extrapyrimidal side effects and a profile distinct from that of haloperidol and remoxipride.


References

Perrault et al (1997) Psychopharmacological profile of amisulpride: an antipsychotic drug with presynaptic D2/D3 dopamine receptor antagonist activity and limbic selectivity. J.Pharmacol.Exp.Ther. 280 73. Schoemaker et al (1997) Neurochemical characterist

Appearance :
Powder
Physical State :
Solid
Solubility :
Soluble in water (partly), dichloromethane, chloroform, DMSO (50 mM), 1eq. HCl (25 mM), methanol, and ethanol (74 mg/ml at 25° C).
Storage :
Store at -20° C
Melting Point :
127° C (lit.)
Boiling Point :
558.91° C at 760 mmHg (Predicted)
Density :
1.20 g/cm3 at 20° C
Refractive Index :
n20D 1.55 (Predicted)
Ki Data :
D2DR: Ki= 2.8 nM (human); D3DR: Ki= 3.2 nM (human)
pK Values :
pKa: 9.37, pKb: 8.97 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
CV2308701
PubChem CID :
Merck Index :
14: 485
MDL Number :
MFCD00866691
EC Number :
275-831-7
SMILES :
CCN1CCCC1CNC(=O)C2=CC(=C(C=C2OC)N)S(=O)(=O)CC

Download SDS (MSDS)

Certificate of Analysis

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Rated 5 out of 5 by from Moller (PubMed ID 14642970) showed that amisulpride Moller (PubMed ID 14642970) showed that amisulpride is an antipsychotic with lower propensity to induce extrapyramidal side effects, as it does not exhibit post synaptic blockade of D2.
Date published: 2015-05-24
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